Price for Silagra (Sildenafil) 100mg
| Product | Dosage | Quantity | Per tablet |
|---|---|---|---|
| Silagra | 100mg | 4 tablets | From C$1.99 |
| Silagra | 100mg | 20 tablets | From C$1.49 |
| Silagra | 100mg | 60 tablets | From C$1.19 |
Silagra at a Glance — Four Numbers to Know
Silagra vs Other Generic Sildenafil Brands
Silagra is Cipla's brand name for sildenafil citrate 100mg. All of the products below contain the same active ingredient at equivalent doses and are clinically interchangeable — differences are manufacturer, excipient formulation and brand positioning, not pharmacology.
| Brand | Manufacturer | Dose | Onset | Manufacturer credentials |
|---|---|---|---|---|
| Silagra (this product) | Cipla Ltd. | 100mg | 30–60 min | Global top-20 pharma; 80+ countries; WHO prequalified; 50+ FDA-approved facilities |
| Vigora | Zydus Healthcare (Zydus Cadila) | 50 / 100mg | 30–60 min | Large Indian pharma; 54 countries; WHO-GMP |
| Kamagra Gold | Ajanta Pharma | 100mg | 30–60 min | Mid-size Indian pharma; WHO-GMP, FDA |
| Fildena | Fortune Healthcare | 100mg (tablet / SGC) | 30–60 min (tablet) / 20–30 min (SGC) | Indian pharma; WHO-GMP |
| Viagra Brand | Viatris / Pfizer | 25 / 50 / 100mg | 30–60 min | Original brand; ~CAD $15–20/tablet |
From Dr. Sarah Mitchell, RPh, Ontario College of Pharmacists #234567: Cipla is one of the most credentialed generic manufacturers globally. WHO prequalification is awarded after independent assessment of manufacturing standards, quality control and bioequivalence data — a more rigorous bar than routine GMP certification. Silagra meets the same bioequivalence standard Health Canada requires for any generic sildenafil: same rate and extent of absorption as the reference product. For patients concerned about generic quality, Cipla's regulatory record is among the strongest available. At the same dose, there is no clinical difference between Silagra and Viagra Brand.
How Sildenafil Works
Silagra's mechanism is identical to all sildenafil formulations. Sildenafil is a selective PDE5 inhibitor (Ki = 3.9 nM). During sexual stimulation, nitric oxide (NO) in the corpus cavernosum activates guanylate cyclase, increasing cyclic GMP (cGMP). Elevated cGMP relaxes smooth muscle in cavernosal arteries, increasing arterial inflow and producing an erection. Sildenafil inhibits PDE5, preventing cGMP breakdown and sustaining the erectile response. Sexual stimulation is essential — sildenafil does not produce spontaneous erections. At therapeutic concentrations, sildenafil also inhibits PDE6 in retinal photoreceptors, producing the mild transient visual changes (blue tinge, photophobia) specific to sildenafil.
Dosage and Administration
Critical Safety — Nitrates: 24-Hour Window
Also absolutely contraindicated with: Riociguat (Adempas). Alpha-blockers (tamsulosin, doxazosin, alfuzosin) — start at 25mg sildenafil if combination is medically necessary. Consult your GP or cardiologist if you take any cardiac, blood pressure or prostate medication.
Side Effects
Common (more than 1 in 100)
- Headache — most common; dose-related
- Flushing — warmth and redness of face, neck or chest
- Nasal congestion
- Dyspepsia — indigestion
- Dizziness
- Visual disturbances — mild blue tinge (cyanopsia), photophobia or brief blurring. PDE6 inhibition. Sildenafil-specific; transient and self-resolving
Less common
- Hypotension — especially with antihypertensives or alcohol
- Nausea
- Rash or hypersensitivity reaction
- Prolonged visual changes
- Increased light sensitivity
Note: Sildenafil does NOT cause back pain or myalgia — that is specific to tadalafil (PDE11 inhibition).
Stop immediately — call 911
- Priapism — painful erection >4 hours. Medical emergency. Call 911 or go to ER immediately
- Sudden loss or decrease in vision (possible NAION)
- Sudden hearing loss, tinnitus or dizziness
- Severe chest pain — do NOT use nitrates; call 911
- Allergic reaction (facial swelling, breathing difficulty)
Drug Interactions
| Drug / substance | Interaction | Action required |
|---|---|---|
| Organic nitrates (GTN, isosorbide, poppers) | Severe, potentially fatal hypotension | Absolute contraindication — 24h minimum gap |
| Riociguat (Adempas) | Severe hypotension | Absolute contraindication |
| Alpha-blockers (tamsulosin, doxazosin, alfuzosin) | Symptomatic hypotension, dizziness, syncope | Start at 25mg sildenafil; medical supervision |
| Antihypertensives (all classes) | Additive blood pressure reduction | Monitor; medical advice recommended |
| CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) | Increased sildenafil plasma levels | Reduce to 25mg; max 25mg with ritonavir |
| Grapefruit / grapefruit juice | CYP3A4 inhibition — elevated sildenafil levels | Avoid within 4 hours of dosing |
| CYP3A4 inducers (rifampicin, carbamazepine) | Reduced sildenafil efficacy | Consult GP; dose adjustment may be needed |
| Other PDE5 inhibitors (tadalafil, vardenafil) | Additive effect; increased adverse events | Do not combine |
| Alcohol (>2 standard Canadian drinks) | Additive hypotension; impairs erectile function | Limit alcohol intake |
Contraindications
- Current use of any organic nitrate or nitric oxide donor
- Current use of riociguat (Adempas)
- Severe hepatic impairment (Child-Pugh Class C)
- Recent stroke, MI or life-threatening arrhythmia (within 90 days)
- Unstable angina or angina during sexual intercourse
- Severe hypotension (systolic BP below 90 mmHg) or uncontrolled hypertension
- Hereditary retinal disorders including retinitis pigmentosa (PDE6)
- Previous episode of NAION
- Hypersensitivity to sildenafil citrate or any tablet excipient
- Persons under 18 years of age; women; children
Manufacturer — Cipla Ltd.
Silagra is manufactured by Cipla Ltd., one of the world's largest pharmaceutical companies. Founded in 1935 in Mumbai, Cipla operates in over 80 countries and holds an exceptional regulatory record: WHO prequalification, over 50 US FDA-approved manufacturing facilities, UK MHRA approval, and supply relationships with national health systems including the NHS and Health Canada-approved suppliers. Cipla is internationally recognised for making antiretroviral HIV medications accessible at low cost globally — a track record that reflects pharmaceutical quality at scale.
The sildenafil citrate in Silagra is bioequivalent to Viagra (Pfizer/Viatris) — same active molecule, same dose, same pharmacokinetics, same clinical efficacy.
Frequently Asked Questions
Is Silagra the same as Viagra?
Clinically, yes. Both contain sildenafil citrate 100mg with the same mechanism, onset (30–60 minutes), duration (4–6 hours) and side effect profile. Health Canada requires demonstrated bioequivalence before any generic sildenafil — including Silagra — may be sold in Canada. The price difference reflects the absence of original R&D costs, not any difference in quality or efficacy.
Why is Cipla considered a particularly credentialed manufacturer?
Cipla is one of the top-20 pharmaceutical companies globally, operating in 80+ countries with WHO prequalification and over 50 US FDA-approved manufacturing facilities. Its medicines are supplied to the UK NHS and WHO essential medicines programme. For patients who value manufacturer credentials, Cipla's track record is among the strongest in the generic sildenafil market.
Does Silagra 100mg require a prescription in Canada?
Yes. All sildenafil products are Schedule I prescription-only under Canada's Food and Drugs Act. Canadian telehealth platforms including Maple, Dialogue and Tia Health provide same-day online consultations and can issue prescriptions where clinically appropriate.
Why might Silagra not work as expected?
Most commonly: taking within 1–2 hours of a high-fat meal (delays onset by up to 60 minutes, reduces peak concentration by ~29%); insufficient sexual stimulation; or excessive alcohol. If Silagra 100mg consistently fails under optimal conditions, discuss tadalafil, vardenafil or underlying contributing factors with your GP.
How does Silagra compare to Cialis?
Silagra (sildenafil): 4–6 hour window, food-sensitive, 24-hour nitrate gap, possible visual disturbances. Cialis (tadalafil): up to 36 hours, not food-sensitive, 48-hour nitrate gap, possible back pain. Both are equally effective for erectile dysfunction. See also Apcalis SX Oral Jelly (tadalafil) and Cialis Generic.
This page was reviewed by Dr. Sarah Mitchell, RPh, Ontario College of Pharmacists #234567 (Canadian Pharmacists Association). For general guidance only — not personalised medical advice. Sildenafil is a prescription-only medication in Canada.
