Price for Tadapox (Tadalafil/Dapoxetine)
| Product | Composition | Quantity | Per tablet |
|---|---|---|---|
| Tadapox | Tadalafil 20mg + Dapoxetine 60mg | 10 tablets | From C$3.49 |
| Tadapox | Tadalafil 20mg + Dapoxetine 60mg | 30 tablets | From C$2.99 |
Tadapox at a Glance — Four Numbers to Know
How Tadapox Works — Two Mechanisms in One Tablet
Tadapox works through two distinct and independent pharmacological mechanisms — one for each active ingredient. Understanding both is essential for safe and effective use.
Tadapox vs Taking Tadalafil and Dapoxetine Separately
| Parameter | Tadapox (combination tablet) | Separate tablets |
|---|---|---|
| Convenience | One tablet — simpler | Two separate tablets |
| Dose flexibility | Fixed 20mg/60mg — cannot adjust individually | Each dose adjusted independently by physician |
| Suitability | Only appropriate when both ED and PE are present | Each medication used only where clinically needed |
| Side effect attribution | Difficult to identify which component causes which effect | Clear attribution; easier to manage |
| Cost | Typically lower than buying both separately | Higher combined cost |
From Dr. Sarah Mitchell, RPh, Ontario College of Pharmacists #234567: Tadapox is only clinically appropriate for men who have both erectile dysfunction and premature ejaculation simultaneously. For men with ED only, a tadalafil product (Tadacip, Apcalis SX) is sufficient. For men with PE only, dapoxetine alone is more appropriate. The fixed-dose combination removes the ability to titrate each component independently — this is relevant because dapoxetine at 60mg may produce more nausea and dizziness than a lower starting dose would in some men. Before using Tadapox, a physician should confirm that both conditions are present and that there are no interactions with current medications — particularly any serotonergic drugs, which constitute an absolute contraindication to the dapoxetine component.
Dosage and Administration
- Swallow one tablet whole with a full glass of water — do not crush, chew or break
- Take 1–3 hours before anticipated sexual activity; tadalafil reaches full effect in 30–120 minutes, dapoxetine Tmax is approximately 1–2 hours
- Do not exceed one tablet in any 24-hour period
- May be taken with or without food — tadalafil is not significantly affected by food; a high-fat meal may slightly delay dapoxetine absorption but does not significantly alter efficacy
- Limit alcohol to no more than 1 standard Canadian drink — alcohol increases the risk of orthostatic hypotension and dizziness with dapoxetine, and additive hypotension with tadalafil; the combination is more sensitive to alcohol than either drug alone
- Do not take within 24 hours of any nitrate medication (tadalafil component requires 48 hours)
- Do not take within 14 days of stopping any MAO inhibitor — risk of serotonin syndrome
- A valid prescription from a licensed Canadian physician is required for both components
Critical Safety — Nitrates (48h) and MAO Inhibitors (Absolute)
MAO inhibitor safety window: Do not take Tadapox within 14 days of stopping any irreversible MAO inhibitor (phenelzine, tranylcypromine). For reversible MAOIs (moclobemide), wait at least 24 hours. Do not start any MAO inhibitor within 7 days of stopping dapoxetine. Serotonin syndrome can be rapid, severe and life-threatening — symptoms include agitation, confusion, rapid heart rate, high fever, muscle rigidity and seizures. If suspected, call 911 immediately.
Side Effects
Common (from both components)
- Headache — very common; both components contribute
- Nausea — primarily dapoxetine; more frequent than with tadalafil alone
- Dizziness — both components; important: dapoxetine adds orthostatic dizziness risk, especially in first hour
- Flushing — primarily tadalafil
- Nasal congestion — tadalafil
- Back pain and myalgia — tadalafil-specific (PDE11 inhibition)
- Diarrhoea — dapoxetine
- Somnolence (sleepiness) — dapoxetine SSRI effect
Note: Tadalafil does NOT cause visual disturbances (no PDE6 inhibition). Dapoxetine does NOT cause erection-related effects.
Less common
- Orthostatic hypotension — dapoxetine; risk of fainting on standing, especially in first 3 hours
- Insomnia — dapoxetine SSRI effect
- Anxiety or irritability — dapoxetine
- Dry mouth — dapoxetine
- Peripheral oedema — tadalafil
- Hyperhidrosis (sweating) — dapoxetine
Important — alcohol: Even 1–2 standard drinks significantly increases dizziness and fainting risk with dapoxetine. Alcohol is more hazardous with this combination than with tadalafil alone.
Stop immediately — call 911
- Priapism — painful erection lasting more than 4 hours. Medical emergency
- Serotonin syndrome — agitation, confusion, rapid heart rate, fever, muscle rigidity, seizures. Potentially fatal. Call 911
- Syncope (fainting) — especially with alcohol or on standing
- Sudden vision or hearing loss (tadalafil component)
- Severe chest pain — do NOT use nitrates; call 911
Drug Interactions — Expanded List (Both Components)
| Drug / substance | Component | Interaction | Action required |
|---|---|---|---|
| MAO inhibitors (phenelzine, tranylcypromine, selegiline, moclobemide, linezolid) | Dapoxetine | Serotonin syndrome — potentially fatal | Absolute contraindication — 14-day washout from irreversible MAOI |
| Organic nitrates (GTN, isosorbide, poppers) | Tadalafil | Severe, potentially fatal hypotension | Absolute contraindication — 48h minimum gap |
| Riociguat (Adempas) | Tadalafil | Severe hypotension | Absolute contraindication |
| Other SSRIs/SNRIs (fluoxetine, sertraline, paroxetine, venlafaxine, duloxetine) | Dapoxetine | Serotonin syndrome risk; increased dapoxetine levels with CYP2D6 inhibitors | Contraindicated — do not combine |
| Tramadol | Dapoxetine | Serotonin syndrome risk | Contraindicated — do not combine |
| Triptans (sumatriptan, rizatriptan) | Dapoxetine | Serotonin syndrome risk | Contraindicated — do not combine |
| Alpha-blockers (tamsulosin, doxazosin) | Tadalafil | Symptomatic hypotension | Medical supervision required |
| Antihypertensives (all classes) | Tadalafil | Additive blood pressure reduction | Monitor; medical advice recommended |
| CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) | Both | Increased plasma levels of both components | Contraindicated with potent inhibitors; reduce doses with moderate inhibitors under physician guidance |
| Alcohol | Dapoxetine + Tadalafil | Additive hypotension and dizziness; significant orthostatic syncope risk | Limit to maximum 1 standard drink; ideally avoid |
| Other PDE5 inhibitors (sildenafil, vardenafil) | Tadalafil | Additive effect; increased adverse events | Do not combine |
Contraindications
- Current use of any MAO inhibitor, or within 14 days of stopping an irreversible MAOI
- Current use of any other SSRI or SNRI antidepressant
- Current use of tramadol, triptans or thioridazine
- Current use of any organic nitrate or nitric oxide donor
- Current use of riociguat (Adempas)
- Significant heart disease — heart failure, unstable angina, cardiac arrhythmia, recent MI or stroke (within 90 days)
- Severe hepatic impairment (Child-Pugh Class C) — both components hepatically metabolised
- Severe renal impairment (CrCl below 30 mL/min)
- Moderate to severe bipolar disorder — dapoxetine may precipitate mania
- History of syncope (fainting spells) — dapoxetine increases orthostatic hypotension risk
- Severe or uncontrolled hypertension or hypotension
- Hereditary retinal disorders including retinitis pigmentosa
- Hypersensitivity to tadalafil, dapoxetine or any tablet excipient
- Persons under 18 years of age; women; children
Manufacturer
Tadapox is manufactured by Sunrise Remedies Pvt. Ltd., an Indian pharmaceutical company holding WHO Good Manufacturing Practice (GMP) certification. Sunrise Remedies produces a range of combination sexual health tablets and supplies to regulated generic markets internationally. The tadalafil and dapoxetine in Tadapox are pharmaceutical grade active ingredients meeting the same quality standards as standalone tadalafil and dapoxetine products.
Frequently Asked Questions
What is Tadapox used for?
Tadapox is a combination tablet for men who experience both erectile dysfunction and premature ejaculation simultaneously. The tadalafil 20mg component addresses erectile dysfunction through PDE5 inhibition, providing up to 36 hours of potential erectile response to sexual stimulation. The dapoxetine 60mg component addresses premature ejaculation through short-acting SSRI activity, delaying the ejaculatory threshold. It is not appropriate for men with only one of these conditions — a single-component medication is preferable in that case.
How is dapoxetine different from other antidepressants?
Dapoxetine is an SSRI (the same drug class as fluoxetine, sertraline and paroxetine), but it is specifically developed for on-demand use rather than daily dosing. Its key pharmacokinetic difference is its rapid onset (Tmax ~1–2 hours) and very short half-life (~1–2 hours), unlike conventional antidepressant SSRIs which have half-lives of days to weeks. This makes dapoxetine suitable for use before specific sexual encounters rather than as a continuous daily treatment. However, it retains all the drug interaction risks of the SSRI class, including serotonin syndrome with MAO inhibitors.
Is Tadapox safe to use with alcohol?
No — alcohol is significantly more hazardous with Tadapox than with tadalafil alone. Dapoxetine increases the risk of orthostatic hypotension (fainting on standing) and dizziness, and alcohol amplifies both effects. Even 1–2 standard drinks can produce symptomatic dizziness or syncope in susceptible individuals. Alcohol consumption should be minimised or avoided on the day Tadapox is taken. This is a stricter recommendation than for tadalafil-only products.
Can I take Tadapox if I am on antidepressants?
No. If you take any SSRI (fluoxetine, sertraline, paroxetine, citalopram, escitalopram), SNRI (venlafaxine, duloxetine), tricyclic antidepressant, or any MAO inhibitor, Tadapox is contraindicated due to the dapoxetine component — risk of serotonin syndrome. This is an absolute contraindication. You must consult your prescribing physician before using any medication containing dapoxetine.
Does Tadapox require a prescription in Canada?
Yes. Both tadalafil and dapoxetine are prescription-only in Canada. A valid prescription is required. Given the expanded drug interaction profile of the combination — particularly the serotonergic contraindications — physician assessment before use is particularly important. Telehealth platforms including Maple, Dialogue and Tia Health provide online consultations where clinically appropriate.
This product page was reviewed by Dr. Sarah Mitchell, RPh, Ontario College of Pharmacists #234567 (Canadian Pharmacists Association). Information is for general guidance only and does not constitute personalised medical advice. Both tadalafil and dapoxetine are prescription-only medications in Canada — consult your physician or pharmacist before use. The expanded drug interaction profile of this combination requires physician assessment before initiating treatment.
