Loading...



Shopping cart processing ...
0
Your cart0
Products 0
Price $0.00
Bestsellers Pill categories
Customer Support 24/7
usa canada USA
uk UK
au AU
Live Chat 24/7
Menu
Customer Support 24/7
USA/Canada Toll Free USA
UK UK
AUS AU
Customer Support 24/7
usacanada USA
uk UK
au AU
We accept
  • Visa
  • MasterCard
  • Amex
  • JCB
Currency
USD
Your cart: $0.00 (0 items)
Checkout

Categories list

Choosing us you get:

  • Reliable supplier
  • Low Internet prices
  • Free bonus pills
  • Discount on all future orders
  • Discreet package
  • SSL secure orders
Worldwide Shipping!

Testimonials:

  • Kenny Klunder Chicago, IL, USA
    I am loyal to this shop for more than 3 years. My life time discount makes already 15% and my friends might use it as well. Thank you for accumulation discounts.
More info »

Zyprexa

Zyprexa
Zyprexa is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children who are at least 13 years old.

Brand: Olanzapine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
View product image
Package Price Per pill Save Order
Zyprexa 20 mg
120 pills - 20 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$273.93 $2.28 $174.03 Add to cart
90 pills - 20 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$217.75 $2.42 $118.22 Add to cart
60 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$165.95 $2.77 $58.03 Add to cart
30 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$111.99 $3.73 No Add to cart
Zyprexa 15 mg
180 pills - 15 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$359.95 $2.00 $86.03 Add to cart
120 pills - 15 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$251.51 $2.10 $45.81 Add to cart
90 pills - 15 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$198.09 $2.20 $24.90 Add to cart
60 pills - 15 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$139.01 $2.32 $9.65 Add to cart
30 pills - 15 mg $74.33 $2.48 No Add to cart
Zyprexa 10 mg
270 pills - 10 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$445.95 $1.65 $271.80 Add to cart
180 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$299.99 $1.67 $178.51 Add to cart
120 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$229.93 $1.92 $89.07 Add to cart
90 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$185.75 $2.06 $53.50 Add to cart
60 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$135.99 $2.27 $23.51 Add to cart
30 pills - 10 mg $79.75 $2.66 No Add to cart
Zyprexa 7.5 mg
360 pills - 7.5 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$409.99 $1.14 $321.89 Add to cart
270 pills - 7.5 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$321.77 $1.19 $227.14 Add to cart
180 pills - 7.5 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$222.99 $1.24 $142.95 Add to cart
120 pills - 7.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$163.99 $1.37 $79.97 Add to cart
90 pills - 7.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$131.95 $1.47 $51.02 Add to cart
60 pills - 7.5 mg $98.91 $1.65 $23.07 Add to cart
30 pills - 7.5 mg $60.99 $2.03 No Add to cart
Zyprexa 5 mg
360 pills - 5 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$239.99 $0.67 $167.89 Add to cart
270 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$189.95 $0.70 $115.96 Add to cart
180 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$131.99 $0.73 $71.95 Add to cart
120 pills - 5 mg $95.93 $0.80 $40.03 Add to cart
90 pills - 5 mg $77.85 $0.87 $24.12 Add to cart
60 pills - 5 mg $56.74 $0.95 $11.24 Add to cart
30 pills - 5 mg $33.99 $1.13 No Add to cart
Zyprexa 2.5 mg
360 pills - 2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$121.99 $0.34 $105.89 Add to cart
270 pills - 2.5 mg $93.99 $0.35 $76.92 Add to cart
180 pills - 2.5 mg $68.99 $0.38 $44.95 Add to cart
120 pills - 2.5 mg $51.99 $0.43 $23.97 Add to cart
90 pills - 2.5 mg $43.73 $0.49 $13.24 Add to cart
60 pills - 2.5 mg $34.99 $0.58 $2.99 Add to cart
30 pills - 2.5 mg $18.99 $0.63 No Add to cart

Product description

Drug Name

Zyprexa (Olanzapine)

Pharmacological action

Antipsychotic medicine (neuroleptic). It has affinity for serotonin 5-NT2A/C-, 5-NT3-, 5-NT6-receptors; dopamine D1-, D2-, D3-, D4-, D5-receptors; M1-5-cholinoreceptors; α1-adrenoreceptors and histamine H1-receptors. It shows antagonism to serotonin 5-NT-, dopamine and choline receptors.


Under in vitro and in vivo conditions it has a more pronounced affinity and activity towards serotonin 5-HT2-receptors compared to dopamine D2-receptors. According to electrophysiological studies, olanzapine selectively decreases excitability of mesolimbic (A10) dopaminergic neurons and, at the same time, has little effect on striatal (A9) nerve pathways involved in motor function regulation. Olanzapine reduces the conditioned protective reflex (the test that characterizes antipsychotic activity) at lower doses than are required to achieve catalepsy (a disorder reflecting a side effect on motor function). Unlike other neuroleptics, olanzapine enhances the antianxiety effects of the anxiolytic test.


The use of olanzapine reduces both productive (including delirium, hallucinations) and negative disturbances.


Pharmacokinetics 

After oral administration, olanzapine is well absorbed from the gastrointestinal tract, Cmax in plasma is reached after 5-8 hours. Plasma concentrations of olanzapine are linearly dose-dependent (range 1 to 20 mg). Food intake has no effect on the absorption of olanzapine.


At plasma concentrations of 7 to 1000 ng/ml, binding to plasma proteins is about 93%.


Olanzapine is metabolized in the liver by conjugation and oxidation. The major circulating metabolite is 10-N-glucuronide, which theoretically does not penetrate the BBB. CYP1A2 and CYP2D6 isoenzymes are involved in the formation of N-desmethyl and 2-hydroxymethyl metabolites of olanzapine. Experimental animal studies have shown that these metabolites have significantly less pronounced pharmacological activity in vivo than olanzapine. The main pharmacological activity is due to unchanged olanzapine.


The activity of CYP2D6 isoenzyme does not affect the metabolism of olanzapine.


In healthy volunteers after oral administration, the T1/2 of olanzapine is 33 h (21-54 h) and average plasma clearance is 26 l/h (12-47 l/h).


About 57% of radioisotope-labeled olanzapine is excreted in the urine, mainly as metabolites.

Contraindications for use

Hypersensitivity to olanzapine.

Use in pregnancy and lactation

Adequate and strictly controlled clinical safety studies of olanzapine use in pregnancy have not been conducted. Use is possible only in cases when the expected benefit of therapy for the mother significantly exceeds the potential risk for the fetus.


There are currently no data on excretion of olanzapine in breast milk. Breast-feeding should be discontinued if it is necessary to use during lactation.


Use in liver dysfunction

In moderate hepatic impairment, the initial dose is 5 mg/day.

Administration in renal impairment

In severe renal insufficiency, the initial dose is 5 mg/day.

Administration in children

Safety and effectiveness of olanzapine in patients under 18 years of age has not been studied.

Use in elderly patients

For elderly patients, the starting dose is 5 mg/day.

Indications of active substances of Zyprexa

Treatment of exacerbations, maintenance and long-term antiretroviral therapy of schizophrenia and other psychotic disorders with significant productive (including delirium, hallucinations, automatisms) and/or negative (including emotional flatness, decreased social activity, impaired speech) symptoms, and concomitant affective disorders.


Treatment of acute manic or mixed seizures in bipolar affective disorder with/without psychotic manifestations and with/without rapid phase change.


Dosing regimen

The initial dose is 10-15 mg/day. The daily dose should be adjusted individually depending on the clinical condition of the patient. Therapeutic doses are 5-20 mg/day. Increasing the dose beyond the standard one (10-15 mg/day, depending on indications) is recommended only after an appropriate clinical examination of the patient. The dose should be increased gradually, at intervals of at least 24 hours.


In elderly patients and in patients with severe renal insufficiency or moderate hepatic insufficiency, the initial dose is 5 mg/day.


A reduction in the starting dose is recommended for patients with a combination of factors (female patients, elderly, nonsmokers) in which olanzapine metabolism may be delayed.