Zyloprim

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: March 2024
Package | Price | Per pill | Save | Order |
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Zyloprim 300 mg | ||||
360 pills - 300 mg
+ 4 free Viagra 100 mg, 3% discount for future orders |
$159.99 | $0.44 | $163.89 | Add to cart |
270 pills - 300 mg
+ 4 free Viagra 100 mg, 3% discount for future orders |
$123.93 | $0.46 | $118.98 | Add to cart |
180 pills - 300 mg | $89.93 | $0.50 | $72.01 | Add to cart |
120 pills - 300 mg | $67.91 | $0.57 | $40.05 | Add to cart |
90 pills - 300 mg | $56.99 | $0.63 | $23.98 | Add to cart |
60 pills - 300 mg | $45.95 | $0.77 | $8.03 | Add to cart |
30 pills - 300 mg | $26.99 | $0.90 | No | Add to cart |
Zyloprim 100 mg | ||||
360 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders |
$119.93 | $0.33 | $95.47 | Add to cart |
270 pills - 100 mg | $93.87 | $0.35 | $67.68 | Add to cart |
180 pills - 100 mg | $67.96 | $0.38 | $39.74 | Add to cart |
120 pills - 100 mg | $51.95 | $0.43 | $19.85 | Add to cart |
90 pills - 100 mg | $41.99 | $0.47 | $11.86 | Add to cart |
60 pills - 100 mg | $33.53 | $0.56 | $2.37 | Add to cart |
30 pills - 100 mg | $17.95 | $0.60 | No | Add to cart |
Product description
Drug title
Zyloprim (Allopurinol)
Pharmacological action
A remedy which interferes with the synthesis of uric acid. It is a structural analog of hypoxanthine. It inhibits xanthine oxidase enzyme, which is involved in conversion of hypoxanthine into xanthine and xanthine into uric acid. This is due to a decrease in the concentration of uric acid and its salts in the liquid media of the body and urine, which helps to dissolve existing urate deposits and prevents their formation in the tissues and kidneys. Zyloprim (Allopurinol) administration increases urinary excretion of hypoxanthine and xanthine.
Pharmacokinetics
After oral administration is almost completely (90%) absorbed from the gastrointestinal tract. It is metabolized to form alloxanthine, which retains the ability to inhibit xanthine oxidase for quite a long time. Cmax of allopurinol in blood plasma is reached on average in 1.5 hours, alloxanthin - in 4.5 hours after a single dose.
T1/2 of allopurinol is 1-2 hours, of alloxantine about 15 hours. About 20% of the dose taken is excreted through the intestine, the rest through the kidneys.
Contraindications for use
Severe liver and/or renal dysfunction, pregnancy, lactation, hypersensitivity to allopurinol.
Administration during pregnancy and lactation
It is contraindicated for use during pregnancy and lactation (breast-feeding).
Administration in patients with liver dysfunction
Contraindication: Severe hepatic impairment. Allopurinol should be used with caution in patients with liver dysfunction (dose reduction is required).
Administration in impaired renal function
Contraindication: severe renal dysfunction. Allopurinol should be used with caution in patients with impaired renal function (dose reduction is required).
Administration in children
It is used in children only in malignant tumors (especially leukemia), as well as in some enzyme disorders (Lesch-Nichen syndrome).
Regimen of dosage is adjusted individually, under control of concentration of urate and uric acid in blood and urine: for children under 15 years old it is 10-20 mg/kg/day or 100-400 mg/day.
Zyloprim (Allopurinol) active substance indications
Treatment and prevention of gout and hyperuricaemia of various genesis (including in combination with nephrolithiasis, renal failure, urate nephropathy). Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricosuria. Increased formation of urate due to enzyme disorders. Prevention of acute nephropathy in cytostatic and radiation therapy for tumors and leukemia, as well as in complete therapeutic fasting.
Dosing regimen
It is established individually, under control of urate and uric acid concentration in blood and urine. Adults when taken orally - 100-900 mg/day, depending on the severity of the disease. Frequency of intake is 2-4 times per day after meals. In children under 15 years of age 10-20 mg/kg/day or 100-400 mg/day.
Maximal doses: In patients with kidney dysfunction (including those caused by urate nephropathy) the dose is 100 mg/day. The dose may be increased in cases when against the background of the current therapy there are still high concentrations of urate in blood and urine.