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Zithromax

Zithromax
Zithromax is used for the treatment of light and moderate infection caused by some bacteria. It can be used separately or in combination with other drugs for the treatment and prevention of some infections at the patients having AIDS terminal stage.

Brand: Azithromycin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: March 2024
Package Price Per pill Save Order
Zithromax 500 mg
270 pills - 500 mg
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$313.25 $1.16 $379.30 Add to cart
180 pills - 500 mg
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120 pills - 500 mg
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$165.23 $1.38 $142.57 Add to cart
90 pills - 500 mg
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$136.03 $1.51 $94.82 Add to cart
60 pills - 500 mg
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$106.33 $1.77 $47.57 Add to cart
30 pills - 500 mg $76.95 $2.57 No Add to cart
Zithromax 250 mg
270 pills - 250 mg
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$170.55 $0.63 $261.36 Add to cart
180 pills - 250 mg
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$133.95 $0.74 $153.99 Add to cart
120 pills - 250 mg $98.01 $0.82 $93.95 Add to cart
90 pills - 250 mg $83.99 $0.93 $59.98 Add to cart
60 pills - 250 mg $69.95 $1.17 $26.03 Add to cart
30 pills - 250 mg $47.99 $1.60 No Add to cart
Zithromax 100 mg
270 pills - 100 mg
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$123.55 $0.46 $87.73 Add to cart
180 pills - 100 mg $89.93 $0.50 $50.92 Add to cart
120 pills - 100 mg $67.75 $0.56 $26.15 Add to cart
90 pills - 100 mg $57.79 $0.64 $12.64 Add to cart
60 pills - 100 mg $46.95 $0.78 No Add to cart

Product description

Drug title

Zithromax (Azithromycin)

Pharmacological action

It is a broad-spectrum bacteriostatic agent of macrolide-azalid group. Binding to 50S subunit of ribosomes, it inhibits peptide translocation stage, inhibits protein synthesis, inhibits bacterial growth and reproduction, in high concentrations it has bactericidal effect. Acts on extra- and intracellularly located pathogens.


Microorganisms may be initially resistant to the antibiotic or may acquire resistance to it.


Pharmacokinetics

After oral administration azithromycin is well absorbed and rapidly distributed in the body. Bioavailability after a single use of 0.5 g is 37% (effect of "first passage" through liver), Cmax after peroral use of 0.5 g is 0.4 mg/l, time to reach maximum concentration (TCmax) is 2-3 hours.


Concentration in tissues and cells is 10-50 times higher than in blood serum. Vd is 31.1 l/kg, the binding to plasma proteins is inversely proportional to the concentration in blood and leaves 7-50%.


Azithromycin is acid resistant and lipophilic. It easily passes through histohematic barriers and penetrates well into respiratory tract, urogenital organs and tissues including prostate, skin and soft tissues. It is also transported to the site of infection by phagocytes (polymorphonuclear leukocytes and macrophages), where it is released in the presence of bacteria. It penetrates through cell membranes and creates high concentrations in cells, which is especially important for eradication of intracellularly located pathogens. In the foci of infection the concentrations are 24-34% higher than in healthy tissues and correlate with the severity of the inflammatory process. It remains in effective concentrations for 5-7 days after the last dose.


It is demethylated in the liver, the resulting metabolites are inactive. CYP3A4, CYP3A5, CYP3A7 isoenzymes are involved in azithromycin metabolism, of which it is an inhibitor. Plasma clearance is 630 ml/min: T1/2 between 8 and 24 hours after intake is 14-20 hours, T1/2 between 24 and 72 hours is 41 hours.


More than 50% of azithromycin is excreted unchanged in the intestine, 6% - by the kidneys. Food intake significantly changes pharmacokinetics Cmax increases (by 31%), AUC does not change.


In elderly men (65-85 years old) pharmacokinetic parameters do not change, in women Cmax increases (by 30-50%).


Contraindications to use

  • severe hepatic and/or renal insufficiency;
  • children under 12 years of age with body weight less than 45 kg (for this dosage form);
  • breastfeeding;
  • concomitant use with ergotamine and dihydroergotamine;
  • Hypersensitivity to antibiotics of the macrolide group.

With caution


  • Moderate hepatic and renal dysfunction;
  • In arrhythmias or predisposition to arrhythmias and QT interval prolongation;
  • co-administration of terfenadine, warfarin, digoxin.

Administration during pregnancy and lactation

It is recommended to use azithromycin during pregnancy only in cases when the expected benefit to the mother exceeds the potential risk to the fetus.


Breast-feeding should be suspended during treatment with azithromycin.


Use in patients with liver dysfunction

It is contraindicated in severe hepatic insufficiency. Use with caution in mild hepatic impairment.

Administration in impaired renal function

Contraindicated in patients with severe renal insufficiency.


For patients with moderate renal impairment (CKD > 40 ml/min), no adjustment is required.


Administration in children

Contraindication for this dosage form - children under 12 years of age with body weight less than 45 kg.

Administration in elderly patients

Administration in adults (including elderly people)

Indications of the drug Azithromycin

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:


  • Infections of the upper respiratory tract and ENT organs: pharyngitis, tonsillitis, sinusitis, otitis media;
  • lower respiratory tract infections: acute bronchitis, exacerbation of chronic bronchitis, pneumonia, including those caused by atypical pathogens;
  • skin and soft tissue infections: moderately severe common acne, rye, impetigo, secondary infected dermatoses;
  • initial stage of Lyme disease (borreliosis) - erythema migrans;
  • Genitourinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis).

Dosing regimen

Azithromycin is taken orally once daily 500 mg, regardless of meals.


Adults (including elderly) and children over 12 years of age with body weight over 45 kg


In infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues: 500 mg 1 time per day for 3 days (course dose - 1.5 g).


With common acne of moderate severity: 2 caps. 250 mg once a day for 3 days, then 250 mg twice a week for 9 days. The course dose is 6.0 g.


In erythema migrans: on the first day simultaneously 2 capsules of 500 mg, then from day 2 to day 5 500 mg daily. The course dose is 3.0 g.


In urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis): 2 capsules 500 mg at a time.


Administration to patients with impaired renal function: for patients with moderate renal impairment (CKD > 40 ml/min) no correction is required.