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Zebeta

Zebeta
Zebeta is used to treat patients with high blood pressure patients. It can be used alone or with other drugs.

Brand: Bisoprolol

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
Package Price Per pill Save Order
Zebeta 10 mg
360 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$135.99 $0.38 $175.89 Add to cart
270 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$104.55 $0.39 $129.36 Add to cart
180 pills - 10 mg $74.99 $0.42 $80.95 Add to cart
120 pills - 10 mg $57.99 $0.48 $45.97 Add to cart
90 pills - 10 mg $47.93 $0.53 $30.04 Add to cart
60 pills - 10 mg $37.95 $0.63 $14.03 Add to cart
30 pills - 10 mg $25.99 $0.87 No Add to cart
Zebeta 5 mg
270 pills - 5 mg $89.95 $0.33 $107.60 Add to cart
180 pills - 5 mg $65.93 $0.37 $65.77 Add to cart
120 pills - 5 mg $49.91 $0.42 $37.89 Add to cart
90 pills - 5 mg $42.95 $0.48 $22.90 Add to cart
60 pills - 5 mg $34.99 $0.58 $8.91 Add to cart
30 pills - 5 mg $21.95 $0.73 No Add to cart
Zebeta 2.5 mg
270 pills - 2.5 mg $85.95 $0.32 $61.43 Add to cart
180 pills - 2.5 mg $63.51 $0.35 $34.74 Add to cart
120 pills - 2.5 mg $47.85 $0.40 $17.65 Add to cart
90 pills - 2.5 mg $40.23 $0.45 $8.90 Add to cart
60 pills - 2.5 mg $32.75 $0.55 No Add to cart

Product description

Drug Title

Zebeta (Bisoprolol)

Pharmacological action

A selective beta1-adrenoblocker without intrinsic sympathomimetic activity; it has no membrane-stabilizing activity. Reduces plasma renin activity, decreases myocardial oxygen demand, decreases HR (at rest and during exercise) and cardiac output, without significantly decreasing stroke volume. Inhibits AV conduction. It has antianginal and hypotensive effects. In high doses (200 mg or more) it may also cause blockade of β2-adrenoreceptors mainly in bronchi and in vascular smooth muscle.


The hypotensive effect is associated with a decrease in the minute blood volume, sympathetic stimulation of peripheral vessels, reduction of renin-angiotensin system activity (of greater importance in patients with initial renin hypersecretion), restoration of sensitivity in response to BP reduction and influence on CNS.


Antianginal effect is due to a decrease in myocardial oxygen demand as a result of HR shortening and reduction of contractility, prolongation of diastole, improvement of myocardial perfusion.


Antiarrhythmic effect is caused by the removal of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased content of CAMF, arterial hypertension), reduction of spontaneous excitation rate of sinus and ectopic pacemakers and AV conduction slowing down (mainly in antegrade and, to a lesser extent, in retrograde direction through the AV node) and along complementary pathways.


Pharmacokinetics

Absorption is 80-90%; absorption is not affected by food intake.


Cmax in plasma is reached after 2-4 hours. Binding to plasma proteins is 26-33%. Bisoprololol crosses the BBB and placental barrier to a small extent; it is excreted with breast milk.


It is metabolized in the liver.


T1/2 is 9-12 hours. Excreted by the kidneys - 50% unchanged, less than 2% in bile.

Contraindications to use

Acute heart failure, chronic heart failure in the decompensation stage, cardiogenic shock, collapse, AV-blockade of degree II and III (without pacemaker), SSRI, sinoatrial block, severe bradycardia (heart rate <50 bpm), Prinzmetal angina, severe decrease of BP (systolic BP <90 mm Hg). ), severe bronchial asthma and history of COPD, advanced peripheral circulatory disorders, Raynaud's disease, pheochromocytoma (without concomitant use of alpha-adrenoblockers), metabolic acidosis, concomitant use of MAO inhibitors (except type B MAO inhibitors), children and adolescents under 18 years of age, hypersensitivity to bisoprolol and other beta-adrenoblockers.


Administration during pregnancy and lactation

Its use during pregnancy and lactation is not recommended and is possible when the expected benefits to the mother exceed the potential risk of side effects for the fetus and child.


In exceptional cases of use in pregnancy, bisoprolol should be withdrawn 72 hours before the expected delivery date due to the possibility of bradycardia, arterial hypotension, hypoglycemia and respiratory depression in the newborn. If cancellation is not possible, the neonate should be closely monitored for 72 h after delivery.


If it is necessary to use bisoprolol during lactation, breastfeeding should be discontinued.


Use in liver dysfunction

The dosage of 10 mg/day should not be exceeded in severe hepatic impairment.

Administration in impaired renal function

Do not exceed the dose of 10 mg/day in renal failure (CKR less than 20 ml/min).


Administration in children

It is not recommended to use in children.

Indications of active substances of the drug Zebeta (Bisoprolol)

Arterial hypertension, prevention of angina attacks, chronic heart failure.

Dosing regimen

 The optimal dosing regimen is determined by the doctor. Should be strictly in accordance with the drug used dosage form of a particular drug indications for use and the dosing regimen.

Individual. For oral administration the daily dose is 2.5-10 mg and the frequency of administration is 1 time per day. The maximum daily dose is 10 mg.