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Zanaflex

Zanaflex
Zanaflex is a muscle relaxant used to help to relax certain muscles of your body. It eases the spasms and increased muscular tonus caused by medical problems such as multiple sclerosis or spinal cord injury. This drug is sometimes given for other purposes; ask your doctor or pharmacist for more information.

Brand: Tizanidine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
Package Price Per pill Save Order
Zanaflex 4 mg
270 pills - 4 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$266.95 $0.99 $136.88 Add to cart
180 pills - 4 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$183.25 $1.02 $85.97 Add to cart
150 pills - 4 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$157.95 $1.05 $66.40 Add to cart
120 pills - 4 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$127.99 $1.07 $51.49 Add to cart
90 pills - 4 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$101.93 $1.13 $32.68 Add to cart
60 pills - 4 mg $73.32 $1.22 $16.42 Add to cart
30 pills - 4 mg $44.87 $1.50 No Add to cart
Zanaflex 2 mg
270 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$175.95 $0.65 $165.96 Add to cart
180 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$121.75 $0.68 $106.19 Add to cart
150 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$111.99 $0.75 $77.96 Add to cart
120 pills - 2 mg $99.43 $0.83 $52.53 Add to cart
90 pills - 2 mg $82.95 $0.92 $31.02 Add to cart
60 pills - 2 mg $61.11 $1.02 $14.87 Add to cart
30 pills - 2 mg $37.99 $1.27 No Add to cart

Product description

Drug Name

Zanaflex (Tizanidine)

Pharmacological action

A myorelaxant of central action. Its main point of action is in the spinal cord. By stimulating presynaptic α2-adrenoreceptors, it inhibits the release of excitatory amino acids that stimulate receptors for N-methyl-D-aspartate (NMDA-receptors). As a consequence, polysynaptic excitation transmission is suppressed at the level of intermediate spinal cord neurons. Since it is this mechanism that is responsible for excess muscle tone, when it is suppressed, muscle tone decreases. In addition to its myorelaxant properties, tizanidine also has a central moderately pronounced analgesic effect.


Zanaflex (Tizanidine) is effective in chronic spasticity of spinal and cerebral genesis. It reduces spasticity and clonic convulsions, whereby resistance to passive movements decreases and the volume of active movements increases.


Pharmacokinetics

After oral administration, Zanaflex (Tizanidine) is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability is about 34%. Binding to plasma proteins is 30%.


Zanaflex (Tizanidine) is rapidly and largely (about 95%) metabolized in the liver. In vitro tizanidine is metabolized mainly by CYP1A2 isoenzyme of cytochrome P450 system. Metabolites are inactive.


T1/2 is on average 2-4 hours. Excreted by the kidneys (approximately 70% of the dose) as metabolites, about 4.5% unchanged.

Contraindications for use

Hypersensitivity to Zanaflex (Tizanidine); severe hepatic dysfunction, concomitant use with potent CYP1A2 isoenzyme inhibitors (such as fluvoxamine or ciprofloxacin); children and adolescents under 18 years of age.


Caution: in patients older than 65 years, patients with impaired renal function, patients with moderate liver function abnormality. Caution should be exercised when concomitant use with drugs that prolong the QT interval (e.g., cisapride, amitriptyline, azithromycin).


Administration during pregnancy and lactation

During pregnancy, it should be used only after consultation with a physician in cases when the estimated benefit to the mother exceeds the potential risk to the fetus or infant.


It is contraindicated for use during lactation (breast-feeding).


Administration in patients with liver dysfunction

It is contraindicated in patients with severe liver dysfunction. Caution is advised when using in patients with moderate liver dysfunction. It is recommended to start therapy with the minimum dose, with gradual increase until an optimal balance between tolerability and efficacy is achieved.


Administration in renal dysfunction

Use with caution in patients with impaired renal function. It is recommended to start therapy with minimum dose, with gradual increase up to reaching of the optimal ratio of tolerability and therapy efficiency.

Administration in children

Administration in children and adolescents under 18 years old is contraindicated.


Administration in elderly patients

Caution is advised when using in patients over 65 years of age. It is recommended to start therapy with the minimum dose, with gradual increase until the optimal ratio of tolerability and efficacy of therapy is achieved.

Indications of active substances of Zanaflex (Tizanidine)

Spastic condition of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord). Painful skeletal muscle spasm due to spinal disorders (cervical and lumbar syndromes) or following surgery (herniated disc or osteoarthritis of the hip).

Dosing regimen

The optimal dosing regimen is determined by the doctor. It should be strictly observed in accordance with the dosage form used for the particular drug indications and the dosing regimen.

The dose, regimen and duration of therapy are determined individually, depending on the indications, clinical situation and the dosage form used.