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Verapamil

Verapamil
Verapamil is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.

Brand: Arpamyl

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
Package Price Per pill Save Order
Verapamil 120 mg
480 pills - 120 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$278.99 $0.58 $88.85 Add to cart
240 pills - 120 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$143.56 $0.60 $40.36 Add to cart
120 pills - 120 mg $73.91 $0.62 $18.05 Add to cart
90 pills - 120 mg $59.99 $0.67 $8.98 Add to cart
60 pills - 120 mg $41.93 $0.70 $4.05 Add to cart
30 pills - 120 mg $22.99 $0.77 No Add to cart
Verapamil 40 mg
240 pills - 40 mg $61.91 $0.26 $26.05 Add to cart
120 pills - 40 mg $33.95 $0.28 $10.03 Add to cart
90 pills - 40 mg $27.95 $0.31 $5.04 Add to cart
60 pills - 40 mg $21.99 $0.37 No Add to cart

Product description

Drug Title

Verapamil (Arpamyl)

Pharmacological action

Verapamil is one of the main drugs in the group of calcium channel blockers. It has antiarrhythmic, antianginal and antihypertensive activity.


The drug reduces myocardial oxygen demand by reducing myocardial contractility and heart rate. Causes dilatation of coronary vessels of the heart and increases coronary blood flow; reduces smooth muscle tone of peripheral arteries and total peripheral vascular resistance.


Verapamil significantly slows down AV conductivity and inhibits sinus node automatism, which allows using the drug for treatment of supraventricular arrhythmias.


Verapamil is the drug of choice for treatment of angina of vasospastic genesis (Prinzmetal's angina). It has an effect in angina pectoris, as well as in treatment of angina with supraventricular arrhythmias.


Pharmacokinetics

When administered orally, more than 90% of the administered dose is absorbed. It is metabolized during the "first passage" through the liver. Protein binding is 90%. T1/2 in a single dose is 2.8-7.4 hours; in repeated doses 4.5-12 hours. It is eliminated mainly by the kidneys and 9-16% through the intestines. The main metabolite is norverapamil, which has less pronounced hypotensive activity than unchanged verapamil.

Contraindications to use

  • Chronic heart failure stage IIB-III;
  • Cardiogenic shock (except that caused by arrhythmia);
  • sinotrial blockade;
  • AV blockade of II and III degree (excluding patients with an artificial pacemaker);
  • sinus node weakness syndrome;
  • Wolff-Parkinson-White syndrome;
  • Morgania-Adams-Stokes syndrome;
  • acute heart failure;
  • concomitant use of beta-adrenoblockers (IV);
  • children under 18 years of age;
  • Hypersensitivity to the components of the drug.

The preparation should be used with caution in patients with 1st degree AV-blockade, 1st and 2nd degree chronic heart failure, arterial hypotension (systolic pressure less than 100 mm Hg), bradycardia, severe liver dysfunction.


Administration during pregnancy and lactation

Verapamil can be used during pregnancy only when the expected benefits to the mother outweigh the potential risk to the fetus.


If it is necessary to use the drug during breast-feeding, it should be taken into account that verapamil is excreted with the breast milk, so breast-feeding should be stopped.


Administration in liver dysfunction

Caution should be exercised when prescribing the drug in patients with significant hepatic dysfunction. In patients with significant hepatic impairment, elimination of verapamil from the body is slower, so it is reasonable to start treatment with the minimum dose. The daily dose should not exceed 120 mg.

Administration in children

It is contraindicated in children under 18 years of age.

Indications of Verapamil

Treatment and prevention of cardiac rhythm disorders: paroxysmal supraventricular tachycardia, atrial flutter and fibrillation (tachyarrhythmic version), supraventricular extrasystole;

treatment and prevention of chronic stable angina (angina pectoris), unstable angina (angina pectoris at rest); vasospastic angina (angina Prinzmetal, variant angina);

treatment of arterial hypertension.


Dosing regimen

Verapamil is taken orally during or after meals with a small amount of water.


Dosing regimen and duration of treatment are set individually depending on the patient's condition, severity, peculiarities of the course of the disease and effectiveness of therapy.


For prevention of angina and arrhythmia attacks and for treatment of arterial hypertension, the drug is prescribed to adults in the initial dose of 40-80 mg three to four times a day. If necessary, the single dose is increased to 120-160 mg. Maximum daily dose is 480 mg.


In patients with significant liver dysfunction, verapamil elimination from the body is slow, so it is reasonable to start treatment with the minimum dose. The daily dose should not exceed 120 mg.