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Vasotec

Vasotec
The drug belongs to a group of drugs called ACE inhibitors. It is used to treat high blood pressure (hypertension) in adults and children. It works by relaxing blood vessels and causing them to expand. Reducing high blood pressure helps prevent strokes, heart attacks and kidney problems.

Brand: Enalapril

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Package Price Per pill Save Order
Vasotec 10 mg
360 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$227.92 $0.63 $155.96 Add to cart
270 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$174.55 $0.65 $113.36 Add to cart
180 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$121.97 $0.68 $69.97 Add to cart
120 pills - 10 mg $87.91 $0.73 $40.05 Add to cart
90 pills - 10 mg $69.93 $0.78 $26.04 Add to cart
60 pills - 10 mg $51.95 $0.87 $12.03 Add to cart
30 pills - 10 mg $31.99 $1.07 No Add to cart
Vasotec 5 mg
360 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$179.91 $0.50 $155.49 Add to cart
270 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$142.53 $0.53 $109.02 Add to cart
180 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$103.95 $0.58 $63.75 Add to cart
120 pills - 5 mg $75.99 $0.63 $35.81 Add to cart
90 pills - 5 mg $60.93 $0.68 $22.92 Add to cart
60 pills - 5 mg $45.99 $0.77 $9.91 Add to cart
30 pills - 5 mg $27.95 $0.93 No Add to cart
Vasotec 2.5 mg
360 pills - 2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$168.99 $0.47 $130.89 Add to cart
270 pills - 2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$135.55 $0.50 $89.36 Add to cart
180 pills - 2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$101.99 $0.57 $47.95 Add to cart
120 pills - 2.5 mg $74.95 $0.62 $25.01 Add to cart
90 pills - 2.5 mg $59.93 $0.67 $15.04 Add to cart
60 pills - 2.5 mg $42.97 $0.72 $7.01 Add to cart
30 pills - 2.5 mg $24.99 $0.83 No Add to cart

Product description

Drug Title

Vasotec (Enalapril)

Pharmacological action

ACE inhibitor. It is a prodrug from which the active metabolite enalaprilat is formed in the body. It is believed that the mechanism of antihypertensive action is related to competitive inhibition of ACE activity, which decreases the rate of conversion of angiotensin I into angiotensin II (which has a marked vasoconstrictor effect and stimulates aldosterone secretion in the adrenal cortex).


The decrease in angiotensin II concentration results in a secondary increase in plasma renin activity by eliminating the negative feedback of renin release and directly decreasing aldosterone secretion. In addition, enalaprilat appears to influence the kinin-callicrein system by inhibiting the breakdown of bradykinin.


Due to its vasodilator effect, it decreases RPO (post-load), congestion pressure in the pulmonary capillaries (preload) and resistance in the pulmonary vessels; it increases cardiac minute volume and exercise tolerance.


In patients with chronic heart failure, long-term use of enalapril increases exercise tolerance and reduces the severity of heart failure (as assessed by NYHA criteria). Enalapril in patients with mild to moderate heart failure slows its progression and also slows the development of left ventricular dilatation. At left ventricular dysfunction enalapril decreases risk of major ischemic outcomes (including the rate of myocardial infarction and the number of hospitalizations for unstable angina).


Pharmacokinetics

When administered orally about 60% is absorbed from the gastrointestinal tract. Absorption is not affected by simultaneous food intake. It is metabolized in the liver by hydrolysis to form enalaprilat, which has pharmacological activity resulting in hypotensive effect. Binding of enalaprilat to plasma proteins is 50-60%.


T1/2 of enalaprilat is 11 h and increases in renal insufficiency. After oral administration, 60% of the dose is excreted by the kidneys (20% as enalapril, 40% as enalaprilat), 33% is excreted through the intestine (6% as enalapril, 27% as enalaprilat). After intravenous administration of enalaprilat 100% is excreted unchanged by the kidneys.


Contraindications to use

Angioneurotic edema in anamnesis, bilateral renal artery stenosis or stenosis of the renal artery of the only kidney, hyperkalemia, porphyria, concomitant use with aliskiren in patients with diabetes or impaired renal function (CK <60 ml/min), pregnancy, lactation (breast-feeding), children and adolescents below 18 years, hypersensitivity to enalapril and other ACE inhibitors.


Administration during pregnancy and lactation

It is contraindicated for use during pregnancy. If pregnancy occurs, the use of enalapril should be stopped immediately.


Enalapril is excreted with breast milk. If it is necessary to use it during lactation, discontinuation of breastfeeding should be considered.


Administration in liver dysfunction

Use with special caution in patients with hepatic dysfunction.


Administration in children

Safety and efficacy of enalapril use in children have not been established.

Indications of active substances of Vasotec (Enalapril)

Arterial hypertension (including renovascular), chronic heart failure (in combined therapy).


Prevention of the development of clinically significant heart failure in patients with asymptomatic left ventricular dysfunction (as part of combination therapy).


Prevention of coronary ischemia in patients with left ventricular dysfunction in order to reduce the rate of myocardial infarction and reduce the rate of hospitalizations for unstable angina.


Dosing regimen

The optimal dosing regimen is determined by the doctor. It should be strictly adhered to in accordance with the dosage form used for the particular drug indications and the dosing regimen.

When administered orally, the initial dose is 2.5-5 mg once daily. The average dose is 10-20 mg per day in two doses.


The maximum daily dose when administered orally is 80 mg.