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Trimox

Trimox
Trimox is used to treat infections caused by certain bacteria. It is also used with other medications for the treatment of Helicobacter pylori infection and ulcers of the small intestine.

Brand: Amoxicillin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: April 2024
Package Price Per pill Save Order
Trimox 500 mg
270 pills - 500 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$219.75 $0.81 $152.18 Add to cart
180 pills - 500 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$150.98 $0.84 $96.97 Add to cart
120 pills - 500 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$103.97 $0.87 $61.33 Add to cart
90 pills - 500 mg $81.91 $0.91 $42.07 Add to cart
60 pills - 500 mg $57.95 $0.97 $24.70 Add to cart
30 pills - 500 mg $35.99 $1.20 $5.34 Add to cart
20 pills - 500 mg $27.55 $1.38 No Add to cart
Trimox 250 mg
270 pills - 250 mg
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$101.93 $0.38 $82.53 Add to cart
180 pills - 250 mg $75.55 $0.42 $47.42 Add to cart
120 pills - 250 mg $57.93 $0.48 $24.05 Add to cart
90 pills - 250 mg $48.95 $0.54 $12.54 Add to cart
60 pills - 250 mg $40.99 $0.68 No Add to cart

Product description

Drug Title

Trimox (Amoxicillin)

Pharmacological action

It is a broad-spectrum semi-synthetic penicillin antibiotic. It is a 4-hydroxyl analog of ampicillin. It has a bactericidal effect. It is active against aerobic gram-positive bacteria: Staphylococcus spp. (except for strains producing penicillinase), Streptococcus spp.; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.


Microorganisms producing penicillinase are resistant to amoxicillin.


In combination with metronidazole shows activity against Helicobacter pylori. It is believed that amoxicillin inhibits the development of resistance of Helicobacter pylori to metronidazole.


Cross-resistance exists between amoxicillin and ampicillin.


The spectrum of antibacterial action expands with the simultaneous use of amoxicillin and clavulanic acid beta-lactamase inhibitor. This combination increases the activity of amoxicillin against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.


Pharmacokinetics

When administered orally amoxicillin is quickly and completely absorbed from the gastrointestinal tract, it is not destroyed in the acidic environment of the stomach. Cmax of amoxicillin in plasma is reached after 1-2 hours. When increasing the dose by 2 times the concentration also increases by 2 times. In the presence of food in the stomach it does not reduce total absorption. Similar concentrations of amoxicillin are achieved in the blood when administered intravenously, intramuscularly and by oral administration.


Binding of amoxicillin with plasma proteins is about 20%.


It is widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported.


T1/2 from plasma is 1-1.5 h. About 60% of the oral dose is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the urinary concentration of amoxicillin is more than 300 µg/ml. Some amount of amoxicillin is detected in the feces.


The T1/2 may be longer in neonates and the elderly.


In renal failure T1/2 may be 7-20 hours.


Small amounts of amoxicillin penetrate through the BBB in inflammation of the dura mater.


Amoxicillin is eliminated by hemodialysis.

Contraindications to use

Infectious mononucleosis, lympholeukosis, severe gastrointestinal infections accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and/or cephalosporins.


For use in combination with metronidazole: diseases of the nervous system; hematopoiesis disorders, lympholeukosis, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives.


For use in combination with clavulanic acid: history of liver dysfunction and jaundice associated with taking amoxicillin in combination with clavulanic acid.


Use during pregnancy and lactation

Amoxicillin penetrates through the placental barrier, in small amounts is excreted with breast milk.


If it is necessary to use amoxicillin during pregnancy the therapy should be carefully weighed against the expected benefits to the mother and the potential risk to the fetus.


With caution use amoxicillin during lactation (breastfeeding).


Application in liver dysfunction

Amoxicillin in combination with metronidazole should not be used in liver disorders.

Administration in impaired renal function

In patients with impaired renal function, the dose and interval between injections should be adjusted according to the CK values.

Administration in children

Administration in children is possible according to the dosage regimen.


Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years old.

Indications of active substances of Amoxicillin

For use as monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, angina, pyelonephritis, urethritis, GI infections, gynecological infections, infectious skin and soft tissue diseases, listeriosis, leptospirosis, gonorrhea.


For use in combination with metronidazole: chronic gastritis in the acute phase, gastric and duodenal ulcer in the acute phase associated with Helicobacter pylori.


Dosing regimen

The optimal dosing regimen is determined by the doctor. Should be strictly in accordance with the drug used dosage form of a particular drug indications for use and dosing regimen.

Individual. For oral administration a single dose for adults and children over 10 years old (with body mass more than 40 kg) is 250-500 mg, in case of severe course of disease - up to 1 g. For children aged 5-10 years a single dose is 250 mg; for children aged 2 to 5 years - 125 mg. The interval between doses is 8 hours. For children with body weight less than 40 kg a daily dose, depending on indications and clinical situation, can be 20-100 mg/kg in 2-3 doses.


During treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecid). In patients with kidney dysfunction at IQ 10-40 ml/min the interval between the doses should be increased up to 12 hours; in IQ less than 10 ml/min the interval between doses should be 24 hours.


In parenteral use in adults - 1 g 2 times per day in m/m, 2-12 g/day in v/v (with normal renal function). Children: intravenous 50 mg/kg/day, a single dose of 500 mg, infusion frequency 2 times/day; intravenous 100-200 mg/kg/day. In patients with impaired renal function, the dose and interval between injections should be adjusted according to the CK values.