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Tricor

Tricor
Tricor is a lipid-lowering agent that is used for controlling and maintaining the cholesterol level in the body. It is used in combination with a good diet and exercise program.

Brand: Fenofibrate

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Package Price Per pill Save Order
Tricor 200 mg
360 pills - 200 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$459.99 $1.28 $115.41 Add to cart
270 pills - 200 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$351.95 $1.30 $79.60 Add to cart
180 pills - 200 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$239.91 $1.33 $47.79 Add to cart
120 pills - 200 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$161.93 $1.35 $29.87 Add to cart
90 pills - 200 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$129.97 $1.44 $13.88 Add to cart
60 pills - 200 mg $89.91 $1.50 $5.99 Add to cart
30 pills - 200 mg $47.95 $1.60 No Add to cart
Tricor 160 mg
360 pills - 160 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$296.98 $0.82 $134.90 Add to cart
270 pills - 160 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$223.33 $0.83 $100.58 Add to cart
180 pills - 160 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$151.91 $0.84 $64.03 Add to cart
120 pills - 160 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$105.93 $0.88 $38.03 Add to cart
90 pills - 160 mg $81.95 $0.91 $26.02 Add to cart
60 pills - 160 mg $57.97 $0.97 $14.01 Add to cart
30 pills - 160 mg $35.99 $1.20 No Add to cart

Product description

Drug Title

Tricor (Fenofibrate)

Pharmacological action

Hypolipidemic drug from the group of fibric acid derivatives.


By activating RAPP-alpha (α-receptors activated by peroxisome proliferator), Tricor (Fenofibrate) increases lipolysis and excretion of atherogenic lipoproteins with high triglyceride concentration from blood plasma by activating lipoprotein lipase and decreasing synthesis of apoprotein CIII. Activation of RAPP-alpha also leads to increased synthesis of apoproteins AI and AII.


Tricor (Fenofibrate) is a derivative of fibric acid whose ability to change lipid concentration in humans is mediated by activation of RAPP-alpha. The above described effects of Tricor (Fenofibrate) on lipoproteins lead to a decrease in the concentration of LDL and LDL, which include apoprotein B, and an increase in the concentration of HDL, which include apoproteins AI and AII.


In addition, by correcting the disorders of synthesis and catabolism of LDL, fenofibrate increases clearance of LDL and reduces the concentration of dense and small particles of LDL, the increase of which is observed in patients with atherogenic lipid phenotype, a frequent disorder in patients at risk of CHD.


Tricor (Fenofibrate) reduces platelet aggregation, decreases elevated plasma fibrinogen levels, can slightly lower blood glucose levels in diabetic patients; reduces blood uric acid levels.


Pharmacokinetics

After oral administration, Tricor (Fenofibrate) is rapidly hydrolyzed by esterases. In blood plasma only main active metabolite of fenofibrate - fenofibroic acid is detected. Tricor (Fenofibrate) is not a substrate for CYP3A4 isoenzyme and does not participate in microsomal metabolism. Initial Tricor (Fenofibrate) is not detected in blood plasma. Cmax in plasma is reached 2-4 hours after oral administration. With long-term use, plasma concentrations remain stable regardless of the individual characteristics of the patient. Binding with plasma proteins (albumin) is high - more than 99%. It is excreted mainly by the kidneys as fenofibroic acid and glucuronide conjugate. Within 6 days, fenofibrate is eliminated almost completely.

Contraindications to use

Hypersensitivity to Tricor (Fenofibrate); severe hepatic impairment - Child-Pugh class C (including biliary cirrhosis and persistent hepatic impairment of unclear etiology); history of gallbladder disease; severe to moderate renal impairment (CK <60 ml/min); chronic or acute pancreatitis, except for cases of acute pancreatitis due to severe hypertriglyceridemia; history of photosensitivity or phototoxicity during treatment with fibrates or ketoprofen; breast-feeding period; age under 18 years old.


Caution


In patients with predisposing factors to myopathy and/or rhabdomyolysis, including age over 70 years, history of hereditary muscle disease, hypothyroidism and alcohol abuse; use in pregnancy; concomitant use of oral anticoagulants, HMG-CoA reductase inhibitors


Administration during pregnancy and lactation

The potential risk for humans is unknown, therefore, the use during pregnancy is possible only after careful evaluation of the ratio of the expected benefit of the therapy for the mother and the probable risk for the fetus.


Fenofibrate is contraindicated during breastfeeding.


Use in liver dysfunction

Severe hepatic impairment with Child-Pugh class C (including biliary cirrhosis and persistent hepatic impairment of unclear etiology) is contraindicated.

Administration in patients with impaired renal function

It is contraindicated in severe and moderate renal dysfunction (CKD <60 ml/min).

Administration in children

Contraindicated in children and teenagers under 18 years old.

Administration in elderly patients

Caution in patients over the age of 70 years old.

Indications of active substance Tricor (Fenofibrate)

Hypercholesterolemia and hypertriglyceridemia isolated or mixed (dyslipidemia types IIa, IIb, III, IV, V according to Fredrickson classification) in patients for whom diet or other non-pharmacological therapeutic measures (such as decreasing the body weight or increasing physical activity) are not effective, especially if the risk factors connected to dyslipidemia, such as hypertension and smoking, are present.


For treatment of secondary hyperlipoproteinemia, the drug is used when hyperlipoproteinemia persists despite effective treatment of the underlying disease (e.g., dyslipidemia in diabetes mellitus).


Dosing regimen

Before and during treatment, the patient should follow a hypocholesterolemic diet.


It is taken orally once a day.


The dose depends on the applied dosage form.


Treatment is long. The effectiveness of therapy should be assessed by the concentration of lipids (total cholesterol, LDL, triglycerides) in blood serum. If there is no therapeutic effect after several months of therapy (usually after 3 months), the advisability of prescribing concomitant or alternative therapy should be considered.