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Tenormin is prescribed to the patients having high blood pressure (hypertension). It is also used for the treatment of chest pains (stenocardia) during heart ischemic disease. Tenormin is useful as well for slowing and regulating of tachycardia specific types. It is also used for the prevention of migraine and some tremor types treatment (inherited tremor).

Brand: Atenolol

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Tenormin 100 mg
280 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$143.79 $0.51 $136.01 Add to cart
140 pills - 100 mg $82.96 $0.59 $56.94 Add to cart
98 pills - 100 mg $61.55 $0.63 $36.38 Add to cart
84 pills - 100 mg $55.97 $0.67 $27.97 Add to cart
56 pills - 100 mg $41.91 $0.75 $14.05 Add to cart
28 pills - 100 mg $23.95 $0.86 $4.03 Add to cart
14 pills - 100 mg $13.99 $1.00 No Add to cart
Tenormin 50 mg
280 pills - 50 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$120.79 $0.43 $109.01 Add to cart
140 pills - 50 mg $65.97 $0.47 $48.93 Add to cart
98 pills - 50 mg $50.55 $0.52 $29.88 Add to cart
84 pills - 50 mg $47.95 $0.57 $20.99 Add to cart
56 pills - 50 mg $34.13 $0.61 $11.83 Add to cart
28 pills - 50 mg $19.15 $0.68 $3.83 Add to cart
14 pills - 50 mg $11.49 $0.82 No Add to cart
Tenormin 25 mg
280 pills - 25 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$111.55 $0.40 $88.25 Add to cart
140 pills - 25 mg $65.99 $0.47 $33.91 Add to cart
98 pills - 25 mg $47.55 $0.49 $22.38 Add to cart
84 pills - 25 mg $43.99 $0.52 $15.95 Add to cart
56 pills - 25 mg $29.99 $0.54 $9.97 Add to cart
28 pills - 25 mg $15.95 $0.57 $4.03 Add to cart
14 pills - 25 mg $9.99 $0.71 No Add to cart

Product description

Drug title

Tenormin (Atenolol)

Pharmacological action

Cardioselective beta1-adrenoblocker without intrinsic sympathomimetic activity. It has antihypertensive, antianginal and antiarrhythmic effects.

It reduces the stimulating effect on the heart of sympathetic innervation and circulating catecholamines in the blood. It has negative chrono-, dromo-, batmo- and inotropic effects: reduces HR, inhibits conduction and excitability, reduces myocardial contractility. ROS increases at the beginning of beta-adreno-blocker use (during the first 24 hours after oral administration) (as a result of reciprocal increase in α-adrenoreceptor activity and elimination of β2-adrenoreceptor stimulation), after 1-3 days returns to baseline, and decreases with prolonged use.

Hypotensive effect is associated with decreased minute blood volume, decreased activity of renin-angiotensin system (of greater importance for patients with baseline renin hypersecretion), sensitivity of aortic arch baroreceptors (there is no increase in their activity in response to BP reduction) and the effect on CNS, manifested by lowering of both systolic and diastolic BP, decreased stroke volume and minute volume. In medium therapeutic doses, it has no effect on peripheral arterial tone.

The antianginal effect is determined by a decrease in myocardial oxygen demand due to a decrease in HR (prolongation of diastole and improvement of myocardial perfusion) and contractility, as well as by a decrease in myocardial sensitivity to sympathetic innervation. Reduction of HR occurs at rest and during physical activity. Due to increased left ventricular end-diastolic pressure and increased stretching of ventricular muscle fibers, it may increase oxygen demand, especially in patients with chronic heart failure.

Antiarrhythmic effect is caused by the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased content of CAMF, arterial hypertension), reduction of the rate of spontaneous excitation of sinus and ectopic pacemakers and slowdown of AV conduction. Inhibition of impulse conduction is marked mainly in antegrade and, to a lesser extent, in retrograde direction through AV node and along additional pathways.

In contrast to non-selective beta-adrenoblockers, when administered in medium therapeutic doses, it has less pronounced effect on organs containing β2-adrenoreceptors (pancreas, skeletal muscles, smooth muscle of peripheral arteries, bronchi and uterus) and on carbohydrate metabolism; the degree of atherogenic action does not differ from that of propranolol. Negative butmo-, chrono-, ino- and dromotropic effects are less pronounced. When used in high doses (more than 100 mg/day), it causes blockade of both β-adrenoreceptor subtypes.

Hypotensive effect lasts for 24 hours and stabilizes by the end of 2 weeks of treatment with regular administration. Negative chronotropic effect appears 1 hour after intake, reaches its maximum after 2-4 hours and lasts up to 24 hours.


After oral administration, absorption from the gastrointestinal tract is 50-60%, bioavailability is 40-50%. It is practically not metabolized in the body. It poorly penetrates through the BBB. Binding to plasma proteins is 6-16%.

T1/2 is 6-9 hours. It is eliminated mainly by kidneys unchanged. Renal dysfunction is mainly accompanied by increase in T1/2 and cumulation: in IQ less than 35 ml/min the T1/2 is 16-27 h, in IQ less than 15 ml/min - more than 27 h, in anuria it is prolonged to 144 h. It is excreted during hemodialysis.

T1/2 is longer in elderly patients.

Contraindications to use

II and III degree AV-blockade, sinoatrial block, CAD, bradycardia (heart rate less than 40 beats/min), arterial hypotension (if used in myocardial infarction, systolic BP less than 100 mm Hg). ), cardiogenic shock, chronic heart failure stages IIB-III, acute heart failure, Prinzmetal angina, lactation, concomitant use of MAO inhibitors, hypersensitivity to atenololol.

Administration during pregnancy and lactation

Atenolol crosses the placental barrier, so its use during pregnancy is possible only if the expected benefits to the mother exceed the possible risk to the fetus.

Atenolol is excreted with the breast milk, so if it is necessary to use during lactation, it is recommended to stop breastfeeding.

Administration in patients with hepatic impairment

Caution should be exercised when there is hepatic insufficiency.

Administration in patients with impaired renal function

Caution should be exercised when using in chronic renal failure. In patients with impaired renal function, in patients with CKD 15-35 ml/min - 50 mg per day; in patients with CKD less than 15 ml/min - 50 mg per day.

Administration in children

Caution should be exercised when used in pediatrics (effectiveness and safety have not been determined).

Administration in elderly patients

Caution should be exercised when using in elderly patients.

Indications of the active substances of the drug Tenormin

Arterial hypertension, hypertensive crisis, mitral valve prolapse, hyperkinetic cardiac syndrome of functional genesis, neurocirculatory dystonia of the hypertensive type.

Treatment: CHD, angina pectoris (tension, resting and unstable).

Treatment and prevention: myocardial infarction (acute phase with stable hemodynamic parameters, secondary prevention).

Arrhythmias (including. In general anesthesia, congenital long QT interval syndrome, myocardial infarction without signs of chronic heart failure, thyrotoxicosis), sinus tachycardia, paroxysmal atrial tachycardia, supraventricular and ventricular extrasystoles, supraventricular and ventricular tachycardia, atrial fibrillation, atrial flutter.

Essential and senile tremor, agitation and tremor in withdrawal syndrome.

As part of complex therapy: hypertrophic obstructive cardiomyopathy, pheochromocytoma (only together with alpha-adrenoblockers), thyrotoxicosis; migraine (prevention).

Dosing regimen

The optimal dosing regimen is determined by the doctor. Should be strictly in accordance with the drug used dosage form of a particular drug indications for use and the dosing regimen.

It is set individually. The usual dosage for adults is oral; at the beginning of treatment it is 25-50 mg once a day. If necessary, the dose is gradually increased. In patients with impaired renal function, 50 mg/day in patients with CKD 15-35 ml/min; in patients with CKD less than 15 ml/min - 50 mg every other day.

Maximum dose: adults when taken orally - 200 mg/day in 1 or 2 doses.