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Synthroid

Synthroid
Synthroid treats hypothyroidism (low thyroid hormone). It is also used to treat or prevent goiter (enlarged thyroid gland), which may be caused by an imbalance of hormones, radiation therapy, surgery, or cancer.

Brand: Levothyroxine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
Package Price Per pill Save Order
Synthroid 200 mcg
200 pills - 200 mcg
+ 4 free Viagra 100 mg, 3% discount for future orders
$107.95 $0.54 $15.95 Add to cart
100 pills - 200 mcg $61.95 $0.62 No Add to cart
Synthroid 150 mcg
200 pills - 150 mcg $95.99 $0.48 $23.91 Add to cart
100 pills - 150 mcg $59.95 $0.60 No Add to cart
Synthroid 125 mcg
200 pills - 125 mcg $83.53 $0.42 $20.37 Add to cart
100 pills - 125 mcg $51.95 $0.52 No Add to cart
Synthroid 100 mcg
200 pills - 100 mcg $73.99 $0.37 $17.91 Add to cart
100 pills - 100 mcg $45.95 $0.46 No Add to cart
Synthroid 75 mcg
200 pills - 75 mcg $63.75 $0.32 $13.35 Add to cart
100 pills - 75 mcg $38.55 $0.39 No Add to cart
Synthroid 50 mcg
200 pills - 50 mcg $61.45 $0.31 $13.61 Add to cart
100 pills - 50 mcg $37.53 $0.38 No Add to cart
Synthroid 25 mcg
200 pills - 25 mcg $54.95 $0.27 $12.95 Add to cart
100 pills - 25 mcg $33.95 $0.34 No Add to cart

Product description

DRUG TITLE

Synthroid (Levothyroxine)

Pharmacological action

Preparation of thyroid hormones. A synthetic left-handed isomer of thyroxine. In small doses it has an anabolic effect. In medium doses it stimulates growth and development, increases tissue oxygen demand, stimulates metabolism of proteins, fats and carbohydrates, stimulates cardiovascular system and CNS. At high doses, it inhibits hypothalamic TTH and pituitary TTH production.

Pharmacokinetics

After oral administration is absorbed from the gastrointestinal tract, absorption is 48-79%. Fasting intake increases absorption of the active substance. Cmax in plasma is reached after about 6 hours. Binding with plasma proteins (thyroxine-binding globulin, thyroxine-binding prealbumin and albumin) is more than 99%. Vd is 0.5 l/kg. Distribution occurs mainly in the liver, brain and muscles.

In various tissues approximately 80% of levothyroxine sodium is monodeoxidized to form triiodothyronine (T3) and inactive products. A small amount of the active substance undergoes deamination and decarboxylation to form tetraiodothyroacetic acid, as well as conjugation with sulfuric and glucuronic acids (in the liver).

T1/2 is 6-7 days. About 15% is excreted by the kidneys and with bile unchanged and as conjugates.


Contraindications to use

Hypersensitivity to sodium Levothroid (Levothyroxine), untreated thyrotoxicosis, acute myocardial infarction, acute myocarditis, untreated insufficiency of the adrenal cortex.


Caution: in diseases of the cardiovascular system - CHD (atherosclerosis, angina pectoris, myocardial infarction in anamnesis), arterial hypertension, arrhythmia; in diabetes, severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).

Administration during pregnancy and lactation

During pregnancy and lactation (breast-feeding) levothyroxine sodium should be used with caution, strictly in the recommended doses, under medical supervision.


It is contraindicated during pregnancy due to increased risk of fetal hypothyroidism.


Administration in children

It is possible to use in children on prescription in dosages and dosage forms recommended according to the age

Indications of active substances of Levothroid (Levothyroxine)

Hypothyroidism; euthyroid goiter; as replacement therapy and for prevention of goiter recurrence after thyroid resection; thyroid cancer (after surgical treatment); diffuse toxic goiter: after achieving euthyroid state with antithyroid drugs (as combined or monotherapy); as a diagnostic agent for thyroid suppression test.

Dosing regimen

It is established individually depending on the indications. It is administered in a dose of 12.5-200 mcg 1 time per day 20-30 min before meals.

During differential-diagnostic test of thyroid suppression - once in a dose of 3 mg or 200 mcg 1 time per day during 2 weeks.