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200 pills - 200 mcg
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Preparation of thyroid hormones. A synthetic left-handed isomer of thyroxine. In small doses it has an anabolic effect. In medium doses it stimulates growth and development, increases tissue oxygen demand, stimulates metabolism of proteins, fats and carbohydrates, stimulates cardiovascular system and CNS. At high doses, it inhibits hypothalamic TTH and pituitary TTH production.
After oral administration is absorbed from the gastrointestinal tract, absorption is 48-79%. Fasting intake increases absorption of the active substance. Cmax in plasma is reached after about 6 hours. Binding with plasma proteins (thyroxine-binding globulin, thyroxine-binding prealbumin and albumin) is more than 99%. Vd is 0.5 l/kg. Distribution occurs mainly in the liver, brain and muscles.
In various tissues approximately 80% of levothyroxine sodium is monodeoxidized to form triiodothyronine (T3) and inactive products. A small amount of the active substance undergoes deamination and decarboxylation to form tetraiodothyroacetic acid, as well as conjugation with sulfuric and glucuronic acids (in the liver).
T1/2 is 6-7 days. About 15% is excreted by the kidneys and with bile unchanged and as conjugates.
Contraindications to use
Hypersensitivity to sodium Levothroid (Levothyroxine), untreated thyrotoxicosis, acute myocardial infarction, acute myocarditis, untreated insufficiency of the adrenal cortex.
Caution: in diseases of the cardiovascular system - CHD (atherosclerosis, angina pectoris, myocardial infarction in anamnesis), arterial hypertension, arrhythmia; in diabetes, severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).
Administration during pregnancy and lactation
During pregnancy and lactation (breast-feeding) levothyroxine sodium should be used with caution, strictly in the recommended doses, under medical supervision.
It is contraindicated during pregnancy due to increased risk of fetal hypothyroidism.
Administration in children
It is possible to use in children on prescription in dosages and dosage forms recommended according to the age
Indications of active substances of Levothroid (Levothyroxine)
Hypothyroidism; euthyroid goiter; as replacement therapy and for prevention of goiter recurrence after thyroid resection; thyroid cancer (after surgical treatment); diffuse toxic goiter: after achieving euthyroid state with antithyroid drugs (as combined or monotherapy); as a diagnostic agent for thyroid suppression test.
It is established individually depending on the indications. It is administered in a dose of 12.5-200 mcg 1 time per day 20-30 min before meals.
During differential-diagnostic test of thyroid suppression - once in a dose of 3 mg or 200 mcg 1 time per day during 2 weeks.