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Stromectol

Stromectol
Stromectol is an anthelmintic, is used for treating infections caused by certain parasites.

Brand: Ivermectin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: March 2024
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Package Price Per pill Save Order
Stromectol 12 mg
180 pills - 12 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$733.95 $4.08 $230.13 Add to cart
120 pills - 12 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$494.99 $4.12 $147.73 Add to cart
90 pills - 12 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$374.95 $4.17 $107.09 Add to cart
60 pills - 12 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$254.25 $4.24 $67.11 Add to cart
30 pills - 12 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$133.57 $4.45 $27.11 Add to cart
20 pills - 12 mg $93.65 $4.68 $13.47 Add to cart
10 pills - 12 mg $53.56 $5.36 No Add to cart
Stromectol 6 mg
270 pills - 6 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$699.99 $2.59 $360.84 Add to cart
180 pills - 6 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$471.93 $2.62 $235.29 Add to cart
120 pills - 6 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$318.55 $2.65 $152.93 Add to cart
90 pills - 6 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$242.35 $2.69 $111.26 Add to cart
60 pills - 6 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$165.75 $2.76 $69.99 Add to cart
30 pills - 6 mg $89.99 $3.00 $27.88 Add to cart
20 pills - 6 mg $64.64 $3.23 $13.94 Add to cart
10 pills - 6 mg $39.29 $3.93 No Add to cart
Stromectol 3 mg
270 pills - 3 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$615.96 $2.28 $315.81 Add to cart
180 pills - 3 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$415.55 $2.31 $205.63 Add to cart
120 pills - 3 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$279.99 $2.33 $134.13 Add to cart
90 pills - 3 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$213.53 $2.37 $97.06 Add to cart
60 pills - 3 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$145.75 $2.43 $61.31 Add to cart
30 pills - 3 mg $78.55 $2.62 $24.98 Add to cart
20 pills - 3 mg $57.21 $2.86 $11.81 Add to cart
10 pills - 3 mg $34.51 $3.45 No Add to cart

Product description

Drug Title

Stromectol (Ivermectin)

Pharmacological action

The drug for external use, belongs to the group of avermectin. It has an anti-inflammatory effect by inhibiting the production of inflammatory cytokines induced by lipopolysaccharides. The anti-inflammatory properties of ivermectin for external use have been observed in animal models of inflammatory skin processes. Ivermectin also causes death of parasites, mainly through selective binding and high affinity to glutamate-regulated chlorine channels found in invertebrate nerve and muscle cells. The mechanism of action of ivermectin in the treatment of inflammatory skin lesions in rosacea is unknown, but may be related both to the anti-inflammatory effects of ivermectin and to the ability of ivermectin to cause death of Demodex mites, which in turn are a factor causing skin inflammation.

Pharmacokinetics

After external administration of ivermectin, equilibrium Cmax (after 2 weeks of treatment) in plasma was observed within 10±8 h after drug administration (Cmax 2.1±1.0 ng/ml, range 0.7-4.0 ng/ml), and the highest mean (± standard deviation) AUC0-24 h was 36±16 ng×h/mL, range 14-75 ng×h/mL). Systemic exposure to ivermectin reached a plateau by the end of the second week of treatment in the equilibrium state. At equilibrium, systemic exposure levels of ivermectin (AUC0-24 h, 36±16 ng×h/mL) were lower than after a single oral dose of 6 mg of ivermectin in healthy volunteers (AUC0-24 h, 134±66 ng×h/mL).


In vitro binding of ivermectin to plasma proteins (predominantly to albumin) is over 99%. Significant binding of ivermectin to erythrocytes was not observed.


In in vitro studies using human liver microsomes and recombinant CYP450 enzymes it was noted that ivermectin is metabolized mainly with the participation of CYP3A4 inhibitors.


Two major metabolites of ivermectin (3"-O-demethyl ivermectin and 4a-hydroxy ivermectin) have been identified. Similar to the parent compound, the metabolites reached equilibrium status by the end of the second week of treatment; no evidence of accumulation was noted for up to 12 weeks. In addition, systemic metabolite exposures (assessed using Cmax and AUC ) obtained at equilibrium were much lower than those after oral administration of ivermectin.


The final T1/2, on average, was 6 days (approximately 145 h, range 92-238 h) in patients who applied the drug to the skin once daily for 28 days in a clinical pharmacokinetic study at the maximum tolerated dose. Excretion depends on the degree of absorption after external application of ivermectin.

Side effects

Skin and subcutaneous tissue: frequent - a burning sensation of the skin, infrequent - skin irritation, itching, dry skin, unknown - contact dermatitis, allergic reactions, erythema.


Contraindications to use

Hypersensitivity to ivermectin, pregnancy, breast-feeding, children under 18 years of age.


With caution: liver dysfunction.


Application during pregnancy and lactation

Pregnancy and breast-feeding are contraindicated.

Administration in patients with hepatic impairment

Use with caution in patients with impaired liver function.

Use in patients with impaired renal function

No dosage adjustment is required for patients with renal dysfunction.


Administration in children

Contraindications for use in children and adolescents under 18 years of age.

Administration in elderly patients

No dosage adjustment is required for elderly patients.


Special precautions

Wash hands after application of this product.

Indications for the active ingredient IVERMECTIN

Treatment of inflammatory skin lesions in rosacea (papulopustular form) in adult patients.


Dosage regimen

For external use.


It is used daily 1 time per day during the whole course of treatment - up to 4 months. If necessary the course of treatment may be repeated.


If there is no improvement after 3 months of treatment should be discontinued.


Apply only to the face.