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Sinequan

Sinequan
Sinequan is a tricyclic antidepressant that is used to treat the symptoms of depression and help patients elevate their mood.

Brand: Doxepin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Package Price Per pill Save Order
Sinequan 75 mg
360 pills - 75 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$395.99 $1.10 $227.89 Add to cart
270 pills - 75 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$301.55 $1.12 $166.36 Add to cart
180 pills - 75 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$207.97 $1.16 $103.97 Add to cart
120 pills - 75 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$146.93 $1.22 $61.03 Add to cart
90 pills - 75 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$115.91 $1.29 $40.06 Add to cart
60 pills - 75 mg $83.97 $1.40 $20.01 Add to cart
30 pills - 75 mg $51.99 $1.73 No Add to cart
Sinequan 25 mg
360 pills - 25 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$393.95 $1.09 $96.97 Add to cart
270 pills - 25 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$299.55 $1.11 $68.64 Add to cart
180 pills - 25 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$202.91 $1.13 $42.55 Add to cart
120 pills - 25 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$139.97 $1.17 $23.67 Add to cart
90 pills - 25 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$108.93 $1.21 $13.80 Add to cart
60 pills - 25 mg $75.99 $1.27 $5.83 Add to cart
30 pills - 25 mg $40.91 $1.36 No Add to cart
Sinequan 10 mg
360 pills - 10 mg $96.93 $0.27 $82.53 Add to cart
180 pills - 10 mg $54.99 $0.31 $34.74 Add to cart
120 pills - 10 mg $41.95 $0.35 $17.87 Add to cart
90 pills - 10 mg $35.57 $0.40 $9.30 Add to cart
60 pills - 10 mg $29.91 $0.50 No Add to cart

Product description

DRUG TITLE

Sinequan (Doxepin)

Pharmacological action

Antidepressant of tricyclic structure, dibenzoxepine derivative. The mechanism of action appears to be related to the effect on adrenergic transmission in the CNS, in particular to the blockade of neuronal takeover of noradrenaline. It also has anxiolytic, sedative, antispasmodic activity, has m-cholinoblocking effect. It has no stimulating effect on the CNS. It does not inhibit the MAO. Initially, the anxiolytic effect of doxepin is manifested, and the optimal antidepressant effect develops after 2-3 weeks of treatment.


Pharmacokinetics

It is rapidly and completely absorbed from the gastrointestinal tract. Cmax is reached after 1-3 hours. Css (0.03- 0.15 mg/ml) is noted after 2 weeks. Metabolized in the liver with the participation of cytochrome P450 isoenzyme CYP2D6 to pharmacologically active dimethyldoxepine, further glucuronidated and excreted in the urine. T1/2 is 28-52 hours. Distributed in tissues, found in lungs, heart, brain, liver. It penetrates through the BBB.


Contraindications to use

Hypersensitivity to Sinequan (Doxepin); glaucoma, tendency to urinary retention, left bundle branch block, AV blockade of degree III, severe dysfunction of hematopoiesis, liver and kidneys, acute myocardial infarction; pregnancy, breast-feeding, children under 12 years of age.


With caution: severe diseases of the cardiovascular system; emaciated patients; advanced age.


Administration during pregnancy and lactation

Pregnancy and breast-feeding are contraindicated.


Administration in patients with liver dysfunction

Caution should be exercised when using in patients with significant hepatic impairment.


Administration in patients with impaired renal function

Caution should be exercised when using in patients with significant renal dysfunction.


Administration in children

Use in children under 12 years of age is contraindicated.

Administration in elderly patients

Caution should be exercised when prescribing in elderly patients in order to avoid worsening of concomitant diseases.

Indications for the active substance Sinequan (Doxepin)

Depression, anxiety and sleep disorders in neurosis, alcoholism, organic CNS diseases, psychoneurotic disorders with anxiety, depression, psychotic depression (including involutional, reactive-depressive phase of manic-depressive psychosis).


In general therapeutic practice - duodenal ulcer, dumping syndrome, premenstrual syndrome, chronic pain in cancer patients, skin itching, chronic idiopathic urticaria.


Dosage regimen

Orally. The dose and scheme of administration are determined individually, depending on the indications and clinical situation.


The initial dose is 75 mg/day in case of moderately severe depression and/or anxiety. Further, the effective dose is chosen individually, which is usually 75-150 mg/day. The dose is increased gradually. In severely depressed and/or anxious patients the effective dose can be up to 300 mg/day. In patients with minimally expressed disorders, smaller doses of 25-50 mg/day may be effective. The frequency of administration is 1-2 times/day (if administered once daily, the dose of doxepin should not exceed 150 mg).


In case of sleep disorders, most of the daily dose is taken in the evening.