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Seroquel

Seroquel
Seroquel is used to treat schizophrenia and bipolar disorder. It can also be used for other purposes as defined by your doctor.

Brand: Quetiapine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: March 2024
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Seroquel 300 mg
120 pills - 300 mg
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$377.57 $3.15 $286.39 Add to cart
90 pills - 300 mg
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60 pills - 300 mg
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30 pills - 300 mg
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$165.99 $5.53 No Add to cart
Seroquel 200 mg
180 pills - 200 mg
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$201.95 $3.37 $66.03 Add to cart
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$133.99 $4.47 No Add to cart
Seroquel 100 mg
270 pills - 100 mg
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$315.55 $1.17 $368.36 Add to cart
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$105.93 $1.77 $46.05 Add to cart
30 pills - 100 mg $75.99 $2.53 No Add to cart
Seroquel 50 mg
270 pills - 50 mg
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$210.55 $0.78 $212.36 Add to cart
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60 pills - 50 mg $67.93 $1.13 $26.05 Add to cart
30 pills - 50 mg $46.99 $1.57 No Add to cart
Seroquel 25 mg
360 pills - 25 mg
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$254.55 $0.71 $208.05 Add to cart
180 pills - 25 mg
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90 pills - 25 mg $71.21 $0.79 $44.44 Add to cart
60 pills - 25 mg $55.03 $0.92 $22.07 Add to cart
30 pills - 25 mg $38.55 $1.29 No Add to cart

Product description

Drug Title

Seroquel (Quetiapine)

Pharmacological action

Quetiapine is an atypical antipsychotic that has a higher affinity for serotonin (hydroxytryptamine) receptors (5NT2) than for brain dopamine D1 and D2 receptors. Quetiapine also has greater affinity for histamine and alpha1 adrenoreceptors and less affinity for alpha2 adrenoreceptors. Quetiapine has no detectable affinity for muscarinic and benzodiazepine receptors. Quetiapine exhibits antipsychotic activity in standard tests.


Pharmacokinetics

When administered orally, quetiapine is well absorbed from the gastrointestinal tract and is actively metabolized in the liver. The major plasma metabolites have no marked pharmacological activity.


Food intake does not significantly affect the bioavailability of quetiapine. T1/2 is about 7 hours. About 83% of quetiapine is bound to plasma proteins.


Quetiapine pharmacokinetics is linear, there are no differences in pharmacokinetics between men and women.


Mean clearance of quetiapine in elderly patients is 30-50% less than in patients aged 18 to 65 years.


Mean plasma clearance of quetiapine is approximately 25% lower in patients with severe renal impairment (creatinine clearance less than 30 mL/min/1.73 m2) and in patients with liver damage, but interindividual clearance rates are within limits consistent with healthy volunteers. Approximately 73% of quetiapine is excreted in the urine and 21% in the feces. Less than 5% of quetiapine is not metabolized and is excreted unchanged by the kidneys or in the feces. CYP3A4 has been found to be a key isoenzyme of cytochrome P450-mediated metabolism of quetiapine.


In a study of the pharmacokinetics of quetiapine at various doses, administration of quetiapine prior to ketoconazole or simultaneously with ketoconazole resulted in an average increase in Cmax and area under the concentration-time curve (AUC) of quetiapine of 235% and 522%, respectively, and a decrease in quetiapine clearance of, on average, 84%. The T1/2 of quetiapine increased, but the Tmax was unchanged.


Quetiapine and some of its metabolites have weak inhibitory activity against cytochrome Р450 isoenzymes 1A2, 2С9, 2С19, 2D6 and ZA4, but only at concentrations 10-50 times higher than concentrations observed at the commonly used effective dose of 300-450 mg/day.


Based on in vitro results, concomitant use of quetiapine with other drugs should not be expected to result in clinically significant inhibition of cytochrome P450-mediated metabolism of other drugs.

Contraindications to use

  • Hypersensitivity to any of the drug components;
  • concomitant use with CYP3A4 inhibitors, such as HIV protease inhibitors, azole antifungal drugs, erythromycin, clarithromycin, nefazodone;
  • Children under 18 years of age;
  • period of lactation.


Use with caution in patients with cardiovascular and cerebrovascular diseases or other conditions predisposing to arterial hypotension; the elderly; hepatic insufficiency; history of seizures; pregnancy.


Administration during pregnancy and lactation

It is used with caution during pregnancy. It is contraindicated during lactation.

Administration in liver dysfunction

It is recommended to start therapy with quetiapine from 25 mg/day in patients with hepatic impairment. It is recommended to increase the dose daily by 25-50 mg until an effective dose is reached.

Use in renal impairment

In patients with renal insufficiency, it is recommended to start therapy with quetiapine from 25 mg/day. It is recommended to increase the dose daily by 25-50 mg until an effective dose is achieved.

Administration in children

Contraindicated in children and adolescents under 18 years of age.

Administration in elderly patients

In elderly patients, the starting dose of quetiapine is 25 mg/day. The dose should be increased daily by 25-50 mg until an effective dose is achieved, which is likely to be lower than in younger patients.

Indications for the drug Quetiapine

  • Acute and chronic psychoses, including schizophrenia;
  • Manic episodes in the structure of bipolar disorder.

Dosage regimen

Adults:


Acute and chronic psychoses, including schizophrenia


The daily dose for the first 4 days of therapy is: Day 1 - 50 mg, Day 2 - 100 mg, Day 3 - 200 mg, Day 4 - 300 mg. Starting on day 4, the dose should be adjusted to a clinically effective dose, which is usually between 300 and 450 mg/day. Depending on clinical effect and individual tolerance, the dose may range from 150 to 750 mg/day.


Treatment of manic episodes in the structure of bipolar disorder


Quetiapine is used as monotherapy or as adjuvant therapy for mood stabilization.


The daily dose for the first 4 days of therapy is: Day 1 - 100 mg, Day 2 - 200 mg, Day 3 - 300 mg, Day 4 - 400 mg. By the 6th day of therapy, the daily dose can be increased to 800 mg. Increase in daily dose should not exceed 200 mg per day.


Depending on clinical effect and individual tolerance, the dose may vary from 200 to 800 mg/day. Usually the effective dose is between 400 and 800 mg/day.


For treatment of schizophrenia, the maximum recommended daily dose of quetiapine is 750 mg; for treatment of manic episodes in the structure of bipolar disorder, the maximum recommended daily dose of quetiapine is 800 mg/day.


In elderly patients, the starting dose of quetiapine is 25 mg/day. The dose should be increased daily by 25-50 mg until an effective dose is achieved, which is likely to be lower than in younger patients.


In patients with renal or hepatic impairment, it is recommended that quetiapine therapy be started at 25 mg/day. It is recommended to increase the dose daily by 25-50 mg until an effective dose is achieved.