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Rulide

Rulide
Rulide is used to treat infections in different parts of the body caused by bacteria.

Brand: Roxithromycin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: February 2024
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Package Price Per pill Save Order
Rulide 300 mg
90 pills - 300 mg $79.99 $0.89 $72.56 Add to cart
60 pills - 300 mg $55.55 $0.93 $46.15 Add to cart
30 pills - 300 mg $35.95 $1.20 $14.90 Add to cart
10 pills - 300 mg $16.95 $1.70 No Add to cart
Rulide 150 mg
90 pills - 150 mg $68.95 $0.77 $47.60 Add to cart
60 pills - 150 mg $49.93 $0.83 $27.77 Add to cart
30 pills - 150 mg $27.99 $0.93 $10.86 Add to cart
10 pills - 150 mg $12.95 $1.30 No Add to cart

Product description

Drug Title

Rulide (Roxithromycin)

Pharmacological action

Semi-synthetic oral macrolide antibiotic. The drug is usually sensitive to: Bordetella pertussis; Borrelia burgdorferi; Moraxella ( Branhamella ) catarrhalis; Campylobacter coli, Campylobacter jejuni, Chlamydia trachomatis, psittaci and pneumoniae, Clostridium spp. (including Clostridium perfringens) ; Corynebacterium diptheriae; Enterococcus spp, Gardnerella vaginalis; Methi - S - Staphylococcus; Neisseria meningitidis; Helicobacter pylori; Legionella pneumophilia, Lysteria monocytogenes obiluncus; Mycoplasma pneumoniae; Pasteurella multocida; Peptostreptococcus spp, Porphyromonas spp., Propionibacterium acnes; Rhodococcus equi, Streptococcus pneumoniae, Streptococcus spp.


Haemophilus influenzae, Ureaplasma urealyticum, Vibrio cholerae are moderately sensitive to the drug.


The following are resistant to the drug: Acinetobacter spp, Bacteroides fragilis; Enterobacteriaceae; Methi-R Staphylococcus; Pseudomonas spp; Fusobacterium; Mycoplasma hominis, Nocardia.


Pharmacokinetics

In adults


Roxithromycin is quickly absorbed after oral administration. Roxytromycin is more stable than other macrolides in the acidic environment of the stomach. Taking the drug 15 min before a meal does not affect the pharmacokinetics. After 150 mg usage Cmax in blood is on average 6.6 mg/l and is reached after 2.2 hours. 12 hours intermittent usage provides keeping of effective concentrations in blood during 24 hours. T1/2 after a single dose of 150 mg is 10.5 hours.


After a single dose of 300 mg of roxithromycin an average Cmax in the blood is 9.7 mg/l and is reached after 1.5 hours.


When re-administration of roxithromycin (150 mg 2 times per day, for 10 days) the equilibrium state in plasma is reached between 2-4 days, the Cmax is 9.3 mg/l.


Administration of 300 mg of roxithromycin every 24 h for 11 days provided a Cmax of 10.9 mg/L.


Roxithromycin penetrates well into many tissues, especially into the lungs, palatine tonsils and prostate. The drug also penetrates well into cells, especially neutrophil leukocytes and monocytes, stimulating their phagocytic activity.


Binding to blood proteins is 96%, is saturable and decreases at concentrations of roxithromycin over 4 mg/l.


Roxithromycin is metabolized only partially, more than half of the active substance is excreted unchanged mainly with the feces and urine. In adults with normal renal and hepatic function 65% of roxithromycin is excreted with the feces.


When renal failure the excretion of roxithromycin and its metabolites through the kidneys is approximately 10% of the accepted dose. The dose of the drug does not change in renal failure.


In severe hepatic insufficiency T1/2 is prolonged (25 h) and Cmax is increased.


Less than 0.05% of the administered dose of roxithromycin penetrates into breast milk.



Contraindications to use

  • Concomitant use of ergotamine and dihydroergotamine;
  • Hypersensitivity to macrolides.

Concomitant use with ergotamine derivatives and ergotamine-like vasoconstrictors is not allowed, since it may lead to the development of "ergotism" and necrosis of limb tissues.


Use with caution in patients with severe hepatic insufficiency.


Administration during pregnancy and lactation

Roxithromycin is contraindicated in pregnancy. Small amount of Roxithromycin penetrates into the breast milk, therefore it is necessary to stop breast-feeding or taking the drug.


Administration in liver dysfunction

It is prescribed as a single dose in patients with hepatic impairment.

Administration in renal impairment

In patients with renal failure roxithromycin is prescribed in a dose of 150 mg 2 times per day.

Administration in children

In children (body weight over 40 kg) 150 mg of roxithromycin orally administered at 12-hour intervals. Daily dose is 300 mg.

Administration in elderly patients

The dosage and daily dose of roxithromycin do not vary in elderly patients.

Indications of the drug Rulid

  • Upper respiratory tract infections: acute pharyngitis, tonsillitis, sinusitis;
  • lower respiratory tract infections: pneumonia (including those caused by atypical pathogens such as Chlamydia psittaci, Chlamydia pneumonia, Moraxella (Branhamella) catarrhalis, Legionella pneumophilia, etc.), bronchitis, bacterial infections in chronic obstructive pulmonary diseases;
  • Skin and soft tissue infections;
  • Genital infections (except gonorrhea), including urethritis, cervico-vaginitis;
  • Infections in odontology.


Dosage regimen

Adults are prescribed 150 mg of roxithromycin orally at 12-hour intervals. The daily dose is 300 mg. It is possible to prescribe 300 mg once daily.


Children (body weight over 40 kg) are prescribed 150 mg of roxithromycin orally at 12-hour intervals. The daily dose is 300 mg.


This dosage form is not used in children under 4 years of age!


The dosage and daily dose of roxithromycin do not change in elderly patients.


If there is renal failure, roxithromycin is prescribed in a dose of 150 mg 2 times a day.


In patients with hepatic failure 150 mg is prescribed once.


The duration of roxithromycin dosage depends on the indication for use, the severity of the infection and the activity of the pathogen.


Roxithromycin is taken before meals orally 1 or 2 times / day.


The tablet should be swallowed with enough water.