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Roxithromycin

Roxithromycin
Roxythromycin is an antibiotic that is used to cure infections like Acute pharyngitis (sore throat and discomfort when swallowing), Tonsillitis, Sinusitis, Acute Bronchitis and skin infections caused by several susceptible bacteria.

Brand: Roxithromycin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Roxithromycin 300 mg
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Roxithromycin 150 mg
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30 pills - 150 mg $37.55 $1.25 No Add to cart

Product description

Drug Title

Roxithromycin

Pharmacological action

Semi-synthetic antibiotic of macrolide group, which has a wide range of antibacterial activity. It has a bacteriostatic effect: it binds with 50S subunit of ribosomes, inhibits translocation and transpeptidation reactions, formation of peptide bonds between amino acids and peptide chain, inhibits protein synthesis by ribosomes, and as a result inhibits bacterial growth and reproduction. Good penetration into the cell ensures the effectiveness of roxithromycin against intracellular pathogens (including Chlamydia trachomatis, Chlamydia pneumoniae, Ureaplasma urealyticum, Legionella pneumophila, Mycoplasma pneumoniae).


In vitro to the drug are sensitive: Streptococcus agalactiae, Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes, Mycoplasma pneumoniae, Chlamydiat rachomatis, Chlamydia psittaci, Ureaplasma urealyticum, Legionella pneumophila, Helicobacter pylori, Gardnerella vaginalis, Bordetella pertussis, Moraxella catarrhalis, Haemophilus ducreyi. The following microorganisms showed variable sensitivity in vitro: Streptococcus pyogenes (group A beta-haemolytic streptococcus), Staphylococcus aureus, Haemophilus influenzae, Staphylococcus epidermidis.


Roxytromycin is also effective against anaerobic microorganisms: Bacleroides oralis, Bacteroides melaninogenicus, Bacteroides urealiticus; Clostridium perfringens; Eubacterium spp., Peptococcus spp., Peptostreptococcus spp., Propionibactenum acnes; Rickettsia rickettsii, Rickettsia conorii.


Bacleroides fragilis, Clostridium difficile, Pseudomonas spp. are resistant to the drug; Acinetobacter spp. family Enterobacteriaceae.


Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract after oral administration. Roxytromycin is stable in acidic environment of the stomach; absorption is not influenced by food within 15 minutes after taking the tablet. Cmax after oral administration of 150 mg is 6.6 mg/l, time to maximum concentration (ТСmax) is 2.2 hours, after administration of 300 mg/l and 1.5 hours, respectively. In children, Cmax (in 2-times administration of 2.5 mg/kg/day) is 8.7-10.1 mg/l and is reached after 2 h. Administration at 12-hour intervals ensures maintenance of effective blood concentrations for 24 hours. The equilibrium plasma concentration (Css), when administered 150 mg 2 times daily for 10 days, is reached after 2-4 days and is 9.3 mg/l; when administered 300 mg once daily for 11 days, it is 10.9 mg/l. Blood plasma protein binding is 96%. It is characterized by high tissue penetration, especially in the lungs, palatine tonsils and prostate. Roxytromycin also penetrates well into cells (macrophages) and body fluids. It practically does not penetrate through the blood-brain barrier. Roxithromycin is excreted in small amounts in breast milk. The volume of distribution is 31.2 liters.


It is partially metabolized in the liver, the largest part (more than 50% of the active substance) is excreted unchanged in the intestine, about 12% is excreted by the kidneys and about 15% - by the lungs. The elimination half-life of roxithromycin after a single dose of 150 mg is on average 12 hours.


T1/2 and Cmax are increased in liver function impairment.

Contraindications to use

  • Hypersensitivity to roxithromycin, other macrolides or other components of the drug;
  • pregnancy;
  • lactation;
  • porphyria;
  • concomitant use of vasoconstrictor ergot alkaloids (ergotamine and dihydroergotamine);
  • concomitant use of cisapride, pimozide, astemizole and terfenadine;
  • children under 12 years of age or body weight less than 40 kg (for this dosage form).


With caution: Patients with hepatic impairment; patients with renal impairment, patients over 65 years of age; patients with congenital prolongation of the QT interval, with conditions contributing to cardiac rhythm disturbances (uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia) and in patients receiving class IA and III antiarrhythmic drugs in myasthenia gravis; when concomitantly administered with warfarin, disopyramide, digoxin, colchicine, dopamine receptor agonists - ergot alkaloids (including bromocriptine). including bromocriptine, cabergoline, lisuride, pergolide), cyclosporine, theophylline.


Use during pregnancy and lactation

Roxithromycin is contraindicated in pregnancy.


Roxytromycin penetrates into breast milk in small amounts. If it is necessary to apply the drug during lactation it is necessary to decide on stopping breast-feeding.


Administration if liver function abnormalities

Caution should be exercised when using in patients with hepatic impairment.

Administration in patients with impaired renal function

Caution should be exercised when using in patients with impaired renal function.


Administration in children

This drug is contraindicated in children under 12 years of age or when body weight is less than 40 kg (for this dosage form).

Administration in elderly patients

Caution should be exercised when using the drug in patients over 65 years of age.

Indications of the drug Roxytromycin

Infections of mild to moderate severity caused by pathogens sensitive to roxithromycin:


In adults


  • Upper respiratory tract infections: pharyngitis, tonsillitis, acute sinusitis;
  • Lower respiratory tract infections: pneumonia (including pneumonia caused by "atypical" pathogens, including Chlamydia psittaci, Chlamydia pneumoniae, Moraxella catarrhalis, Legionella pneumophila), bronchitis;
  • skin and soft tissue infections;
  • urinary tract infections caused by Chlamydia trachomatis and Ureaplasma urealyticum;
  • Infections in odontology, infections of the oral cavity and teeth.

In children.


  • Upper respiratory tract infections: tonsillitis, pharyngitis, acute sinusitis;
  • Lower respiratory tract infections: pneumonia (including pneumonia caused by "atypical" pathogens, including Chlamydia psittaci, Chlamydia pneumoniae, Moraxella catarrhalis, Legionella pneumophila), bronchitis;
  • skin and soft tissue infections.

Dosing regimen

Orally. The drug should be taken before meals with plenty of fluids.


Adults and children over 12 years of age (body weight over 40 kg): The standard dose is 150 mg twice a day, 12 hours apart, or 300 mg once (adults only).


In elderly patients


In elderly patients the single and daily dose of roxithromycin does not change.


In patients with renal failure


In patients with renal failure roxithromycin is prescribed in a dose of 150 mg twice a day.


In patients with severe hepatic impairment


In patients with severe hepatic insufficiency (e.g., in cirrhosis with jaundice or ascites) the dose should be reduced by 2 times, that is, 150 mg of roxithromycin once a day.


Treatment duration


The duration of roxithromycin depends on the indication for use, the microorganism that caused the infection and the severity of the infectious process. In adults, the usual duration of treatment is 5-10 days; for infections caused by beta-haemolytic streptococcus, the course of treatment should be at least 10 days. In children, the usual duration of treatment course is 5-10 days; in infections caused by beta-haemolytic streptococcus, the course of treatment should be at least 10 days. The duration of therapy should not exceed 10 days.