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The drug is used as part of adjuvant therapy in the treatment of alcoholism and drug dependence in adults. The drug prescribed by a doctor can also be used to treat other conditions.

Brand: Naltrexone

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
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Product description


Revia (Naltrexone)

Pharmacological action

Competitive opioid receptor antagonist. Eliminates central and peripheral effects of opioids, including endogenous endorphins. Its effect is more intense and long lasting than that of naloxone.

In alcoholism it binds to opioid receptors and blocks the effects of endorphins. Reduces the need for alcohol and prevents relapse.

Prolonged use of naltrexone does not cause tolerance or dependence.


After oral administration, Revia (Naltrexone) is almost completely absorbed from the gastrointestinal tract. Cmax of naltrexone and its active metabolite 6-β-naltrexol in blood plasma is reached after 1 hour.

With long-term use naltrexone does not cumulate in the body, while the plasma concentration of 6-β-naltrexol reaches 40%. This is because the T1/2 of the metabolite is greater than that of naltrexone.

95% of the naltrexone dose is biotransformed in the liver into pharmacologically active metabolites, the main one being 6-β-naltrexol, which is also an opioid antagonist. The second metabolite is 2-hydroxy-3-methoxy-6-β-naltrexol. Revia (Naltrexone) and its metabolites undergo intrahepatic recirculation.

Revia (Naltrexone) and its metabolites are excreted mainly by the kidneys. The amount of free naltrexone excreted in the urine is less than 1%, and the amount of free and bound 6-β-naltrexone is approximately 38%. The average T1/2 of naltrexone is 4 h, 6-β-naltrexol 13 h.

Contraindications to use

Hypersensitivity to naltrexone; patients taking opioid analgesics, including patients with current physical opioid dependence; patients in acute opioid withdrawal (opioid withdrawal syndrome); patients who have not undergone naloxone provocation test or have a positive result of urine opioid test; severe liver function disorders (including acute hepatitis and liver failure); pregnancy, lactation (breastfeeding) period; children and adolescents under 18 years.

With caution: liver and/or kidney function disorders.

Administration during pregnancy and lactation

Contraindicated for use during pregnancy and lactation (breast-feeding).

Administration if liver function abnormalities

Contraindicated in acute hepatitis, liver failure. It is used with caution in patients with liver dysfunction.

Administration in patients with impaired renal function

It is used with caution in patients with impaired renal function.

Administration in children

Administration in children and juveniles under 18 years old is contraindicated.

Administration in elderly patients

Caution should be exercised when used in elderly patients.

Indications of active substances of Revia (Naltrexone)

Treatment of alcohol addiction (as part of combined therapy) and blockade of effects of exogenously injected opioids; complex therapy of opioid addiction in order to maintain the patient in a state when opioids cannot exert their characteristic action; for prevention of relapse of opioid addiction after opioid detoxification.

Dosing regimen

You should strictly follow the compliance of the dosage form used for a particular drug indications for use and the dosing regimen.

It is used orally and v/m. The dose, regimen and duration of treatment shall be determined individually, depending on the indications, clinical situation and the dosage form used.