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Ranitidine

Ranitidine
Ranitidine is used for the treatment of certain conditions, when the stomach emits too much acid (e.g. Zollinger-Ellison syndrome). It can also be used to treat intestinal ulcers that did not respond the other kinds of treatment.

Brand: Ranitidine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: April 2024
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Ranitidine 300 mg
360 pills - 300 mg
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$133.99 $0.37 $81.71 Add to cart
270 pills - 300 mg
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180 pills - 300 mg $75.95 $0.42 $31.90 Add to cart
120 pills - 300 mg $55.87 $0.47 $16.03 Add to cart
90 pills - 300 mg $45.73 $0.51 $8.20 Add to cart
60 pills - 300 mg $35.95 $0.60 No Add to cart
Ranitidine 150 mg
360 pills - 150 mg
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$108.99 $0.30 $84.27 Add to cart
270 pills - 150 mg $85.89 $0.32 $59.06 Add to cart
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60 pills - 150 mg $32.21 $0.54 No Add to cart

Product description

Drug Name

Ranitidine

Pharmacological action

Ranitidine blocks histamine H2-receptors of parietal cells of gastric mucosa, decreases basal and stimulated secretion of hydrochloric acid, caused by irritation of baroreceptors, food load, action of hormones and biogenic stimulators (gastrin, histamine, pentagastrin). Ranitidine reduces the volume of gastric juice and the content of hydrochloric acid in it, increases pH of the stomach contents, which leads to decrease in pepsin activity. After oral administration in therapeutic doses does not affect the level of prolactin. It inhibits microsomal enzymes.


Duration of action after single administration is up to 12 hours.


Pharmacokinetics 

It is rapidly absorbed; the degree of absorption is not affected by food intake. Bioavailability of ranitidine is about 50% when administered orally. Cmax in plasma is reached 2-3 hours after intake.


Binding to plasma proteins does not exceed 15%. It is slightly metabolized in the liver with the formation of desmethylranitidine and S-oxide of ranitidine.


It has the effect of first passage through the liver. The rate and extent of elimination are little dependent on the liver condition.


T1/2 after oral intake is 2.5 hours, at an IQ of 20-30 ml/min it is 8-9 hours. It is eliminated mainly in the urine (60-70%, 35% unchanged), a small amount is excreted in the faeces. It penetrates poorly through the blood-brain barrier. It penetrates through the placenta. It is excreted with breast milk (concentration in breast milk in women during lactation is higher than in plasma).


Contraindications to use

  • pregnancy;
  • lactation;
  • Children under 12 years of age;
  • Hypersensitivity to ranitidine or other components of the drug.

Caution - renal and/or hepatic failure, liver cirrhosis with portosystemic encephalopathy in anamnesis, acute porphyria (including anamnesis).


Administration in liver dysfunction

In presence of concomitant liver dysfunction, the dose may require reduction.

Administration in renal impairment

Recommended dose is 150 mg/day for patients with renal insufficiency with CKD less than 50 ml/min.

Administration in children

Contraindication: Children under 12 years of age.

Indications of the drug Ranitidine

  • Treatment and prevention of exacerbations of gastric and duodenal ulcers;
  • Gastric and duodenal ulcers associated with taking NSAIDs;
  • reflux esophagitis, erosive esophagitis;
  • Zollinger-Ellson syndrome;
  • Treatment and prevention of postoperative, "stress" ulcers of the upper gastrointestinal tract;
  • Prevention of recurrent bleeding from the upper gastrointestinal tract;
  • prevention of aspiration of gastric juice during surgeries under general anesthesia (Mendelsohn syndrome).

Dosing regimen

Ranitidine is taken independently of meals, without chewing, with a small amount of liquid.


Adults and children over 12 years of age:


Peptic ulcer disease of the stomach and 12 duodenum. For treatment of exacerbations 150 mg 2 times per day (in the morning and in the evening) or 300 mg at night. If necessary, 300 mg 2 times per day. The course of treatment is 4 to 8 weeks. For prevention of exacerbations, 150 mg at night is prescribed, for smoking patients - 300 mg at night.


Ulcers associated with taking NSAIDs. It is prescribed 150 mg twice a day or 300 mg at night for 8-12 weeks. Prevention of ulcer formation when taking NSAIDs - 150 mg 2 times per day.


Postoperative and "stress" ulcers. It is prescribed in 150 mg 2 times per day for 4-8 weeks.


Erosive reflux esophagitis. It is prescribed 150 mg 2 times a day or 300 mg at night. If necessary, the dose can be increased to 150 mg 4 times a day. The course of treatment is 8-12 weeks. Prolonged prophylactic therapy is 150 mg 2 times per day.


Zollinger-Ellison syndrome. The initial dose is 150 mg 3 times/day; if necessary, the dose may be increased.


Prevention of recurrent bleeding. 150 mg 2 times per day.


Prevention of Mendelsohn syndrome. It is administered in a dose of 150 mg 2 hours before anesthesia and preferably 150 mg the night before.


In the presence of concomitant hepatic dysfunction, a dose reduction may be required.


In patients with renal impairment with a CKR less than 50 ml/min, the recommended dose is 150 mg/day.