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Protonix

Protonix
Protonix is a proton pump inhibitor which is prescribed for the treatment of severe inflammation and erosive esophagitis which is caused due to GERD (gastroesophageal reflux disease).

Brand: Pantoprazole

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Package Price Per pill Save Order
Protonix 40 mg
360 pills - 40 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$219.99 $0.61 $163.89 Add to cart
270 pills - 40 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$171.53 $0.64 $116.38 Add to cart
180 pills - 40 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$121.98 $0.68 $69.96 Add to cart
120 pills - 40 mg $89.97 $0.75 $37.99 Add to cart
90 pills - 40 mg $73.91 $0.82 $22.06 Add to cart
60 pills - 40 mg $53.95 $0.90 $10.03 Add to cart
30 pills - 40 mg $31.99 $1.07 No Add to cart
Protonix 20 mg
360 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$135.99 $0.38 $151.89 Add to cart
270 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$106.95 $0.40 $108.96 Add to cart
180 pills - 20 mg $77.99 $0.43 $65.95 Add to cart
120 pills - 20 mg $56.99 $0.47 $38.97 Add to cart
90 pills - 20 mg $46.99 $0.52 $24.98 Add to cart
60 pills - 20 mg $36.99 $0.62 $10.99 Add to cart
30 pills - 20 mg $23.99 $0.80 No Add to cart

Product description

DRUG TITLE

Protonix (Pantoprazole)

Pharmacological action

H+-K+-ATPase inhibitor. It blocks final stage of hydrochloric acid secretion, reduces the level of basal and stimulated (regardless of the type of stimulus) hydrochloric acid secretion in the stomach. In duodenal ulcer associated with Helicobacter pylori, this decrease in gastric secretion increases the sensitivity of the micro-organism to antibiotics. Protonix (Pantoprazole) has intrinsic antimicrobial activity against Helicobacter pylori.

Pharmacokinetics

Pantoprazole is rapidly absorbed after oral administration. Cmax after the first dose of 20 mg is about 1.0-1.5 mcg/ml.


The pharmacokinetics of pantoprazole are the same after single and multiple doses. In the dose range of 10-80 mg, the pharmacokinetics of pantoprazole in plasma remains linear with both oral and intravenous administration.


The absolute bioavailability of pantoprazole when taken orally is about 77%. Binding to plasma proteins is 98%. Vd is 0.15 l/kg.


It is metabolized mainly in the liver. The main metabolic pathway is demethylation by CYP2C19 followed by sulfate conjugation. Other metabolic pathways include oxidation by CYP3A4.


The final T1/2 is approximately 1 h and clearance is approximately 0.1 L/h/kg.


The main route of excretion is through the kidneys (about 80%) as pantoprazole metabolites, the rest is excreted in the feces.



Contraindications to use

Hypersensitivity to pantoprazole; dyspepsia of neurotic genesis, malignant gastrointestinal diseases, severe liver failure; pregnancy, lactation (breast-feeding); childhood age; taking HIV protease inhibitors, such as atazanavir and nelfinavir, which absorption depends on pH of gastric juice (for oral administration).


Caution: hepatic insufficiency.


Administration during pregnancy and lactation

Contraindicated for use during pregnancy and lactation (breast-feeding).


If it is necessary to apply during lactation, it is necessary to decide whether or not to stop breastfeeding.


Administration in patients with liver dysfunction

It is contraindicated in patients with severe hepatic impairment. When used in patients with hepatic impairment, the plasma liver enzymes should be monitored regularly and in case of their increase, pantoprazole should be stopped.

Administration in renal impairment

It is not recommended to exceed the dose of 40 mg/day in patients with impaired renal function.

Administration in children

Contraindications for use in children and adolescents under 18 years of age.


Administration in elderly patients

Proton pump inhibitors, especially when used in high doses and for a long time (more than 1 year), may modestly increase the risk of hip, carpal and spine fractures mainly in elderly patients. In elderly patients, it is not recommended to exceed the dose of 40 mg/day.

Indications of active substances of Pantoprazole

Gastric and duodenal ulcer in acute phase, erosive gastritis (incl. associated with taking NSAIDs), stress ulcers and their complications (bleeding, perforation, penetration); Zollinger-Ellison syndrome; eradication of Helicobacter pylori (in combination with antibacterial therapy); gastroesophageal reflux disease; erosive reflux esophagitis.

Dosing regimen

 You should strictly follow the compliance of the dosage form used for the specific drug indications and the dosing regimen.

It is used orally and intravenously. The dose, method and route of administration, duration of therapy shall be determined individually, depending on the indications, clinical situation and the dosage form used.