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Procardia

Procardia
Procardia is a calcium channel blocker that is used for the treatment of angina (chest pain). It reduces and blocks the effect of normal calcium on blood vessel constriction and thereby helps it to relax and widens it.

Brand: Nifedipine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Procardia 30 mg
270 pills - 30 mg
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$222.93 $0.83 $118.98 Add to cart
180 pills - 30 mg
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$153.99 $0.86 $73.95 Add to cart
120 pills - 30 mg
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90 pills - 30 mg $84.93 $0.94 $29.04 Add to cart
60 pills - 30 mg $61.55 $1.03 $14.43 Add to cart
30 pills - 30 mg $37.99 $1.27 No Add to cart

Product description

Drug Title

Procardia (Nifedipine)

Pharmacological action

Selective class II calcium channel blocker, dihydropyridine derivative. Inhibits calcium influx into cardiomyocytes and vascular smooth muscle cells. It has antianginal and hypotensive effects. Reduces the tone of vascular smooth muscle. Dilates coronary and peripheral arteries, reduces myocardial pressure, BP and slightly myocardial contractility, reduces postload and myocardial oxygen demand. It improves coronary blood flow. It has almost no antiarrhythmic activity. It does not inhibit myocardial conduction.


Pharmacokinetics

When administered orally, it is quickly absorbed from the gastrointestinal tract. It is metabolized during "first passage" through the liver. Protein binding is 92-98%. It is metabolized in liver to form inactive metabolites. T1/2 is about 2 hours. It is excreted mainly by the kidneys as metabolites and in trace amounts unchanged; 20% is excreted through the intestine as metabolites.

Contraindications to use

Arterial hypotension (systolic BP below 90 mmHg), collapse, cardiogenic shock, severe heart failure, severe aortic stenosis; hypersensitivity to nifedipine.


Use in pregnancy and lactation

Adequate and strictly controlled safety studies of nifedipine in pregnancy have not been conducted. The use of nifedipine in pregnancy is not recommended.


As nifedipine is excreted with breast milk, its use during lactation should be avoided or breastfeeding should be stopped during treatment.


Embryotoxic, fetotoxic and teratogenic effects of nifedipine have been found in experimental studies.


Application in liver dysfunction

Nifedipine should be used only in case of liver dysfunction in the clinic under strict medical supervision. High doses of nifedipine should be avoided in patients with hepatic impairment.


Administration in renal impairment

In patients with impaired renal function, nifedipine should be used only in clinic under close medical supervision. High doses of nifedipine should be avoided in patients with impaired renal function.


Use in elderly patients

In elderly patients, cerebral blood flow is more likely to decrease due to acute peripheral vasodilation.

Indications of active substances of the drug Procardia (Nifedipine)

Prevention of angina attacks (including vasospastic angina), in some cases - relief of angina attacks; arterial hypertension, hypertensive crises; Raynaud's disease.


Dosing regimen

Individual. For oral administration the initial dose is 10 mg 3-4 times per day. If necessary, the dose is gradually increased to 20 mg 3-4 times per day. In special cases (variant angina pectoris, severe arterial hypertension) the dose may be increased to 30 mg 3-4 times per day for short periods. Sublingual doses of 10-20 mg (rarely 30 mg) may be used to relieve a hypertensive crisis or an attack of angina pectoris.


Intravenously to stop an attack of angina pectoris or hypertensive crisis, 5 mg for 4-8 hours.


Intracoronary for treatment of acute coronary artery spasms, a bolus of 100-200 mcg is administered. In stenosis of large coronary vessels, the initial dose is 50-100 mcg.


Maximum daily doses: when administered orally - 120 mg, when administered intravenously - 30 mg.