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Prilosec is a used in the treatment of diseases like GERD, Zollinger Ellison Syndrome and dyspepsia. It is a proton pump inhibitor which reduces the amount of acid produced in the stomach.

Brand: Omeprazole

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Prilosec 40 mg
360 pills - 40 mg
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$355.99 $0.99 $279.89 Add to cart
270 pills - 40 mg
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180 pills - 40 mg
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120 pills - 40 mg
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60 pills - 40 mg $82.11 $1.37 $23.87 Add to cart
30 pills - 40 mg $52.99 $1.77 No Add to cart
Prilosec 20 mg
270 pills - 20 mg
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$155.95 $0.58 $140.60 Add to cart
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90 pills - 20 mg $63.93 $0.71 $34.92 Add to cart
60 pills - 20 mg $49.97 $0.83 $15.93 Add to cart
30 pills - 20 mg $32.95 $1.10 No Add to cart
Prilosec 10 mg
360 pills - 10 mg
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$153.99 $0.43 $157.89 Add to cart
270 pills - 10 mg
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90 pills - 10 mg $55.93 $0.62 $22.04 Add to cart
60 pills - 10 mg $41.94 $0.70 $10.04 Add to cart
30 pills - 10 mg $25.99 $0.87 No Add to cart

Product description

Drug Title

Prilosec (Omeprazole)

Pharmacological action

Prilosec (Omeprazole) is an anti-ulcer drug, an inhibitor of the enzyme H+/K+-adenosine triphosphate (ATP)-phase. Inhibits H+/K+-adenosine triphosphate (ATP)-phase (H+/K+-adenosine triphosphate (ATP)-phase, aka "proton pump" or "proton pump") activity in parietal cells of the stomach, thus blocking transport of hydrogen ions and the final stage of hydrochloric acid synthesis in the stomach. Prilosec (Omeprazole) is a prodrug. In the acidic environment of the parietal cell tubules, omeprazole converts to the active metabolite sulfenamide, which inhibits the membrane H+/K+-adenosine triphosphate (ATP)-phase by binding to it via a disulfide bridge. This explains the high selectivity of omeprazole action on parietal cells, where there is a medium for sulfenamide formation. Biotransformation of omeprazole to sulfenamide occurs rapidly (in 2-4 minutes). Sulfenamide is cationic and is not absorbed.

Prilosec (Omeprazole) suppresses basal and stimulated by any irritant hydrochloric acid secretion in the final stage. It reduces total gastric secretion and inhibits pepsin secretion. Omeprazole has been found to have gastroprotective activity, the mechanism of which is not clear. It has no effect on the production of intrinsic factor Kahl and on the rate of transfer of food mass from the stomach to the duodenum. Omeprazole has no effect on acetylcholine and histamine receptors.

Prilosec (Omeprazole) capsules contain coated microgranules, gradual release and onset of action of omeprazole begins 1 hour after intake, reaches a maximum after 2 hours, persists for 24 hours or more. Inhibition of 50% of maximum secretion after a single dose of 20 mg of the drug lasts for 24 hours.

A single daily dose provides rapid and effective inhibition of daytime and nighttime gastric secretion, reaching its maximum after 4 days of treatment. In patients with duodenal ulcer disease, administration of 20 mg of omeprazole maintains pH=3 inside the stomach for 17 hours. After discontinuation of the drug secretory activity is fully restored after 3-5 days.


Absorption is high. Bioavailability is 30-40% (almost 100% in case of hepatic insufficiency), it increases in elderly patients and patients with liver dysfunction; renal dysfunction has no effect. TCmax is 0.5-3.5 hours.

Having high lipophilicity, easily penetrates into the parietal cells of the stomach. Binding to plasma proteins is 90-95% (albumin and acidic alpha1-glycoprotein).

T1/2 is 0.5-1 hours (in case of hepatic insufficiency - 3 hours), clearance - 500-600 ml/min. It is almost completely metabolized in liver with participation of CYP2C19 enzyme system, with formation of 6 pharmacologically inactive metabolites (hydroxyomeprazole, sulfide and sulfone derivatives, etc.). It is an inhibitor of CYP2C19 isoenzyme. Excretion by the kidneys (70-80%) and with the bile (20-30%) as metabolites.

In chronic renal insufficiency the excretion decreases in proportion to the decrease in creatine clearance. In elderly patients excretion decreases.

Contraindications to use

  • childhood;
  • pregnancy;
  • lactation;
  • hypersensitivity.

With caution: renal and/or hepatic failure.

Administration during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Administration in patients with liver dysfunction

With caution: hepatic insufficiency. In patients with hepatic insufficiency, 10-20 mg once a day (in case of severe hepatic insufficiency, the daily dose should not exceed 20 mg);

Administration in renal impairment

Caution: renal failure. No dosage adjustment is required in case of renal dysfunction.

Administration in children

Contraindicated in children.

Administration in elderly patients.

Correcting the dosage regimen is not required in elderly patients.

Indications of Prilosec (Omeprazole)

Gastric and duodenal ulcer (in the phase of exacerbation and contradictory treatment), including those associated with Helicobacter pylori (as part of combination therapy);

reflux esophagitis (including erosive).

hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);

Gastropathy caused by taking nonsteroidal anti-inflammatory drugs.

Dosing regimen

Orally, capsules are usually taken in the morning, without chewing, with a small amount of water (just before meals).

In exacerbation of peptic ulcer disease, reflux esophagitis and gastropathy caused by taking NSAIDs - 20 mg once daily. In patients with a severe course of reflux esophagitis, the dose is increased to 40 mg once daily. The course of treatment for duodenal ulcer is 2-4 weeks, if necessary - 4-5 weeks; for gastric ulcer, for reflux esophagitis, for erosive-ulcerous lesions of the GIT caused by taking NSAIDs - for 4-8 weeks.

Reduction of disease symptoms and scarring of ulcers in most cases occurs within 2 weeks. Patients who did not have complete healing of the ulcer after two weeks should continue treatment for 2 more weeks.

Patients who are resistant to treatment with other anti-ulcer drugs are prescribed 40 mg per day. The course of treatment for duodenal ulcer is 4 weeks, for gastric ulcer and reflux esophagitis - 8 weeks.

In Zollinger-Elisson syndrome it is usually 60 mg 1 time per day; if necessary, the dose is increased to 80-120 mg/day (the dose is divided into 2 doses).

For prevention of recurrence of peptic ulcer disease, 10 mg once daily.

For eradication of Helicobacter pylori "triple" therapy is used (for 1 week: omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg 2 times daily; or omeprazole 20 mg, clarithromycin 250 mg, metronidazole 400 mg 2 times daily; or omeprazole 40 mg once daily, amoxicillin 500 mg and metronidazole 400 mg 3 times daily)

or "double" therapy (for 2 weeks: omeprazole 20-40 mg and amoxicillin 750 mg twice daily or omeprazole 40 mg once daily and clarithromycin 500 mg three times daily or amoxicillin 0.75-1.5 g-2 times daily).

In hepatic failure 10-20 mg once daily (in severe hepatic failure daily dose should not exceed 20 mg); in renal impairment and elderly patients dosage regimen adjustment is not required.