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Paroxetine

Paroxetine
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is used to treat depression and Obsessive Compulsive Disorder. In some cases it is also prescribed for the treatment of panic disorder or posttraumatic stress disorder (PTSD).

Brand: Paroxetine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
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Package Price Per pill Save Order
Paroxetine 40 mg
360 pills - 40 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$403.76 $1.12 $204.76 Add to cart
270 pills - 40 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$332.11 $1.23 $124.28 Add to cart
180 pills - 40 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$234.22 $1.30 $70.04 Add to cart
120 pills - 40 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$171.59 $1.43 $31.25 Add to cart
90 pills - 40 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$140.40 $1.56 $11.73 Add to cart
60 pills - 40 mg $96.02 $1.60 $5.40 Add to cart
30 pills - 40 mg $50.71 $1.69 No Add to cart
Paroxetine 30 mg
360 pills - 30 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$363.67 $1.01 $219.65 Add to cart
270 pills - 30 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$302.45 $1.12 $135.04 Add to cart
180 pills - 30 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$219.59 $1.22 $72.07 Add to cart
120 pills - 30 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$158.44 $1.32 $36.00 Add to cart
90 pills - 30 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$127.83 $1.42 $18.00 Add to cart
60 pills - 30 mg $91.20 $1.52 $6.02 Add to cart
30 pills - 30 mg $48.61 $1.62 No Add to cart
Paroxetine 20 mg
360 pills - 20 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$324.77 $0.90 $194.23 Add to cart
270 pills - 20 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$248.25 $0.92 $141.00 Add to cart
180 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$171.76 $0.95 $87.74 Add to cart
120 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$120.79 $1.01 $52.21 Add to cart
90 pills - 20 mg $95.99 $1.07 $33.76 Add to cart
60 pills - 20 mg $69.87 $1.16 $16.63 Add to cart
30 pills - 20 mg $43.25 $1.44 No Add to cart
Paroxetine 10 mg
360 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$265.88 $0.74 $156.28 Add to cart
270 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$202.99 $0.75 $113.63 Add to cart
180 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$140.25 $0.78 $70.83 Add to cart
120 pills - 10 mg $98.28 $0.82 $42.44 Add to cart
90 pills - 10 mg $77.93 $0.87 $27.61 Add to cart
60 pills - 10 mg $56.25 $0.94 $14.11 Add to cart
30 pills - 10 mg $35.18 $1.17 No Add to cart

Product description

Drug Title

Paroxetine

Pharmacological action

Antidepressant, selective serotonin reuptake inhibitor. It has a bicyclic structure different from that of other known antidepressants.


It has antidepressant and anxiolytic effects with a fairly pronounced stimulating (energizing) effect.


Its antidepressant (thymoanaleptic) effect is due to paroxetine's ability to selectively block reuptake of serotonin by presynaptic membranes, which results in increased free content of this neurotransmitter in the synaptic cleft and its increased activity in CNS.


The effect on m-cholinoreceptors, α- and β-adrenoreceptors is insignificant, which determines a very mild severity of the corresponding side effects.


Pharmacokinetics

After oral administration, paroxetine is well absorbed from the gastrointestinal tract. Food intake has no effect on absorption. Css is established by 7-14 days from the start of therapy.


It is metabolized mainly in the liver. The main metabolites of paroxetine are polar and conjugated oxidation and methylation products. Due to the low pharmacological activity of the metabolites, their effect on therapeutic efficacy is unlikely.


T1/2 is on average 16-24 hours. Less than 2% is excreted unchanged with urine, the rest is excreted as metabolites either with urine (64%) or bile.


Excretion of paroxetine is biphasic.


Pharmacokinetic parameters do not change with prolonged continuous administration.

Contraindications to use

Hypersensitivity to paroxetine; concomitant use of MAO inhibitors and up to 14 days after their withdrawal; concomitant use with thioridazine and pimozide; pregnancy; age under 18 years.


With caution: liver failure, renal failure, closed-angle glaucoma, prostatic hyperplasia, mania, cardiac pathology, epilepsy, seizures, use of electropulse therapy; use of drugs and presence of diseases that increase the risk of bleeding; presence of risk factors for increased bleeding; advanced age.


Administration during pregnancy and lactation

It is contraindicated for use during pregnancy. Application during breast-feeding is contraindicated. If it is necessary to apply during lactation, it is necessary to decide on stopping breast-feeding.

Administration in patients with liver dysfunction

Caution should be exercised when using in patients with hepatic impairment.

Administration in patients with impaired renal function

Caution should be exercised when using in patients with impaired renal function.

Administration in children

Contraindications for use in children and adolescents under 18 years of age.


Administration in elderly patients

Caution should be exercised when used in elderly patients.

Indications for the active substances of the drug Paroxetine

Depression of various etiologies, including conditions accompanied by anxiety, obsessive-compulsive disorders, panic disorders, including those with agoraphobia, sociophobia, generalized anxiety disorder, post-traumatic stress disorder.

Dosing regimen

Orally. The dose, regimen and duration of therapy are determined individually, depending on the indication, clinical situation, effectiveness of therapy and age of the patient.