Loading...



Shopping cart processing ...
0
Your cart0
Products 0
Price $0.00
Bestsellers Pill categories
Customer Support 24/7
usa canada USA
uk UK
au AU
Live Chat 24/7
Menu
Customer Support 24/7
USA/Canada Toll Free USA
UK UK
AUS AU
Customer Support 24/7
usacanada USA
uk UK
au AU
We accept
  • Visa
  • MasterCard
  • Amex
  • JCB
Currency
USD
Your cart: $0.00 (0 items)
Checkout

Categories list

Choosing us you get:

  • Reliable supplier
  • Low Internet prices
  • Free bonus pills
  • Discount on all future orders
  • Discreet package
  • SSL secure orders
Worldwide Shipping!

Testimonials:

  • Mike Daniel Hereford, UK
    Thanks today I got my order which I made 9 days ago. Bonus Pills and 10% discount code is attached. Thanks.
More info »

Nootropil

Nootropil
Nootropil improves the delivery of oxygen and glucose to the brain for patients with dementia after several heart attacks.

Brand: Piracetam

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: April 2024
View product image
Package Price Per pill Save Order
Nootropil 1200 mg
360 pills - 1200 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$863.99 $2.40 $158.29 Add to cart
270 pills - 1200 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$655.77 $2.43 $110.94 Add to cart
180 pills - 1200 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$440.39 $2.45 $70.75 Add to cart
120 pills - 1200 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$299.43 $2.50 $41.33 Add to cart
90 pills - 1200 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$229.42 $2.55 $26.15 Add to cart
60 pills - 1200 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$156.01 $2.60 $14.37 Add to cart
30 pills - 1200 mg $85.19 $2.84 No Add to cart
Nootropil 800 mg
360 pills - 800 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$363.55 $1.01 $80.33 Add to cart
270 pills - 800 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$275.91 $1.02 $57.00 Add to cart
180 pills - 800 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$185.95 $1.03 $35.99 Add to cart
120 pills - 800 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$126.99 $1.06 $20.97 Add to cart
90 pills - 800 mg $96.93 $1.08 $14.04 Add to cart
60 pills - 800 mg $66.95 $1.12 $7.03 Add to cart
30 pills - 800 mg $36.99 $1.23 No Add to cart

Product description

DRUG TITLE

Nootropil (Piracetam)

Pharmacological action

Nootropic drug, cyclic derivative of gamma-aminobutyric acid (GABA).


The available data suggest that the main mechanism of action of piracetam is not cell-specific or organ-specific.


Piracetam binds to the polar heads of phospholipids and forms mobile piracetam-phospholipid complexes. As a result, the two-layer structure of the cell membrane and its stability are restored, which in turn leads to restoration of the three-dimensional structure of membrane and transmembrane proteins and restoration of their function.


At the neuronal level, piracetam facilitates various types of synaptic transmission with a predominant effect on the density and activity of postsynaptic receptors (data obtained in animal studies).


Piracetam improves functions such as learning, memory, attention, and consciousness without having sedative or psychostimulant effects.


The hemorheological effects of piracetam are related to its effect on red blood cells, platelets and the vascular wall.


In patients with sickle cell anemia, piracetam increases the ability of red blood cells to deform, reduces blood viscosity and prevents the formation of "coin columns". In addition, it reduces platelet aggregation without significantly affecting their number.


In animal studies, piracetam has been shown to prevent vasospasm and counteract various vasospastic agents.


In studies in healthy volunteers, piracetam reduced erythrocyte adhesion to vascular endothelium and stimulated prostacyclin production by healthy endothelium.


Pharmacokinetics

Absorption .


After oral administration piracetam is quickly and almost completely absorbed from the gastrointestinal tract. After a single dose of 3.2 g, Cmax is 84 µg/ml, after repeated intake of 3.2 mg three times a day - 115 µg/ml and is reached after 1 hour in plasma and after 5 hours in cerebrospinal fluid. Food intake reduces Cmax by 17% and increases Tmax to 1.5 h. In women when receiving piracetam in dose 2.4 g, Cmax and AUC are 30% higher than in men.


Distribution and metabolism


It does not bind with blood plasma proteins.


Vd of piracetam is about 0.6 l/kg.


In animal studies it was found that piracetam selectively accumulates in the cortical tissues, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia.


It is not metabolized in the body.


It penetrates the barrier of the placenta and the electrodermal barrier.


Excretion


T1/2 from blood plasma is 4-5 hours, from cerebrospinal fluid 8.5 hours. T1/2 is independent of the route of administration.


80-100% of piracetam is excreted unchanged by the kidneys through renal filtration. Total clearance of piracetam in healthy volunteers is 80-90 ml/min.


Pharmacokinetics in special clinical cases


T1/2 is prolonged in renal failure; in the terminal stage of chronic renal failure, up to 59 h.


Pharmacokinetics of piracetam does not change in patients with hepatic failure.


It penetrates through the filter membranes of devices for hemodialysis.

Contraindications to use

  • Psychomotor agitation at the time of prescription;
  • Huntington's chorea;
  • acute impairment of cerebral circulation (hemorrhagic stroke);
  • end-stage chronic renal failure (at CKR < 20 ml/min);
  • children under 1 year of age (for oral solution);
  • children under 3 years of age (for the tablets);
  • Hypersensitivity to the drug components;
  • hypersensitivity to pyrrolidone derivatives.

Caution should be exercised when the drug is used in patients with hemostasis disorders, major surgical interventions, severe bleeding, chronic renal failure (CKR 20-80 ml/min).


Administration during pregnancy and lactation

No adequate and well-controlled studies on the safety of Nootropil administration during pregnancy have been conducted. No controlled studies on its use during pregnancy have been conducted.


Piracetam crosses the placental barrier. Concentration of the drug in newborns reaches 70-90% of its concentration in blood of the mother. Nootropil should not be prescribed during pregnancy.


Piracetam is excreted with breast milk. When prescribing the drug during lactation, it is necessary to refrain from breastfeeding.


Administration in patients with liver dysfunction

No dosage adjustment is required in patients with hepatic impairment.


Administration in children

Contraindication: children under 1 year of age (for oral solution); children under 3 years of age (for tablets).


Administration in elderly patients

In elderly patients, the dose is adjusted in case of renal insufficiency; in case of long-term therapy, the renal function control is required.

Indications of the drug Nootropil

Adults


Symptomatic treatment of psycho-organic syndrome, particularly in elderly patients with memory loss, dizziness, decreased concentration and alertness, mood changes, behavioral disorders, and gait disturbances (these symptoms may be early signs of age-related diseases, such as Alzheimer's disease and senile dementia of the Alzheimer type)

treatment of vertigo and related balance disorders, except for vasomotor and psychogenic vertigo;

treatment of cortical myoclonias (as monotherapy or as part of complex therapy);

prevention of sickle cell vaso-occlusive crisis.

Children


  • Treatment of dyslexia (as part of complex therapy);
  • prophylaxis of sickle cell vaso-occlusive crisis.


Dosing regimen

The drug is administered orally, with meals or on an empty stomach, with fluids.


Symptomatic treatment of psychoorganic syndrome: 2.4-4.8 g/day in 2-3 doses.


Treatment of dizziness and associated balance disorder: 2.4-4.8 g/d in 2-3 doses.


Treatment of cortical myoclonus begins with dose of 7.2 g/day. Every 3-4 days the dose is increased by 4.8 g/day until maximum dose of 24 g/day in 2-3 intakes. Treatment is continued during the whole period of the disease. Every 6 months an attempt should be made to reduce a dose or cancel a drug, gradually reducing a dose by 1.2 g/day every 2 days.


Prevention of sickle cell vaso-occlusive crisis: The daily dose is 160 mg/kg body weight divided into 4 equal doses.


Treatment of dyslexia in children (as part of complex therapy): Recommended daily dose for children from 8 years and adolescents is 3.2 g divided into 2 doses.


For patients with impaired renal function, the dose should be adjusted depending on the CK value.


CK can be calculated based on serum creatinine concentration using the following formula:


For men, CK (ml/min) = [140 - age (years)] x body weight (kg)/72 x serum creatinine (mg/dL);


CK for women can be calculated by multiplying the value obtained by a factor of 0.85.

In elderly patients the dose is adjusted in the presence of renal insufficiency; in case of long-term therapy it is necessary to monitor renal function status.


No dose adjustment is required in patients with hepatic impairment.


Patients with both renal and hepatic dysfunction are prescribed the drug in the same manner as patients with only renal dysfunction.