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Nolvadex

Nolvadex
Nolvadex is an antiestrogen that is used in the treatment of breast cancer that spreads to other parts of the body. It is also used in combination with other medication to treat and prevent the risk of developing breast cancer.

Brand: Tamoxifen

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: March 2024
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Nolvadex 20 mg
360 pills - 20 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$221.93 $0.62 $125.47 Add to cart
270 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$173.95 $0.64 $86.60 Add to cart
180 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$122.93 $0.68 $50.77 Add to cart
120 pills - 20 mg $88.99 $0.74 $26.81 Add to cart
90 pills - 20 mg $71.99 $0.80 $14.86 Add to cart
60 pills - 20 mg $55.97 $0.93 $1.93 Add to cart
30 pills - 20 mg $28.95 $0.97 No Add to cart
Nolvadex 10 mg
360 pills - 10 mg $89.99 $0.25 $87.73 Add to cart
270 pills - 10 mg $75.03 $0.28 $58.26 Add to cart
180 pills - 10 mg $55.99 $0.31 $32.87 Add to cart
120 pills - 10 mg $41.99 $0.35 $17.25 Add to cart
90 pills - 10 mg $34.93 $0.39 $9.50 Add to cart
60 pills - 10 mg $25.79 $0.43 $3.83 Add to cart
30 pills - 10 mg $14.81 $0.49 No Add to cart

Product description

DRUG TITLE

Nolvadex (Tamoxifen)

Pharmacological action

Antitumor agent. Nolvadex (Tamoxifen) has a combined spectrum of pharmacological action - as an estrogen antagonist and agonist in different tissues. In patients with breast cancer in tumor cells, tamoxifen primarily has an anti-estrogenic effect, preventing estrogen from binding to estrogen receptors. Tamoxifen, as well as some of its metabolites compete with estradiol for binding sites with cytoplasmic estrogen receptors in breast, uterine, vaginal, anterior pituitary lobe tissues and tumors with high estrogen content. In contrast to the estrogen receptor complex tamoxifen receptor complex does not stimulate DNA synthesis in the nucleus, but inhibits cell division, which leads to regression of tumor cells and their death.


Pharmacokinetics

After oral administration, tamoxifen is well absorbed from the gastrointestinal tract. Cmax in serum is reached within 4 to 7 hours after a single dose. Css in serum is usually reached after 3-4 weeks. Binding to plasma proteins is 99%. Metabolized in the liver with the formation of several metabolites. Excretion of tamoxifen from the body is biphasic, with an initial T1/2 of 7 to 14 hours, followed by a slow terminal T1/2 over 7 days. It is excreted mainly in the form of conjugates, mainly in the feces; small amounts are excreted in the urine.

Contraindications to use

Hypersensitivity to Nolvadex (Tamoxifen); pregnancy, lactation (breast-feeding), children - depending on the dosage form.


With caution: renal failure, diabetes, eye disease (including cataracts), deep vein thrombosis and thromboembolic disease (including in the anamnesis), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, concomitant therapy with indirect anticoagulants.


Administration during pregnancy and lactation

It is contraindicated for use during pregnancy and lactation (breast-feeding). If it is necessary to use during lactation, breastfeeding should be stopped.


There are reports of spontaneous abortions, birth defects and fetal death in women taking tamoxifen during pregnancy, although a causal relationship has not been established.


Nolvadex (Tamoxifen) inhibits lactation.

Use in impaired renal function

Caution should be used in cases of renal insufficiency.


Administration in children

It is possible to use in children on prescription, in the recommended dosages and dosage forms. It is necessary to strictly follow the instructions in the tamoxifen preparations on contraindications for use in children of different ages of specific medicinal forms of tamoxifen.

Tamoxifen drug active ingredient indications

Breast cancer in menopausal women, breast cancer in men after castration, kidney cancer, melanoma (containing estrogen receptors), ovarian cancer; prostate cancer in resistance to other drugs.


Dosing regimen

The dosing regimen is established individually, depending on the indications, the patient's condition, and the antitumor therapy regimen used.