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Microzide

Microzide
Microzide is a moderate thiazide diuretic medication which decreases reabsorbtion of Na+ at the level of cortical limb of Henles' loop not influencing its segment located in medullary layer of the kidney.

Brand: Hydrochlorothiazide

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Package Price Per pill Save Order
Microzide 25 mg
360 pills - 25 mg
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$141.95 $0.39 $67.99 Add to cart
270 pills - 25 mg
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$111.05 $0.41 $46.41 Add to cart
180 pills - 25 mg $79.01 $0.44 $25.96 Add to cart
120 pills - 25 mg $55.95 $0.47 $14.03 Add to cart
90 pills - 25 mg $45.93 $0.51 $6.56 Add to cart
60 pills - 25 mg $34.99 $0.58 No Add to cart
Microzide 12.5 mg
270 pills - 12.5 mg $81.95 $0.30 $25.90 Add to cart
180 pills - 12.5 mg $58.95 $0.33 $12.95 Add to cart
90 pills - 12.5 mg $35.95 $0.40 No Add to cart

Product description

Drug Name

Microzide (Hydrochlorothiazide)

Pharmacological action

Thiazide diuretic. Disrupts reabsorption of sodium, chlorine and water ions in the distal tubules of the nephron. Increases excretion of potassium, magnesium, bicarbonate ions; delays calcium ions in the body. Diuretic effect comes in 2 hours, reaches a maximum in 4 hours and lasts up to 12 hours. Helps to reduce high blood pressure. In addition, it reduces polyuria in patients with diabetes mellitus (the mechanism of action is not fully understood). In some cases it reduces intraocular pressure in glaucoma.


Pharmacokinetics

After oral administration, 60-80% of the dose is absorbed from the gastrointestinal tract. Time to reach Cmax in plasma is 1.5-3 hours. Hydrochlorothiazide accumulates in erythrocytes. In excretion phase its concentration in erythrocytes is 3-9 times higher than in plasma. Binding to plasma proteins is 40-70%. Vd in the terminal phase of excretion is 3-6 l/kg (equivalent to 210-420 l at a body weight of 70 kg).


Hydrochlorothiazide is metabolized to a very small extent. Its only metabolite detected in trace amounts is 2-amino-4-chloro-M-benzenedisulfonamide.


Excretion of hydrochlorothiazide from plasma has biphasic character: T1/2 in initial phase is 2 hours, in terminal phase - about 10 hours. In patients with normal renal function excretion is carried out almost exclusively by the kidneys. In general, 50-75% of the dose taken orally is excreted unchanged in the urine.


In elderly patients and in patients with impaired renal function, clearance of hydrochlorothiazide is significantly reduced, which leads to a significant increase in its plasma concentrations. The decrease in clearance observed in elderly patients seems to be associated with impaired renal function. No changes in the pharmacokinetics of hydrochlorothiazide have been noted in patients with liver cirrhosis.

Contraindications to use

Severe renal insufficiency, anuria, severe hepatic insufficiency or hepatic encephalopathy (risk of hepatic coma), severe forms of gout and diabetes, refractory hypokalemia, hypercalcemia, hyponatremia, insufficiency of adrenal function (Addison's disease); I trimester of pregnancy, breast-feeding; children under 3 years (for solid dosage form); hypersensitivity to sulfonamides.

Administration during pregnancy and lactation

Application is contraindicated in the first trimester of pregnancy and during breast-feeding.

Use with caution in the second and third trimesters of pregnancy.

Hydrochlorothiazide is excreted with breast milk.


Administration in patients with liver dysfunction

Use is contraindicated in severe hepatic insufficiency or hepatic encephalopathy (risk of hepatic coma).

Administration in patients with impaired renal function

Administration in cases of severe renal insufficiency and anuria is contraindicated.

Administration in children

Administration in children under 3 years of age is contraindicated.

Indications of active substances of Microzide (Hydrochlorothiazide)

Arterial hypertension (as monotherapy or in combination therapy), edematous syndrome of various genesis (chronic heart failure, nephrotic syndrome, premenstrual syndrome, acute glomerulonephritis, chronic renal failure, portal hypertension, fluid retention in obesity, corticosteroid treatment), reduction of symptomatic polyuria in non-sugar diabetes, glaucoma (subcompensated forms), prevention of calcium-phosphate concrements formation in the urinary tract in hypercalciuria.


Dosing regimen

It is taken orally. Regimen of use depends on indications, clinical situation, concomitant diseases.


For adults, the single dose is 12.5-100 mg once daily.


For children over 3 years old the dose is 1-2 mg/kg/day or 30-60 mg/m2 body surface 1 time/day.