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Methotrexate

Methotrexate
Methotrexate is prescribed to treat certain types of breast, skin, head, neck or lung cancer. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.

Brand: Methotrexate

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: March 2024
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Methotrexate 10 mg
270 pills - 10 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$467.11 $1.73 $286.46 Add to cart
180 pills - 10 mg
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$342.01 $1.90 $160.37 Add to cart
120 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$250.88 $2.09 $84.04 Add to cart
90 pills - 10 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$205.27 $2.28 $45.92 Add to cart
60 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$148.22 $2.47 $19.24 Add to cart
30 pills - 10 mg $83.73 $2.79 No Add to cart
Methotrexate 7.5 mg
270 pills - 7.5 mg
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$353.77 $1.31 $202.52 Add to cart
180 pills - 7.5 mg
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$259.20 $1.44 $111.66 Add to cart
120 pills - 7.5 mg
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$188.47 $1.57 $58.77 Add to cart
90 pills - 7.5 mg
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$153.18 $1.70 $32.25 Add to cart
60 pills - 7.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$109.83 $1.83 $13.79 Add to cart
30 pills - 7.5 mg $61.81 $2.06 No Add to cart
Methotrexate 2.5 mg
270 pills - 2.5 mg
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$199.95 $0.74 $87.96 Add to cart
180 pills - 2.5 mg
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$134.95 $0.75 $56.99 Add to cart
120 pills - 2.5 mg $91.75 $0.76 $36.21 Add to cart
90 pills - 2.5 mg $74.99 $0.83 $20.98 Add to cart
60 pills - 2.5 mg $55.95 $0.93 $8.03 Add to cart
30 pills - 2.5 mg $31.99 $1.07 No Add to cart

Product description

Drug title

Methotrexate

Pharmacological action

Antitumor, cytostatic agent of antimetabolites group, inhibits dihydrofolate reductase, which takes part in reduction of dihydrofolic acid to tetrahydrofolic acid (carrier of carbon fragments required for synthesis of purine nucleotides and their derivatives).


Inhibits synthesis, DNA repair and cellular mitosis. Especially sensitive to the action are rapidly proliferating tissues: cells of malignant tumors, bone marrow, embryonic cells, epithelial cells of intestinal mucosa, bladder, oral cavity. Along with antitumor, it has immunosuppressive effect.


Pharmacokinetics

Absorption during oral administration depends on the dose: when administered with 30 mg/m2, absorption is good, the average bioavailability is 60%. Absorption is reduced when administered in doses greater than 80 mg/m2.


In children with leukemia, absorption ranges from 23% to 95%. Time to reach Cmax is 40 min to 4 h. Food slows down absorption and reduces Cmax. Binding with plasma proteins is about 50%, mainly with albumin.


After distribution in the tissues, high concentrations of methotrexate in the form of polyglutamates are found in the liver, kidneys and especially in the spleen, where methotrexate may be retained for weeks or even months.


When taken in therapeutic doses, it practically does not penetrate the blood-brain barrier. It penetrates into breast milk.


After oral administration it is partially metabolized by the intestinal flora, the main part is metabolized in the liver (regardless of the route of administration) to form the pharmacologically active polyglutamine form, which also inhibits dihydrofolate reductase and thymidine synthesis. The T1/2 in patients receiving less than 30 mg/m2 of the drug is 2-4 h in the initial phase and 3-10 h in the final phase (which is prolonged) when using low doses and 8-15 h when using high doses of the drug. In chronic renal failure both phases of drug excretion may be significantly prolonged.


The drug is excreted mainly unchanged by the kidneys through glomerular filtration and tubular secretion, up to 10% is excreted in bile (with subsequent reabsorption in the intestine). Excretion of the drug in patients with impaired renal function, marked ascites or transudate is significantly delayed. When reintroduced, it accumulates in tissues as polyglutamates.

Contraindications to use

Administration of methotrexate is contraindicated in pregnancy and during lactation, in marked changes in renal and liver function, in hematological disorders (such as bone marrow hypoplasia, leukopenia, thrombocytopenia, anemia), in the acute phase of infectious diseases, immunodeficiency syndrome, hypersensitivity to methotrexate or other components of the tablet, children under 3 years old.


With caution. In ascites, pleural effusion, gastric and duodenal ulcer, ulcerative colitis, dehydration, gout or nephrolithiasis in anamnesis, previous radiation therapy or chemotherapy, infectious diseases of viral, fungal or bacterial nature.


Administration during pregnancy and lactation

Has teratogenic action: can cause fetal death and congenital deformities. If a woman becomes pregnant during methotrexate therapy, decision should be made on whether to terminate the pregnancy, due to the risk of side effects on the fetus. Methotrexate is excreted with breast milk, and breastfeeding should be stopped during the entire course of treatment.


Administration in patients with liver dysfunction

Methotrexate is contraindicated in severe liver function abnormalities.

Administration in impaired renal function

Administration of methotrexate is contraindicated in marked changes in renal function.


Excretion is significantly delayed in patients with impaired renal function. When reintroduced, it accumulates in tissues as polyglutamates.


Administration in children

Administration of methotrexate is contraindicated in children under 3 years of age.

Indications of the drug Methotrexate

  • Acute lymphoblastic leukemia and non-Hodgkin's lymphoma;
  • trophoblastic tumors;
  • Mycosis fungoides in advanced stages;
  • severe forms of psoriasis;
  • Rheumatoid arthritis (when other therapies have failed).

Dosage regimen

Methotrexate tablets are used orally. Doses and timing of treatment are set individually depending on the chemotherapy regimen.


Trophoblastic tumors:

  • 15-30 mg orally daily for 5 days at intervals of one or more weeks (depending on signs of toxicity). Treatment courses are usually repeated 3 to 5 times.
  • 50 mg once every 5 days at intervals of at least 1 month. A course of treatment requires 300-400 mg.

Acute lymphoblastic leukemia (as part of complex therapy):


  • 3.3 mg/m2 in combination with prednisolone until remission is achieved, then 15 mg/m2 once weekly or 2.5 mg/kg every 14 days.


Non-Hodgkin's lymphoma (as part of complex therapy):

  • 15-20 mg/m2 in 1 dose 2 times a week;
  • 7.5 mg/m2 daily for 5 days.

Rheumatoid arthritis:


Initial dose is usually 7.5 mg once weekly, taken once daily or divided into three doses at 12-hour intervals. For optimal effect, the weekly dose may be increased, but should not exceed 20 mg. When optimal clinical effect is achieved, dose reduction should be started until the lowest effective dose is achieved. The optimal duration of therapy is not known. For juvenile chronic arthritis in children, doses of 10-30 mg/m2/week (0.3-1 mg/kg) are effective.


Psoriasis:


Methotrexate therapy is given in doses of 10 to 25 mg/week. The dose is usually increased gradually; when optimal clinical effect is achieved, dose reduction is initiated until the lowest effective dose is achieved.


Fungal mycosis:

  • 25 mg twice weekly. Dose reduction or discontinuation of the drug is determined by the patient's response and hematological parameters.