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Metformin is a biguanide antidiabetic that is used to treat type II diabetes. It works by reducing the amount of sugar that the liver produces and the intestines absorb.

Brand: Metformin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Metformin 850 mg
360 pills - 850 mg
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$193.91 $0.54 $76.03 Add to cart
270 pills - 850 mg
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$149.53 $0.55 $52.93 Add to cart
180 pills - 850 mg
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$104.99 $0.58 $29.98 Add to cart
120 pills - 850 mg $74.95 $0.62 $15.03 Add to cart
90 pills - 850 mg $59.99 $0.67 $7.50 Add to cart
60 pills - 850 mg $44.99 $0.75 No Add to cart
Metformin 500 mg
360 pills - 500 mg $95.95 $0.27 $40.01 Add to cart
180 pills - 500 mg $52.97 $0.29 $15.01 Add to cart
90 pills - 500 mg $33.99 $0.38 No Add to cart

Product description

Drug Name


Pharmacological action

Oral hypoglycemic drug of biguanide group (dimethylbiguanide). The mechanism of action of metformin is related to its ability to inhibit gluconeogenesis, as well as the formation of free fatty acids and fat oxidation. It increases the sensitivity of peripheral receptors to insulin and glucose utilization by cells. Metformin does not affect the amount of insulin in blood, but changes its pharmacodynamics by reducing the ratio of bound to free insulin and increasing the ratio of insulin to proinsulin.

Metformin stimulates glycogen synthesis by acting on glycogen synthetase. Increases transport capacity of all types of membrane glucose transporters. Delays glucose absorption in the intestine.

Reduces triglycerides, LDL, LDLNP. Metformin improves blood fibrinolytic properties by inhibiting tissue-type plasminogen activator inhibitor.

Against the background of metformin administration, the patient's body weight either remains stable or decreases moderately.


After oral administration metformin is slowly and incompletely absorbed from the gastrointestinal tract. Cmax in plasma is reached after about 2.5 hours. At a single dose of 500 mg absolute bioavailability is 50-60%. When concomitant food intake, absorption of metformin is reduced and delayed.

Metformin is rapidly distributed in the body tissues. It is practically not bound to plasma proteins. It accumulates in the salivary glands, liver and kidneys.

It is excreted unchanged by the kidneys. T1/2 from plasma is 2-6 hours.

Metformin may be cumulated in renal dysfunction.

Contraindications to use

Acute or chronic metabolic acidosis, diabetic ketoacidosis, diabetic precoma and coma; renal failure, renal dysfunction (CK<60 ml/min); dehydration, severe infection, hypoglycemic shock, which may lead to renal dysfunction; clinically expressed symptoms of acute and chronic diseases that may lead to the development of tissue hypoxia (including cardiac failure, acute myocardial infarction, respiratory failure); use of contrasting iodine-containing substances for intravascular administration (including cardiac failure, acute and chronic diseases). including heart failure, acute myocardial infarction, respiratory failure); use of iodine contrast agents for intravascular administration (including during IV urography, IV cholangiography, angiography, CT); acute alcohol intoxication, chronic alcoholism; hypersensitivity to metformin.

Administration during pregnancy and lactation

Adequate and strictly controlled safety studies of metformin use in pregnancy have not been conducted. Administration in pregnancy is possible in cases of extreme necessity, when the expected benefit of therapy for the mother exceeds the possible risk to the fetus. Metformin crosses the placental barrier.

Metformin is excreted in small amounts with breast milk, and the concentration of metformin in breast milk may be 1/3 of the concentration in mother's plasma. Side effects in newborns during breastfeeding against the background of metformin administration have not been observed. However, due to limited data, use during breastfeeding is not recommended. The decision to stop breastfeeding should be made taking into account the benefits of breastfeeding and the potential risk of side effects in the child.

Preclinical studies have shown that metformin has no teratogenic effect at doses that are 2-3 times higher than the therapeutic doses used in humans. Metformin has no mutagenic potential and has no effect on fertility.

Application in liver dysfunction

It is contraindicated in cases of marked liver dysfunction.

Administration in renal dysfunction

Significant renal dysfunction is contraindicated.

Administration in elderly patients

Metformin is not recommended for patients over 60 years of age because of the increased risk of lactic acidosis.

Metformin active ingredient indications

Type 2 diabetes mellitus (insulin-independent) in case of ineffective diet therapy and physical activity, in patients with obesity: in adults - as monotherapy or in combination with other oral hypoglycemic agents or with insulin; in children aged 10 years and older - as monotherapy or in combination with insulin.

Dosing regimen

It is taken orally, during or after meals.

The dose and frequency of administration depend on the therapy regimen, the patient's age and the dosage form used.