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Mellaril

Mellaril
Mellaril (Thioridazine) is used to treat psychotic disorders such as schizophrenia. It changes the actions of chemicals in your brain.

Brand: Thioridazine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: April 2024
Package Price Per pill Save Order
Mellaril 100 mg
360 pills - 100 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$525.55 $1.46 $241.85 Add to cart
180 pills - 100 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$270.99 $1.51 $112.71 Add to cart
120 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$188.85 $1.57 $66.95 Add to cart
90 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$149.99 $1.67 $41.86 Add to cart
60 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$108.99 $1.82 $18.91 Add to cart
30 pills - 100 mg $63.95 $2.13 No Add to cart
Mellaril 50 mg
360 pills - 50 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$409.93 $1.14 $249.95 Add to cart
180 pills - 50 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$223.95 $1.24 $105.99 Add to cart
120 pills - 50 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$165.99 $1.38 $53.97 Add to cart
90 pills - 50 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$134.51 $1.49 $30.46 Add to cart
60 pills - 50 mg $98.95 $1.65 $11.03 Add to cart
30 pills - 50 mg $54.99 $1.83 No Add to cart
Mellaril 25 mg
360 pills - 25 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$271.95 $0.76 $159.93 Add to cart
180 pills - 25 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$147.55 $0.82 $68.39 Add to cart
120 pills - 25 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$106.93 $0.89 $37.03 Add to cart
90 pills - 25 mg $85.55 $0.95 $22.42 Add to cart
60 pills - 25 mg $64.95 $1.08 $7.03 Add to cart
30 pills - 25 mg $35.99 $1.20 No Add to cart
Mellaril 10 mg
360 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$188.95 $0.52 $146.93 Add to cart
180 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$101.99 $0.57 $65.95 Add to cart
120 pills - 10 mg $75.03 $0.63 $36.93 Add to cart
90 pills - 10 mg $63.05 $0.70 $20.92 Add to cart
60 pills - 10 mg $46.95 $0.78 $9.03 Add to cart
30 pills - 10 mg $27.99 $0.93 No Add to cart

Product description

Drug Name

Mellaril (Thioridazine)

Pharmacological action

Antipsychotic agent (neuroleptic), piperidine derivative of phenothiazine. It has antipsychotic, moderate sedative (without pronounced lethargy) and antidyskinetic effects; antihistamine and antiemetic effects are weakly expressed. It has anticholinergic activity, causes hypotensive effect. Its intensity of action is inferior to that of pericyazine.


The mechanism of antipsychotic action is associated with blockade of postsynaptic dopamine receptors in mesolimbic structures of the brain. It also has an alpha-adrenoblocking effect and inhibits the release of pituitary and hypothalamic hormones. However, blockade of dopamine receptors increases pituitary prolactin release.


Central antiemetic effect is caused by inhibition or blockade of dopamine D2-receptors in chemoreceptor trigger zone of cerebellum, peripheral - by blockade of vagus nerve in GI tract.


Pharmacokinetics

Clinical data on the pharmacokinetics of thioridazine are limited.


Phenothiazines have high binding to plasma proteins. It is excreted mainly by the kidneys and partially with the bile.



Contraindications to use

Acute depression, comatose states, marked CNS depression, severe diseases of the cardiovascular system, blood diseases in anamnesis, children under 1 year of age, hypersensitivity to thioridazine.

Administration during pregnancy and lactation

During pregnancy, thioridazine may be used only under strict indications. Adequate and well-controlled safety studies of thioridazine in pregnancy have not been conducted. It should be borne in mind that neonates whose mothers received thioridazine at the end of pregnancy may show intoxication symptoms: excessive somnolence, tremor, hyperactivity. If it is necessary to use thioridazine during lactation, it is necessary to decide on stopping breast-feeding.

Administration in liver dysfunction

Patients with liver disease require regular monitoring of liver function.


Administration in patients with impaired renal function

Caution is advised when using in patients with renal insufficiency.


Administration in children

Contraindicated in children under 1 year of age.

Indications of active substances of the drug Mellaril (Thioridazine)

Schizophrenia, psychotic disorders accompanied by hyperactivity and agitation; severe behavioral disorders associated with psychotic disorders or neurological diseases, accompanied by aggressiveness, inability to concentrate for long periods, reduced resistance to development of frustration. Moderate to severe depression in adults; neuroses accompanied by anxiety, agitation, depressed mood, tension, sleep disturbances, fears; Huntington's disease.


Dosing regimen


Individual. When administered orally, daily dose for adults and children over 12 years of age is 20-800 mg/day, frequency of administration - 2-4 times/day. The course of treatment in high doses lasts not more than 5 weeks.


In children 1-5 years old 1 mg/kg/day, over 5 years old 75-100 mg/day, in severe cases 300 mg/day, 2-4 times a day.


The maximum daily dose for adults and children over 12 years is 800 mg.