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Macrobid

Macrobid
Macrobid is used to treat infections specific to urinary tract (acute cystitis).

Brand: Nitrofurantoin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
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Package Price Per pill Save Order
Macrobid 100 mg
360 pills - 100 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$453.99 $1.26 $265.41 Add to cart
180 pills - 100 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$247.95 $1.38 $111.75 Add to cart
120 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$179.93 $1.50 $59.87 Add to cart
90 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$145.91 $1.62 $33.94 Add to cart
60 pills - 100 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$103.95 $1.73 $15.95 Add to cart
30 pills - 100 mg $59.95 $2.00 No Add to cart
Macrobid 50 mg
360 pills - 50 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$239.99 $0.67 $62.86 Add to cart
180 pills - 50 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$133.29 $0.74 $18.14 Add to cart
120 pills - 50 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$100.95 $0.84 No Add to cart

Product description

Drug Title

Macrobid (Nitrofurantoin)

Pharmacological action

A broad-spectrum antimicrobial agent, a nitrofuran derivative. It has a bacteriostatic and bactericidal effect in urinary tract infections. Nitrofurantoin is active against Escherichia coli, Klebsiella spp.


It is effective mainly against urinary tract infections.


Pharmacokinetics

It is well absorbed from digestive tract. Bioavailability is 50% (food increases bioavailability). Absorption rate depends on the size of the crystals (microcrystalline form is characterized by fast solubility and absorption rate, short time to reach Cmax in urine). Binding to plasma proteins is 60%. Metabolized in the liver and muscle tissue. T1/2 is 20-25 min. It penetrates through the barrier of the human body, placental barrier and is excreted with breast milk. Completely excreted by the kidneys (30-50% - unchanged).

Contraindications to use

Severe renal excretory dysfunction, renal failure, oliguria, glucose-6-phosphate dehydrogenase deficiency, pregnancy, early childhood (less than 1 month), hypersensitivity to nitrofurantoin, Stage II-III heart failure, liver cirrhosis, chronic hepatitis, acute porphyria, lactation.

Usage during pregnancy and lactation

Nitrofurantoin is contraindicated in pregnancy and during lactation (breast-feeding).

Administration in patients with liver dysfunction

It is contraindicated in cirrhosis of the liver and chronic hepatitis.

Usage in kidney dysfunction

It is contraindicated in cases of marked impaired renal excretory function, renal failure, oliguria. Risk of peripheral neuropathy increase in patients with significant renal insufficiency.

Administration in children

Contraindicated in young children (under 1 month).

Indications of active substance Macrobid (Nitrofurantoin)

Infectious inflammatory diseases of the urinary tract (including pyelonephritis, cystitis), caused by microorganisms sensitive to nitrofurantoin.

Dosage regimen

The dosage for adults is 50-100 mg and the daily dose is 4 times per day. The daily dose for children is 5-7 mg/kg in 4 doses. The course of treatment is 7 days. If necessary, treatment may be continued for another 3 days (only after checking urine for sterility). Doses of nitrofurantoin should be reduced during long-term maintenance treatment.