Pharmacodynamics of the drug lotrisone

Clotrimazole is active against dermatophytes, yeast-like fungi, in particular Candida spp., As well as against Trichomonas, staphylococci and streptococci.

Pharmacokinetics

With the cutaneous application of the drug in therapeutic doses, the transdermal absorption of active substances into the blood is very insignificant. When applied to the skin, the rate of absorption of betamethasone depends on the state of the epidermal barrier (inflammation and skin diseases increase absorption). The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which may lead to an increased risk of systemic side effects.

Therapeutic indications of the drug lotrisone

Epidermophytosis of the feet, inguinal dermatomycosis, dermatomycosis of smooth skin, candidiasis caused by Candida albicans.

Method of administration and doses Lotrisone

Outwardly. Apply with rubbing movements to the affected area and the surrounding skin 2 times a day (morning and evening); with inguinal dermatomycosis, microsporia of smooth skin and candidiasis, the duration of the course is 2 weeks, with epidermophytosis of the feet - 4 weeks. Application of the cream for more than 4 weeks is not recommended.

Overdose

Symptoms: phenomena of hypercortisolism.

Treatment: gradual withdrawal of the drug. Symptomatic therapy. If necessary, correction of electrolyte disturbances.

Application during pregnancy and lactation, fertility

During pregnancy (especially in the first trimester), topical application of the ointment in pregnant women is allowed only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. In such cases, the use of the drug should be short-lived and limited to small areas of the skin.

It is not known whether the components of the drug are excreted in breast milk. Therefore, when prescribing the drug Akriderm® GK during lactation, it is recommended to stop breastfeeding.

Do NOT use Lotrisone Cream if:

• you are allergic to any ingredient in Lotrisone Cream

• You are taking pimozide or ergot alkaloids (eg ergotamine)

Contact your doctor or healthcare provider right away if any of these apply to you.

Side effects

Paresthesia, maculopapular rash, burning, itching, irritation and dryness of the skin, folliculitis, hypertrichosis, acne-like eruptions, hypopigmentation, perioral and allergic contact dermatitis, atrophic skin changes, maceration, striae, prickly heat, tingling sensation, urticaria, urticaria , swelling, secondary infection. In children: suppression of the function of the hypothalamic-pituitary-adrenal system, Cushing's syndrome, increased intracranial pressure.