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Lexapro

Lexapro
Lexapro is used for the treatment of depression and anxiety. It can also be used for other diseases based on doctors recommendations.

Brand: Escitalopram

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
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Package Price Per pill Save Order
Lexapro 20 mg
270 pills - 20 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$229.95 $0.85 $255.96 Add to cart
180 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$163.99 $0.91 $159.95 Add to cart
120 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$121.75 $1.01 $94.21 Add to cart
90 pills - 20 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$100.93 $1.12 $61.04 Add to cart
60 pills - 20 mg $79.99 $1.33 $27.99 Add to cart
30 pills - 20 mg $53.99 $1.80 No Add to cart
Lexapro 10 mg
270 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$184.92 $0.68 $156.45 Add to cart
180 pills - 10 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$130.99 $0.73 $96.59 Add to cart
120 pills - 10 mg $95.97 $0.80 $55.75 Add to cart
90 pills - 10 mg $76.95 $0.86 $36.84 Add to cart
60 pills - 10 mg $59.55 $0.99 $16.31 Add to cart
30 pills - 10 mg $37.93 $1.26 No Add to cart
Lexapro 5 mg
270 pills - 5 mg $85.99 $0.32 $84.79 Add to cart
180 pills - 5 mg $64.93 $0.36 $48.92 Add to cart
120 pills - 5 mg $53.99 $0.45 $21.91 Add to cart
90 pills - 5 mg $44.99 $0.50 $11.94 Add to cart
60 pills - 5 mg $37.95 $0.63 No Add to cart

Product description

Drug title

Lexapro (Escitalopram)

Pharmacological action

Antidepressant. Selectively inhibits serotonin reuptake; increases the concentration of the neurotransmitter in the synaptic cleft, enhances and prolongs the effect of serotonin on postsynaptic receptors. Lexapro (Escitalopram) binds to serotonin (5-HT), dopamine (D1 and D2) receptors, α-adreno-, m-cholinoreceptors, and benzodiazepine and opioid receptors.


Antidepressant effect usually develops 2-4 weeks after the start of treatment. The maximum therapeutic effect of treatment of panic disorder is achieved about 3 months after the start of treatment.


Pharmacokinetics

Absorption is not dependent on food intake. Bioavailability is 80%. Time to reach Cmax in plasma - 4 hours. Kinetics of escitalopram is linear. Css is reached after 1 week. The average Css is 50 nmol/L (20 to 125 nmol/L) and is reached at a dose of 10 mg/day. The apparent Vd is 12 to 26 l/kg. Binding to plasma proteins is 80%. Metabolized in the liver to active demethylated and didemethylated metabolites. After multiple uses, the average concentration of demethyl and didemethyl metabolites is 28-31% and less than 5% of the concentration of escitalopram, respectively. The metabolism of escitalopram to form a demethylated metabolite occurs mainly with the participation of CYP2C19, CYPZA4 and CYP2D6 isoenzymes. In persons with weak activity of CYP2C19 isoenzyme, the concentration of escitalopram may be 2 times higher than in persons with high activity of this isoenzyme. No significant changes in the drug concentrations are observed when CYP2D6 isoenzyme activity is weak. T1/2 after multiple administration is 30 hours. The main metabolites of escitalopram have a longer T1/2. Clearance is 0.6 l/min. Excitalopram and its major metabolites are excreted by the liver and most of them by the kidneys, partially excreted as glucuronides. T1/2 and AUC are increased in elderly patients.


Contraindications to use

Concomitant use of MAO inhibitors, children and adolescents under 15 years of age, pregnancy, lactation, hypersensitivity to escitalopram.


Administration during pregnancy and lactation

It is contraindicated for use during pregnancy and lactation (breast feeding).

Administration in patients with liver dysfunction

Use with caution in cirrhosis of the liver.

Administration in patients with impaired renal function

Caution should be exercised when using in patients with renal insufficiency (CKD less than 30 ml/min).

Administration in children

Contraindicated in children and adolescents under 15 years of age.


Administration in elderly patients

Caution should be exercised when used in elderly patients.

Indications of active substances of the drug Lexapro (Escitalopram)

Depression, panic disorder (including agoraphobia).


Dosing regimen

 The optimal dosing regimen is determined by the doctor. You should strictly follow the compliance of the dosage form used for the specific drug indications for use and the dosing regimen.

It is taken orally, regardless of meals. Depending on the indications, a single dose of 10-20 mg/day. The maximum daily dose is 20 mg. The duration of treatment is several months. When stopping the treatment, the dose should be gradually reduced over 1-2 weeks in order to avoid the occurrence of "withdrawal" syndrome.


For elderly patients (over 65 years), the recommended dose is 5 mg/day, the maximum daily dose is 10 mg.


In patients with impaired liver function, the recommended initial dose during the first 2 weeks of treatment is 5 mg/day. Depending on individual response, the dose may be increased to 10 mg/day.


For patients with weak CYP2C19 isoenzyme activity, the recommended initial dose during the first 2 weeks of treatment is 5 mg/day. Depending on individual response, the dose may be increased to 10 mg/day.