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Imodium

Imodium
Imodium is intended for the symptomatic treatment of acute diarrhea in adults and children over 12 years of age.

Brand: Loperamide

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: April 2024
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Imodium 2 mg
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Product description

Pharmacological action of the drug Imodium

Buy Imodium in Canada

Antidiarrheal agent. Reduces the tone and motility of intestinal smooth muscles, apparently due to binding to opioid receptors in the intestinal wall. Inhibits the release of acetylcholine and prostaglandins, reducing peristalsis and increasing the transit time of the contents through the intestines.

Increases the tone of the anal sphincter. The action occurs quickly and lasts 4-6 hours.

Pharmacokinetics

After oral administration, the absorption of loperamide is about 40%, it undergoes intensive metabolism during the "first pass" through the liver. A small amount of unchanged loperamide enters the systemic circulation. Does not penetrate the BBB.

Metabolized in the liver.

T1/2 is 9-14 hours. It is excreted through bile with feces in the form of conjugated metabolites, a small part is excreted in the urine.

Indications of the active substances of the drug Imodium®

Imodium is intended for the treatment of diarrhea

Symptomatic treatment of acute and chronic diarrhea of ​​various origins (including allergic, emotional, drug, radiation; with a change in diet and quality composition of food, with metabolic and absorption disorders; as an adjuvant for diarrhea of ​​infectious genesis ). Stool regulation in patients with ileostomy.

Dosing regimen of the drug Imodium

 Imodium drug packaging

For adults with acute diarrhea, the first dose is 4 mg, then 2 mg after each act of defecation in case of loose stools. In chronic diarrhea, the first dose is 2 mg, the maintenance dose is selected so that the stool frequency is 1-2 times a day (2-12 mg / day).

The maximum daily dose for adults is 16 mg.

Children aged 4-8 years - 1 mg 3-4 times / day for 3 days; 9-12 years old - 2 mg 4 times / day for 5 days.

Contraindications to use

Intestinal obstruction; constipation, bloating, subileus, acute dysentery (as monotherapy), acute ulcerative colitis, pseudomembranous colitis caused by the use of broad-spectrum antibiotics; children under 4 years of age, I trimester of pregnancy, hypersensitivity to loperamide.

Application during pregnancy and lactation

Contraindicated in the first trimester of pregnancy. In the II and III trimesters of pregnancy, loperamide can be prescribed in cases where the expected benefit of therapy to the mother outweighs the potential risk to the fetus.

Because small amounts of loperamide are found in breast milk, use during breastfeeding is not recommended.

Application for violations of liver function

Use with caution in patients with impaired liver function, with liver failure.

Use in children

Contraindicated in children under 4 years of age.

Special instructions

Use with caution in liver failure.

It should not be used in clinical situations when suppression of intestinal motility is required.

If there is no effect after 2 days of using loperamide, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea.

Use with caution in patients with impaired liver function.

In case of an overdose of loperamide, naloxone is used as an antidote.

Drug interactions

It is believed that with the simultaneous use of cholestyramine can reduce the effectiveness of loperamide.

When used simultaneously with co-trimoxazole, ritonavir increases the bioavailability of loperamide, which is due to the inhibition of its metabolism during the "first pass" through the liver.

In case of an overdose of loperamide, naloxone is used as an antidote.

Side effect

From the digestive system: abdominal pain, bloating, nausea, constipation, dry mouth.

From the side of the central nervous system: increased fatigue, drowsiness, dizziness.

Allergic reactions: skin rash.