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Ilosone is intended for the treatment of diphtheria, whooping cough, legionnaires' diseases, erythrasma, listeriosis, scarlet fever, amoebic dysentery; gonorrhea, conjunctivitis of newborns, pneumonia in children, genitourinary infections in pregnant women and other infections.

Brand: Erythromycin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Ilosone 500 mg
360 pills - 500 mg
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$323.99 $0.90 $150.37 Add to cart
240 pills - 500 mg
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$221.88 $0.92 $94.36 Add to cart
180 pills - 500 mg
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$173.63 $0.96 $63.55 Add to cart
120 pills - 500 mg
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$125.09 $1.04 $33.03 Add to cart
90 pills - 500 mg
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$100.72 $1.12 $17.87 Add to cart
60 pills - 500 mg $71.91 $1.20 $7.15 Add to cart
30 pills - 500 mg $39.53 $1.32 No Add to cart
Ilosone 250 mg
360 pills - 250 mg
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$197.93 $0.55 $158.35 Add to cart
180 pills - 250 mg
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$107.05 $0.59 $71.09 Add to cart
120 pills - 250 mg $77.33 $0.64 $41.43 Add to cart
90 pills - 250 mg $63.82 $0.71 $25.25 Add to cart
60 pills - 250 mg $47.61 $0.79 $11.77 Add to cart
30 pills - 250 mg $29.69 $0.99 No Add to cart

Product description

Pharmacological action of Ilosone

Buy Ilosone Erythromycin in Canada

Instructions for medical use approved by the Pharmacological Committee of the Ministry of Health of the Russian Federation

Bacteriostatic antibiotic from the macrolide group, reversibly binds to the 50S ribosome subunit in its donor part, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of proteins of microorganisms (does not affect the synthesis nucleic acids). When used in high doses, it can show bactericidal action. The spectrum of action includes gram-positive (Staphylococcus spp., Producing and non-producing penicillinase, including Staphylococcus aureus; Streptococcus spp. (Including Streptococcus pneumoniae, Streptococcus pyogenes), alpha-hemolytic Bacillus anthracis), groups Corynebacterium diphtheriae, Corynebacterium minutissimum) and gram-negative microorganisms (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., Including Legionella pneumophila) and other microorganisms: Mycoplasma spp. (including Mycoplasma pneumoniae), Chlamydia spp. (including Chlamydia trachomatis), Treponema spp., Rickettsia spp., Entamoeba histolytica, Listeria monocytogenes.

Resistant gram-negative bacilli: Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Salmonella spp. and others. The sensitive group includes microorganisms, the growth of which is delayed at an antibiotic concentration of less than 0.5 mg / l, medium-sensitive - 1-6 mg / l, moderately resistant and resistant - 6-8 mg / l.


Absorption - high. Food intake has no effect on oral forms of erythromycin in the form of a base, coated with an enteric coating. Cmax is achieved after oral administration in 2-4 hours. The connection with plasma proteins is 70-90%.

Bioavailability is 30-65%. It is distributed unevenly in the body. It accumulates in large quantities in the liver, spleen, and kidneys. In bile and urine, the concentration is ten times higher than the concentration in plasma. It penetrates well into the tissues of the lungs, lymph nodes, middle ear exudate, prostate secretions, semen, pleural cavity, ascitic and synovial fluids. The milk of lactating women contains 50% of the plasma concentration. Poorly penetrates the BBB, into the cerebrospinal fluid (its concentration is 10% of the drug content in plasma). In inflammatory processes in the membranes of the brain, their permeability to erythromycin increases slightly. It penetrates the placental barrier and enters the fetal bloodstream, where its content reaches 5-20% of the content in the mother's plasma.

It is metabolized in the liver (more than 90%), partially with the formation of inactive metabolites. T1/2 - 1.4-2 hours, with anuria - 4-6 hours. Excretion with bile - 20-30% unchanged, by the kidneys (unchanged) after oral administration - 2-5%.

Indications of the drug Erythromycin

Treatment of pneumonia in children with Ilosone Erythromycin

Bacterial infections caused by sensitive microflora:

  • diphtheria (including the carrier of bacteria);

  • whooping cough (including prevention);

  • trachoma;

  • brucellosis;

  • legionnaires' disease;

  • erythrasma;

  • listeriosis;

  • scarlet fever;

  • amoebic dysentery;

  • gonorrhea;

  • conjunctivitis of newborns;

  • pneumonia in children;

  • genitourinary infections in pregnant women caused by Chlamydia trachomatis;

  • primary syphilis (in patients allergic to penicillins);

  • uncomplicated chlamydia in adults (with localization in the lower urinary tract and rectum) with intolerance or ineffectiveness of tetracyclines;

  • ENT infections (tonsillitis, otitis media, sinusitis);

  • biliary tract infections (cholecystitis);

  • infections of the upper and lower respiratory tract (tracheitis, bronchitis, pneumonia);

  • infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, burns of the II-III degree, trophic ulcers);

  • infections of the mucous membrane of the eyes;

  • prevention of exacerbations of streptococcal infection (tonsillitis, pharyngitis) in patients with rheumatism;

  • prevention of infectious complications during medical and diagnostic procedures (including preoperative bowel preparation, dental interventions, endoscopy, in patients with heart defects).

Dosing regimen of the drug Ilosone

Appearance of the drug Ilosone Erythromycin


A single dose for adults and adolescents over 14 years old is 250-500 mg, the daily dose is 1-2 g. The interval between doses is 6 hours. In severe infections, the daily dose can be increased to 4 g.

Children from 4 months to 18 years old, depending on age, body weight and severity of infection - 30-50 mg / kg / day in 2-4 doses; children of the first 3 months of life - 20-40 mg / kg / day. For more severe infections, the dose may be doubled.

For the treatment of diphtheria carriage - 250 mg 2 times / day. The course dose for the treatment of primary syphilis is 30-40 g, the duration of treatment is 10-15 days.

With amoebic dysentery, adults - 250 mg 4 times / day, children - 30-50 mg / kg / day; course duration - 10-14 days.

With legionellosis - 500 mg-1 g 4 times / day for 14 days.

With gonorrhea - 500 mg every 6 hours for 3 days, then 250 mg every 6 hours for 7 days.

For preoperative bowel preparation in order to prevent infectious complications - by mouth, 1 g at 19 hours, 18 hours and 9 hours before the operation (only 3 g).

For the prevention of streptococcal infection (with tonsillitis, pharyngitis), adults - 20-50 mg / kg / day, children - 20-30 mg / kg / day, the duration of the course is at least 10 days.

For the prevention of septic endocarditis in patients with heart defects - 1 g each for adults and 20 mg / kg for children, 1 hour before a medical or diagnostic procedure, then 500 mg for adults and 10 mg / kg for children, again after 6 hours

with whooping cough - 40-50 mg / kg / day for 5-14 days. With pneumonia in children - 50 mg / kg / day in 4 divided doses, for at least 3 weeks. With genitourinary infections during pregnancy - 500 mg 4 times / day for at least 7 days or (with poor tolerance of such a dose) - 250 mg 4 times / day for at least 14 days.

In adults, with uncomplicated chlamydia and tetracyclines intolerance - 500 mg 4 times / day for at least 7 days.

Contraindications to the use of

Erythromycin is contraindicated for:

  • hypersensitivity to this antibiotic;

  • concomitant use of terfenadine, astemizole, colchicine or cisapride, pimozide;

  • a history of jaundice;

  • severe liver dysfunction;

  • during breastfeeding;

  • children under 3 years old.

Use during pregnancy and lactation

The drug can be prescribed to pregnant women only if absolutely necessary (if the expected benefit to the mother outweighs the potential risk to the fetus).

Erythromycin passes into breast milk, therefore, when prescribing a drug, women should refrain from breastfeeding.

Special instructions


Possible liver dysfunction with an increase in the level of hepatic aminotransferases and the development of hepatocellular and (or) cholestatic hepatitis with or without jaundice.

Prolongation of the QT interval

Taking erythromycin can cause prolongation of the QT interval and rare cases of arrhythmias. Cases of ventricular arrhythmias of the torsades de pointes type have been described in patients receiving erythromycin. Avoid the use of erythromycin with an increase in the QT interval, in patients with a high risk of arrhythmia (withrisk factors:

  • proarrhythmicuncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia), as well as in patients receiving class IA antiarrhythmics (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol). Elderly patients are more susceptible to prolongation of the QT interval.

Syphilis during pregnancy

Taking erythromycin during pregnancy does not create an adequate concentration to prevent congenital syphilis. Children born to women who received oral erythromycin during pregnancy to prevent early syphilis should receive appropriate treatment with penicillin.

Diarrhea associated with Clostridium difficile

The development of diarrhea is associated with the use of almost all antibacterial drugs, including erythromycin, and can range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to an overgrowth of Clostridium difficile, which produces toxins A and B that contribute to the development of diarrhea. Overproduction of toxins by Clostridium difficile strains can lead to high morbidity and mortality, as these infections may be refractory to antibiotic therapy and colectomy may be required. The possibility of developing Clostridium difficile-associated diarrhea should be considered in all patients with diarrhea following antibiotic use. A careful study of the history of patients with diarrhea within two months after administration of antibacterial drugs is necessary. If Clostridium difficile is suspected or confirmed to be the cause of diarrhea, antibiotic therapy not directed against Clostridium difficile should be discontinued. Treatment of diarrhea associated with Clostridium difficile should include correction of water-electrolyte balance, provision of parenteral nutrition, antibiotic therapy against Clostridium difficile; in some cases, surgical treatment may be considered.

Due to the presence of lactose in the preparation, it is not recommended for patients with congenital galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption.

It is not recommended to use hepatotoxic drugs simultaneously with erythromycin.

Alcohol should not be consumed during treatment with erythromycin.

Erythromycin and its derivatives, when taking hormonal contraceptives, can reduce their effect. It is recommended to additionally use non-hormonal methods of contraception.

Erythromycin may worsen the symptoms of myasthenia gravis.

Use with caution in children under 6 years of age who may have difficulty swallowing.

Influence on the ability to drive vehicles and service mechanical devices

There is no data on the effect of the drug on the ability to drive vehicles and service mechanical devices.



  • with acute intoxication, nausea, vomiting, and abdominal pain are characteristic. In case of chronic overdose, liver dysfunction (jaundice, hepatitis) develops, up to acute liver failure, often accompanied by fever, leukocytosis, eosinophilia. Allergic skin reactions, anaphylactic shock, in rare cases, cholestatic hepatitis and even temporary hearing loss can occur, especially in patients with renal insufficiency.


  • urgent gastric lavage with activated charcoal is necessary (monitor the patient's condition to avoid aspiration!), Careful monitoring of the state of the respiratory system (if necessary, artificial ventilation of the lungs), acid-base balance and electrolyte metabolism, ECG indicators. Gastric lavage is effective when taking a dose that is five times the average therapeutic dose. Hemodialysis, peritoneal dialysis, and forced diuresis are ineffective. With the development of anaphylactic conditions - adrenaline, antihistamines, corticosteroids.

Drug Interactions

Serious adverse reactions have been reported in patients taking erythromycin concomitantly with CYP3A4 substrates. These include an increase in the toxicity of colchicine, an increased risk of rhabdomyolysis when used concomitantly with simvastatin, lovastatin, atorvastatin, and hypotension when used concomitantly with calcium channel blockers metabolized by CYP3A4 (verapamil, amlodipine, diltiazem). Erythromycin and colchicine interactions are potentially life-threatening and can occur with both drugs at the recommended doses. Rhabdomyolysis with possible renal failure may develop in critically ill patients receiving lovastatin concomitantly with erythromycin. In patients receiving concomitant lovastatin and erythromycin, the levels of creatine kinase (CK) and serum transaminases should be carefully monitored.

With the simultaneous use of erythromycin with theophylline, aminophylline, caffeine, cyclosporine, as well as with drugs that are metabolized in the liver (carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, disopyramide, bromocriptine), an increase in their concentration in the blood plasma and bromocriptine is noted. toxic action.

When taken simultaneously with terfenadine or astemizole, the development of arrhythmias (fibrillation and flutter of the ventricles, ventricular tachycardia, up to death) is possible; with dihydroergotamine or non-hydrogenated ergot alkaloids, vasoconstriction to spasm, dysesthesia is possible.

Erythromycin reduces the clearance of triazolam and midazolam and therefore can enhance the pharmacological effects of benzodiazepines, slows down the elimination (enhances the effect) of methylprednisolone, felodipine and coumarin anticoagulants.

Erythromycin increases the bioavailability of sildenafil, digoxin. When taken simultaneously with erythromycin, the dose of sildenafil should be reduced.

Drugs that block tubular secretion lengthen the T1/2 of erythromycin.

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism). Erythromycin reduces the bactericidal effect of β-lactam antibiotics (penicillins, cephalosporins, carbapenems).

Erythromycin reduces the effectiveness of hormonal contraception.

Side effects

From the digestive system:

  • nausea, vomiting, epigastric pain, cholestatic jaundice, tenesmus, diarrhea, dysbiosis;

  • rarely - pseudo-membranous enterocolitis, liver dysfunction, increased activity of hepatic transaminases, pancreatitis.

Allergic reactions:

  • skin rash, urticaria, eosinophilia;

  • rarely - anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis, interstitial nephritis, some rare cases of pancreatitis and seizures.

Effects due to chemotherapeutic action:

  • oral candidiasis, vaginal candidiasis. Cases of pseudomembranous colitis have been described during or after antibiotic therapy.

From the senses:

  • reversible ototoxicity - hearing loss and / or tinnitus (when using high doses - more than 4 g / day).

From the side of the cardiovascular system:

  • rarely - tachycardia, prolongation of the QT interval, atrial fibrillation and / or atrial flutter (in patients with an initially prolonged QT interval).