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Ibuprofen is used as an analgesic and anti-inflammatory agent in the treatment of rheumatoid arthritis (including juvenile rheumatoid arthritis or Still's disease), ankylosing spondylitis, osteoarthritis, and other non-rheumatoid (seronegative) arthropathies.

Brand: Ibuprofen

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Ibuprofen 600 mg
90 pills - 600 mg $31.99 $0.36 $21.80 Add to cart
60 pills - 600 mg $28.95 $0.48 $6.91 Add to cart
30 pills - 600 mg $17.93 $0.60 No Add to cart
Ibuprofen 400 mg
90 pills - 400 mg $29.99 $0.33 $14.86 Add to cart
60 pills - 400 mg $23.95 $0.40 $5.95 Add to cart
30 pills - 400 mg $14.95 $0.50 No Add to cart
Ibuprofen 200 mg
90 pills - 200 mg $21.95 $0.24 $11.02 Add to cart
60 pills - 200 mg $17.99 $0.30 $3.99 Add to cart
30 pills - 200 mg $10.99 $0.37 No Add to cart

Product description

Pharmacological action of the drug Ibuprofen

BUy Ibuprofen in Canada

The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). It has analgesic, antipyretic and anti-inflammatory effects. Blocks COG1 and COG2 indiscriminately.

The mechanism of action of ibuprofen is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.


Absorption - high, rapidly and almost completely absorbed from the gastrointestinal tract. Cmax ibuprofen plasma achieved 1-2 hours after dosing. Communication with plasma proteins is more than 90%, T1/2 - 2 hours. Slowly penetrates into the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized. It is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with bile.

Indications of the drug Ibuprofen

Appointment of ibuprofen in arthritis

  • inflammatory diseases of the joints and spine (including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, gouty arthritis);

  • moderate pain syndrome of various etiologies (including headache, migraine, toothache, neuralgia, myalgia, postoperative pain, post-traumatic pain, primary algodismenorrhea);

  • febrile syndrome with "colds" and infectious diseases;

  • intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Dosing regimen of the Ibuprofen

Ibuprofen packaging

Ibuprofen is prescribed for adults and children over 12 years of age by mouth, in tablets of 200 mg 3-4 times a day. To achieve a quick therapeutic effect, the dose can be increased to 400 mg (2 tablets) 3 times a day. When the therapeutic effect is achieved, the daily dose of the drug is reduced to 600-800 mg. The morning dose is taken before meals with plenty of water (for faster absorption of the drug). The remaining doses are taken throughout the day after meals.

The maximum daily dose is 1200 mg (do not exceed 6 tablets in 24 hours). A repeated dose should be taken no more often than after 4 hours. The duration of the drug use without consulting a doctor is no more than 5 days.

Do not use in children under 12 years of age without consulting a doctor.

Children from 6 to 12 years old: 1 tablet no more than 4 times a day; the drug can be used only if the child's body weight is more than 20 kg. The interval between taking the tablets is at least 6 hours (daily dose is not more than 30 mg / kg).

Contraindications to the use of Ibuprofen

  • hypersensitivity to any of the ingredients that make up the drug. Hypersensitivity to acetylsalicylic acid or other NSAIDs, incl. anamnestic data about an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs; complete or incomplete syndrome of intolerance to acetylsalicylic acid (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);

  • erosive and ulcerative diseases of the gastrointestinal tract in the stage of exacerbation (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis);

  • inflammatory bowel disease;

  • hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis;

  • period after coronary artery bypass grafting;

  • gastrointestinal bleeding and intracranial hemorrhage;

  • severe liver failure or active liver disease;

  • progressive kidney disease;

  • severe renal failure with creatinine clearance less than 30 ml / min, confirmed hyperkalemia;

  • pregnancy;

  • children under 6 years of age.

Application during pregnancy and lactation

Contraindicated in pregnancy. Use with caution during lactation.

Application for violations of liver function

Contraindicated in severe liver failure or active liver disease.

Application for impaired renal function

Contraindicated in progressive renal disease, severe renal failure with creatinine clearance less than 30 ml / min.

Use in children

Contraindicated in children under 6 years of age. Do not use in children under 12 years of age without consulting a doctor.

Use in elderly patients

Precautions: old age.

Special instructions

Treatment with the drug should be carried out in the minimum effective dose, the minimum possible short course. During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is shown, including esophagogastroduodenoscopy, a general blood test (determination of hemoglobin), and fecal occult blood test.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all types of activities that require increased attention, quick mental and motor reactions. It is not recommended to take ethanol during the treatment period.


Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

Treatment: gastric lavage (only within 1 hour after ingestion), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy.

Drug Interactions

Simultaneous administration of ibuprofen with acetylsalicylic acid and other NSAIDs is not recommended. With the simultaneous administration of ibuprofen, it reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When administered with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Concomitant use with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of serious gastrointestinal bleeding.

Cefamandol, cephaperazone, cefotetan, valproic acid, plikamycin, increase the incidence of hypoprothrombinemia. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication. Microsomal oxidation inhibitors - reduce the risk of hepatotoxic effects. Reduces the hypotensive activity of vasodilators, natriuretic and diuretic activity in furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increased risk of hemorrhagic disorders), enhances the ulcerogenic effect with bleeding of mineralocorticosteroids, glucocorticosteroids, colchicine, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs and insulin, sulfonylurea derivatives. Antacids and cholestyramine reduce absorption. Increases the concentration in the blood of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.


Side effect

Gastrointestinal tract (GIT): NSAID gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding); irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gingival mucosa, aphthous stomatitis, pancreatitis.

Hepato-biliary system: hepatitis.

Respiratory system: shortness of breath, bronchospasm.

Sense organs: hearing impairment: hearing loss, ringing or tinnitus; visual impairment: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dry and irritated eyes, edema of the conjunctiva and eyelids (allergic genesis).

Central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).

Cardiovascular system: heart failure, tachycardia, increased blood pressure.

Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.

Allergic reactions: skin rash (usually erythematous or urticaria), pruritus, Quincke's edema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal syndrome , eosinophilia, allergic rhinitis.

Hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.

Others: increased sweating.

The risk of ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision disorders, scotoma, amblyopia) increases with prolonged use in high doses.

Laboratory indicators:

  • bleeding time (may increase);

  • serum glucose concentration (may decrease);

  • creatinine clearance (may decrease);

  • hematocrit or hemoglobin (may decrease);

  • serum creatinine concentration (may increase);

  • activity of "hepatic" transaminases (may increase).

If side effects occur, you should stop taking the drug and consult a doctor.