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Hytrin

Hytrin
Hytrin is indicated for hypertension, benign prostatic hyperplasia.

Brand: Terazosin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: November 2023
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Package Price Per pill Save Order
Hytrin 5 mg
120 pills - 5 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$224.93 $1.87 $148.63 Add to cart
90 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$180.91 $2.01 $99.26 Add to cart
60 pills - 5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$135.93 $2.27 $50.85 Add to cart
30 pills - 5 mg $93.39 $3.11 No Add to cart
Hytrin 2 mg
240 pills - 2 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$373.99 $1.56 $214.09 Add to cart
180 pills - 2 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$282.95 $1.57 $158.11 Add to cart
120 pills - 2 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$208.99 $1.74 $85.05 Add to cart
90 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$167.95 $1.87 $52.58 Add to cart
60 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$123.92 $2.07 $23.10 Add to cart
30 pills - 2 mg $73.51 $2.45 No Add to cart
Hytrin 1 mg
240 pills - 1 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$199.99 $0.83 $106.09 Add to cart
180 pills - 1 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$154.99 $0.86 $74.57 Add to cart
120 pills - 1 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$108.99 $0.91 $44.05 Add to cart
90 pills - 1 mg $85.48 $0.95 $29.30 Add to cart
60 pills - 1 mg $62.99 $1.05 $13.53 Add to cart
30 pills - 1 mg $38.26 $1.28 No Add to cart

Product description

Pharmacological action of Hytrin

Buy Hytrin in Canada

Selective blocker of postsynaptic α1-adrenergic receptors. By blocking these receptors of resistive (arterial) vessels, it causes their expansion, a decrease in OPSS and a decrease in blood pressure. Reduces afterload on the heart. It also causes a decrease in the tone of the capacitive (venous) vessels, reduces the preload on the heart. Unlike non-selective blockers α1- and α2-adrenergic receptors does not cause severe tachycardia.

Terazosin has some hypolipidemic effect: against the background of its use, a decrease in the level of cholesterol, LDL and VLDL is observed (the mechanism of these effects has not been clarified). In addition, terazosin normalizes urination in patients with benign hypertrophy (adenoma) of the prostate gland, because by blocking the postsynaptic α1-adrenergic receptors of the smooth muscles of the triangle and the bladder neck, proximal urethra and prostate gland, it reduces resistance to urine flow.

Pharmacokinetics

After oral administration, it is rapidly and completely absorbed from the intestine. Absorption does not depend on food intake; bioavailability is over 90%. Cmax is achieved after 1 hour. Plasma protein binding is 90-94%. It is metabolized in the liver with the formation of 4 metabolites, one of which (piperazine derivative of terazosin) has hypotensive activity.

T1/2 - 12 hours. It is excreted in the bile (60%) and kidneys (40%, of which 10% - unchanged). With hepatic failure, clearance is reduced.

Indications of the active substances of the drug Terazosin

Hytrin is indicated for hypertension

Arterial hypertension, benign prostatic hyperplasia.

Dosage regimen of Hytrin

Treatment should be started with a low dose of 1 mg, taken immediately before bedtime, after which the patient should be in bed for several hours. The dose is increased gradually once a week. The maintenance dose, depending on the indications and the effectiveness of treatment, is 1-10 mg 1 time / day.

The maximum daily dose is 20 mg.

Special instructions

To prevent the occurrence of the first dose phenomenon, treatment should be started with the minimum effective dose (1 mg / day before bedtime), after which the patient should be in bed for 6-8 hours.

The risk of orthostatic hypotension (the "first dose" phenomenon) is highest in within 30-90 minutes after taking the drug and increased in patients simultaneously receiving beta-blockers and diuretics, with a decrease in the volume of fluid in the body, a hypersaline diet, and also when the drug is resumed after a break (several days).

In case of temporary cessation of treatment, therapy is resumed with the same dose.

During treatment, the concentration of prostate specific antigen (PSA) does not change.

Before starting treatment for benign prostatic hyperplasia, it is necessary to exclude prostate cancer. The effectiveness of the therapy for this disease is assessed after 4-6 weeks of treatment with maintenance doses.

The patient should be informed of the increased risk of orthostatic hypotension withconsumption ethanol, prolonged standing or exercise, and in hot weather.

Within 12 hours after taking the first dose, after increasing the dosage or interrupting therapy, caution should be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

What other drugs will affect Hitrin?

Tell your doctor about all other drugs you use, especially:

  • sildenafil (Viagra, Revatio);

  • Tadalafil (Cialis);

  • Vardenafil (Levitra);

  • Verapamil (Calan, Covera, Isoptin, Verelan); or

  • other blood pressure medications, including diuretics (water tablets).

 

Side effects

Asthenia, blurred vision, nasal congestion, nausea, peripheral edema, a tendency to increase in body weight in patients; decrease in hematocrit, hemoglobin, leukocytes, total protein and albumin in the blood.