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Glucovance

Glucovance
Glucovance is a combination of two orally taken drugs possessing a hyproglycemic effect. Used to treat type 2 diabetes.

Brand: Metformin & Glyburide

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: April 2024
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Package Price Per pill Save Order
Glucovance 500/5 mg
360 pills - 500/5 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$309.99 $0.86 $216.93 Add to cart
240 pills - 500/5 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$209.99 $0.87 $141.29 Add to cart
180 pills - 500/5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$162.95 $0.91 $100.51 Add to cart
120 pills - 500/5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$115.75 $0.96 $59.89 Add to cart
90 pills - 500/5 mg $91.79 $1.02 $39.94 Add to cart
60 pills - 500/5 mg $67.95 $1.13 $19.87 Add to cart
30 pills - 500/5 mg $43.91 $1.46 No Add to cart
Glucovance 400/2.5 mg
360 pills - 400/2.5 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$201.05 $0.56 $266.83 Add to cart
240 pills - 400/2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$150.55 $0.63 $161.37 Add to cart
180 pills - 400/2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$129.55 $0.72 $104.39 Add to cart
120 pills - 400/2.5 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$103.95 $0.87 $52.01 Add to cart
90 pills - 400/2.5 mg $81.95 $0.91 $35.02 Add to cart
60 pills - 400/2.5 mg $60.55 $1.01 $17.43 Add to cart
30 pills - 400/2.5 mg $38.99 $1.30 No Add to cart

Product description

Drug Name

Glucovance (Metformin & Glyburide)

Pharmacological action

Glucovance (Metformin & Glyburide) is a fixed combination of two oral hypoglycemic agents of different pharmacological groups: metformin and glibenclamide.


Metformin belongs to the group of biguanides and reduces both basal and postprandial plasma glucose levels. Metformin does not stimulate insulin secretion and therefore does not cause hypoglycemia. It has 3 mechanisms of action:


Reduces glucose production by the liver by inhibiting gluconeogenesis and glycogenolysis;

increases the sensitivity of peripheral receptors to insulin, glucose consumption and utilization by cells in muscles;

Delays glucose absorption in the gastrointestinal tract.

The drug also has a favorable effect on blood lipid composition, reducing the level of total cholesterol, LDL and TG.


Glibenclamide belongs to the group of sulfonylurea derivatives of II generation. Glucose content when taking glibenclamide decreases as a result of stimulation of insulin secretion by pancreatic β-cells.


Metformin and glibenclamide have different mechanisms of action, but mutually complement the hypoglycemic activity of each other. The combination of two hypoglycemic agents has a synergistic effect on glucose reduction.


Contraindications for use

  • Hypersensitivity to metformin, glibenclamide or other sulfonylurea derivatives and excipients;
  • diabetes mellitus type 1;
  • diabetic ketoacidosis; diabetic precoma, diabetic coma;
  • Renal insufficiency or impaired renal function (CKD <60 ml/min);
  • acute conditions that can lead to changes in renal function: dehydration, severe infection, shock, intravascular administration of iodine-containing contrast agents;
  • Acute or chronic diseases accompanied by tissue hypoxia: cardiac or respiratory failure, recent myocardial infarction, shock;
  • hepatic insufficiency;
  • porphyria;
  • pregnancy, period of breastfeeding;
  • concomitant use of miconazole;
  • Extensive surgical operations;
  • chronic alcoholism, acute alcohol intoxication;
  • lactoacidosis (including in the anamnesis);
  • compliance with a hypocaloric diet (less than 1000 calories per day);

It is not recommended to use the drug in patients over 60 years of age who perform heavy physical work, which is associated with an increased risk of lactoacidosis in them.


Glucovance (Metformin & Glyburide) contains lactose, therefore its use is not recommended in patients with rare hereditary diseases associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.


With caution: febrile syndrome, adrenal insufficiency, hypofunction of the anterior pituitary gland, thyroid disease with uncompensated thyroid dysfunction.

Administration during pregnancy and lactation

Administration of the drug is contraindicated during pregnancy. The patient should be warned that during treatment with Glucovance (Metformin & Glyburide) it is necessary to inform the physician about the planned pregnancy and occurrence of pregnancy. If pregnancy is planned, as well as in case of pregnancy during the period of Glucovans® treatment, the drug should be cancelled and insulin treatment should be prescribed.


Glucovance (Metformin & Glyburide) is contraindicated during breastfeeding because there is no data on its ability to penetrate into the breast milk.

Indications for Glucovance (Metformin & Glyburide)

Type 2 diabetes mellitus in adults:


When diet therapy, exercise therapy and prior monotherapy with metformin or a sulfonylurea derivative are ineffective;

for replacement of previous therapy with two drugs (metformin and sulfonylurea derivative) in patients with stable and well-controlled glycemia levels.

Dosing regimen

The drug dose is determined by the physician individually for each patient, depending on the level of glycemia.


The initial dose is 1 tablet of Glucovans® 2.5 mg + 500 mg or Glucovans® 5 mg + 500 mg once daily. To avoid hypoglycemia, the starting dose should not exceed the daily dose of glibenclamide (or the equivalent dose of another previously taken sulfonylurea drug) or metformin if used as first-line therapy. It is recommended that the dose be increased by no more than 5 mg of glibenclamide + 500 mg of metformin per day every 2 or more weeks to achieve adequate blood glucose control.


Substitution for prior combination therapy with metformin and glibenclamide: The starting dose should not exceed the daily dose of glibenclamide (or equivalent dose of another sulfonylurea drug) and metformin taken previously. Every 2 or more weeks after the start of treatment, the dose of the drug is adjusted according to the level of glycemia.


Maximal daily dose is 4 tablets of Glucovans® 5 mg + 500 mg or 6 tablets of Glucovans® 2.5 mg + 500 mg.


Dosing regimen


The dosing regimen depends on the individual prescription:


For 2.5 mg+500 mg and 5 mg+500 mg dosages:


1 time daily, in the morning during breakfast - When prescribed 1 tablet per day;

2 times a day, in the morning and in the evening, when 2 or 4 tablets per day are prescribed.

For 2.5 mg+500 mg dosage:


3 times daily, morning, afternoon, and evening, when prescribing 3, 5, or 6 tablets per day.

For 5 mg+500 mg dosage:


3 times/day, morning, afternoon, and evening, when 3 tablets per day are prescribed.

The tablets should be taken with food. Each intake of the drug should be accompanied by a meal containing enough carbohydrates to prevent hypoglycemia.


Elderly patients


The dose of the drug is selected based on the state of kidney function. The initial dose should not exceed 1 tablet of Glucovans® 2.5 mg+500 mg. Improvement of renal function should be done at regular intervals.


Children


Glucovans® is not recommended for use in children.