|Frumil 5 mg|
|300 pills - 5 mg||$62.93||$0.21||$27.04||Add to cart|
|200 pills - 5 mg||$47.95||$0.24||$12.03||Add to cart|
|100 pills - 5 mg||$29.99||$0.30||No||Add to cart|
Pharmacological action of Frumil
Potassium-sparing diuretic. Is a derivative of pyrosinoylguanidine. Acts mainly on the distal part of the renal tubules. Increases the excretion of sodium and chlorine ions and reduces the excretion of potassium ions. It causes a less pronounced diuretic effect than thiazide diuretics. When combined with potassium-excreting diuretics, it reduces the risk of hypokalemia and hypomagnesemia.
After oral administration, amiloride is completely absorbed from the gastrointestinal tract. Bioavailability is about 50% and decreases when taken with food. Plasma protein binding is negligible. T1/2 is 6-9 hours, in the final phase - 20 hours or more. It is excreted by the kidneys unchanged.
Indications of the active substance Frumil (AMILORIDE)
Edema syndrome of various origins (including in chronic heart failure, nephrotic syndrome, liver cirrhosis), arterial hypertension.
Dosing regimen of Frumil
Individual. For oral administration, the daily dose is 2.5-20 mg.
The maximum daily dose is 40 mg.
Contraindications for use
Severe renal dysfunction, hyperkalemia, hepatic coma, hypersensitivity to amiloride.
Application for violations of liver function
Contraindicated in hepatic coma.
Application for impaired renal function
Contraindicated in severe renal impairment.
Use in children
Use with caution in children.
Use in elderly patients
Use with caution in elderly patients to avoid the risk of hyperkalemia.
Amiloride is usually used in combination with other diuretics that cause hypokalemia (including hydrochlorothiazide).
With the simultaneous use of ACE inhibitors (including captopril, enalapril), the risk of hyperkalemia increases, because ACE inhibitors reduce aldosterone levels, which leads to potassium retention in the body.
With the simultaneous use of amiloride and "loop" diuretics, thiazide diuretics (including hydrochlorothiazide) and other diuretics that cause hypokalemia, the excretion of potassium decreases.
With the simultaneous use of potassium preparations, other potassium-sparing diuretics, substitutes for table salt and dietary supplements containing potassium, severe, life-threatening hyperkalemia may develop.
With the simultaneous use of amiloride and amoxicillin, a slight decrease in the absorption of amoxicillin from the gastrointestinal tract is possible.
In healthy volunteers, amiloride does not significantly affect the concentration of digoxin in blood plasma, but reduces its positive inotropic effect. In patients with impaired renal function, an increase in the concentration of digoxin in the blood plasma is possible.
With the simultaneous use of amiloride and candesartan, eprosartan, losartan, telmisartan, valsartan, the risk of hyperkalemia increases.
With the simultaneous use of a combination of amiloride with hydrochlorothiazide and trimethoprim, hyponatremia may develop, which is due to the additive effect of diuretics and trimethoprim.
With the simultaneous use of amiloride and quinidine, the effectiveness of quinidine decreases.
Possible: nausea, vomiting, headaches, hyperkalemia.