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Fosamax

Fosamax
Fosamax is prescribed for the treatment of Paget's disease, malignant hypercalcemia, postmenopausal osteoporosis, osteoporosis in men, osteoporosis caused by long-term use of glucocorticosteroids.

Brand: Alendronate

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: December 2023
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Fosamax 70 mg
120 pills - 70 mg
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96 pills - 70 mg
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60 pills - 70 mg
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48 pills - 70 mg
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12 pills - 70 mg $65.99 $5.50 No Add to cart
Fosamax 35 mg
96 pills - 35 mg
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$241.95 $2.52 $133.97 Add to cart
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24 pills - 35 mg $87.94 $3.66 $6.04 Add to cart
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Product description

Pharmacological action of Fosamax

Buy fosamax in Canada

Bone resorption inhibitor. Aminobisphosphonate is an analogue of pyrophosphate. The mechanism of action is associated with the suppression of osteoclast activity. Stimulates osteogenesis, restores a positive balance between bone resorption and restoration, progressively increases bone mineral density (regulates calcium-phosphorus metabolism), promotes the formation of bone tissue with a normal histological structure.

Pharmacokinetics

Taking alendronic acid immediately before, during or after a meal leads to a decrease in bioavailability. When taken with coffee or orange juice, the bioavailability of alendronate sodium is reduced by approximately 60%.

After oral administration in therapeutic doses, the concentration of alendronate in blood plasma is usually below the lowest concentration that can be determined (less than 5 ng / ml).

It is temporarily distributed in soft tissues, then quickly redistributed to the bones or excreted in the urine. Plasma protein binding is approximately 78%. Not metabolized. It is excreted mainly by the kidneys. T1/2 in the final phase can be more than 10 years, which is associated with the release of the active substance from the bones.

Indications of active substances of the drug Fosamax®

Fosamax for the treatment of osteoporosis in women

Treatment and prevention of osteoporosis in postmenopausal women. Treatment of osteoporosis in men with the aim of increasing bone mass. Treatment of osteoporosis caused by the use of GCS in men and women. Paget's disease (bone damage) in men and women.

Dosing regimen of Fosamax

Fosamax drug packaging

Individual, depending on the indications.


Contraindications to use

Esophageal stricture, achalasia, inability of the patient to stand or sit upright for at least 30 minutes after taking the drug, hypocalcemia, hypersensitivity to alendronic acid.

Application during pregnancy and lactation

Adequate and strictly controlled clinical studies of the safety of the use of alendronic acid during pregnancy and lactation have not been conducted. If necessary, use during lactation, breastfeeding should be discontinued.

In experimental studies on rats, it was shown that alendronic acid at doses of 2 mg / kg / day and above causes discoordination of labor due to hypocalcemia; at doses over 5 mg / kg / day, a decrease in fetal weight was noted.

Application for impaired renal function

Not recommended for severe impaired renal function.

Use in children

Not recommended for use in children.

Special instructions

Not recommended for use in severe renal impairment, as well as in children.

It is used with caution in diseases of the gastrointestinal tract in the acute phase.

Before starting treatment, patients with mineral metabolism disorders should be fully corrected.

The interval between taking alendronic acid and other drugs should be at least 1 hour.

Drug interaction

When taken orally with other drugs and drugs containing calcium, the absorption of alendronic acid is impaired.

In postmenopausal women who received estrogens, there were no side effects associated with the use of alendronic acid.

In clinical studies, an increase in the frequency of adverse reactions from the digestive system was observed when using alendronic acid at a dose of more than 10 mg / day during therapy with acetylsalicylic acid.


Side effect

From the digestive system: pain in the epigastric region; rarely - constipation, diarrhea, flatulence, dysphagia.

From the side of metabolism: asymptomatic hypocalcemia.

Dermatological reactions: skin rash, erythema.

Others: headache, myalgia.