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Floxin (Ofloxacin) is used to treat infections caused by microorganisms sensitive to the drug: infections of the respiratory tract, ear, throat, nose, skin, soft tissues, bones, joints, lower and upper urinary tract, infections of the abdominal cavity and small pelvis, prostatitis, uncomplicated gonorrhea, sepsis.

Brand: Ofloxacin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Product description

Pharmacological action of Floxin

Buy Floxin in Canada

Acts on the bacterial enzyme DNA-gyrase, which ensures supercoiling and, thus, the stability of the DNA (deoxyribonucleic acid) of bacteria (destabilization of DNA strands leads to their death). It has a broad spectrum of action and has a bactericidal effect.


Active against microorganisms producing beta-lactamases and fast-growing atypical mycobateria. Susceptible: Staphylococcus aureus, Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter, Klebsiella spp., (Including Klebsiella pneumoniae), Enterobacter spp. (including Enterobacter cloacae), Hafnia, Proteus spp. (including Proteus mirabilis, Proteus vulgaris - indole positive and indole negative), Salmonella spp., Shigella spp. (including Shigella sonnei), Yersinia enterocolitica, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp. (including Chlamydia trachomatis), Legionella spp., Serratia spp., Providencia spp., Haemophilus ducreyi, Bordetella parapertussis, Bordetella pertussis, Moraxella catarrhalis, Propionibacterium acnes, Staphylo Brucella spp.,

Different sensitivities to the drug are possessed by: Enterococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium pylori, Mycobacterium tuberculosis. , Listeria monocytogenes, Gardnerella vaginalis.

In most cases insensitive: Nocardia asteroides, anaerobic bacteria (eg Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacterium spp., Fusobacterium spp., Clostridium difficile). Does not work on Treponema pallidum.


After oral administration, it is rapidly and completely absorbed. Bioavailability - over 96%, binding to plasma proteins - 25%. Tmax is 1-2 hours, Cmax after administration at a dose of 100, 300, 600 mg is 1, 3.4 and 6.9 mg / l. After a single dose of 200 or 400 mg, it is 2.5 μg / ml and 5 μg / ml, respectively.

The apparent volume of distribution is 100 liters. Penetrates into tissues, organs and environments of the body: into cells (leukocytes, alveolar macrophages), skin, soft tissues, bones, abdominal and pelvic organs, respiratory system, urine, saliva, bile, prostate secretion, passes well through the BBB, placental barrier, excreted in breast milk. Penetrates into the cerebrospinal fluid with inflamed and non-inflamed meninges (14-60%).

It is metabolized in the liver (about 5%) with the formation of N-oxide ofloxacin and dimethyl ofloxacin. T1/2 does not depend on the dose and is 4.5-7 hours. Excreted by the kidneys 75-90% (unchanged), about 4% - with bile. Extrarenal clearance is less than 20%.

After a single dose of 200 mg in urine, it is detected within 20-24 hours. In renal / hepatic insufficiency, excretion may slow down. Does not cumulate.

Indications of the drug Floxin

Floxin for the treatment of respiratory tract infections

Respiratory tract infections (bronchitis, pneumonia), ENT organs (sinusitis, pharyngitis, otitis media, laryngitis), skin, soft tissues, bones, joints, infectious and inflammatory diseases of the abdominal cavity and biliary tract (excluding bacterial enteritis) , kidneys (pyelonephritis), urinary tract (cystitis, urethritis), pelvic organs and genitals (endometritis, salpingitis, oophoritis, cervicitis, parametritis, prostatitis, colpitis, orchitis, epididymitis), gonorrhea, chlamydia, septicemia (only for iv / in the introduction), meningitis, prevention of infections in patients with impaired immune status (including neutropenia); bacterial corneal ulcers, conjunctivitis, blepharitis, meibomitis (barley), dacryocystitis, keratitis, chlamydial eye infections.

Method of administration and dosage

Floxin drug label

Inside, before or during meals, whole with water. Doses are selected individually depending on the localization and severity of the infection, as well as the sensitivity of microorganisms, the general condition of the patient and the function of the liver and kidneys.

Adults - 200-800 mg per day, the course of treatment is 7-10 days, the frequency of use is 2 times a day. A dose of up to 400 mg - in 1 dose, preferably in the morning. With gonorrhea - 400 mg once.

In patients with impaired renal function (with Cl creatinine 50–20 ml / min), a single dose should be taken 1 time per day or 50% of the average dose 2 times a day. When Cl creatinine is less than 20 ml / min, a single dose is 200 mg, then 100 mg per day every other day.

With hemodialysis and peritoneal dialysis - 100 mg every 24 hours. The maximum daily dose for liver failure is 400 mg.

The duration of the course of treatment is determined by the sensitivity of the pathogen and the clinical picture; treatment should be continued for at least 3 days after the symptoms of the disease disappear and the temperature is completely normalized. In the treatment of salmonellosis, the course of treatment is 7–8 days, with uncomplicated infections of the lower urinary tract - 3-5 days.

Children - only for health reasons, if it is impossible to replace with other drugs. The average daily dose is 7.5 mg / kg, the maximum is 15 mg / kg.


Deficiency of glucose-6-phosphate dehydrogenase, epilepsy (including history), decrease the seizure threshold (including after traumatic brain injury, stroke, or inflammation of the CNS), age 18 years (till completion of skeletal growth), pregnancy, breastfeeding period. For ointments - children's age - up to 1 year.

With care - atherosclerosis of the cerebral vessels, cerebrovascular accident (in history), chronic renal failure, organic lesions of the central nervous system.

Application during pregnancy and lactation

Contraindicated in pregnancy. During treatment, breastfeeding should be discontinued.


Symptoms: dizziness, confusion, lethargy, disorientation, drowsiness, vomiting.

Treatment: gastric lavage, symptomatic therapy.


The total duration of the course of treatment is not more than 2 months. Should not be exposed to sunlight and UV rays.

In case of development of side effects from the central nervous system, allergic reactions, pseudomembranous colitis, the drug should be discontinued. For pseudomembranous colitis proven colonoscopically and / or histologically, oral administration of vancomycin and metronidazole is indicated.

Rarely occurring tendonitis can rupture tendons (mainly the Achilles tendon), especially in older patients. In case of signs of tendinitis, you must immediately stop treatment, immobilize the Achilles tendon and consult an orthopedist.

In patients with impaired renal or hepatic function, the plasma concentration of ofloxacin should be monitored. In severe renal and hepatic insufficiency, the risk of developing toxic effects increases (dose adjustment is required.)

Special instructions

Not the drug of choice in the treatment of pneumococcal pneumonia, not indicated for the treatment of acute tonsillitis.

During the period of treatment, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions. Do not drink alcohol.

During treatment with the drug, hygienic tampons of the Tampax type should not be used, due to the increased risk of developing thrush.

On the background of treatment, it is possible that the course of myasthenia gravis may worsen, and porphyria attacks increase in predisposed patients.

False negative results are possible in bacteriological diagnosis of tuberculosis (prevents the release of Mycobacterium tuberculosis).

Side effects

From the digestive tract: gastralgia, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, increased activity of hepatic transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis.

From the nervous system and sensory organs: headache, dizziness, lack of confidence in movements, tremors, convulsions, numbness and paresthesias of the extremities, intense dreams, "nightmares", psychotic reactions, anxiety, arousal, phobias, depression, confusion, hallucinations, increased intracranial pressure; violation of color perception, diplopia, disturbance of taste, smell, hearing and balance. When applying the ointment - a burning sensation and discomfort in the eyes, hyperemia, itching and dryness of the conjunctiva, photophobia, lacrimation.

On the part of the musculoskeletal system: tendonitis, myalgia, arthralgia, tendosynovitis, tendon rupture.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): tachycardia, decrease in blood pressure (with intravenous administration; with a sharp decrease in blood pressure, administration is stopped), vasculitis, collapse; leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia.

Allergic reactions: skin rash, itching, urticaria, allergic pneumonitis, allergic nephritis, eosinophilia, fever, Quincke's edema, bronchospasm, Stevens-Johnson and Lyell's syndrome, photosensitivity, erythema multiforme, rarely - anaphylactic shock.

From the side of the skin: punctate hemorrhages (petechiae), bullous hemorrhagic dermatitis, papular rash with a crust, indicating vascular lesions (vasculitis).

From the genitourinary system: acute interstitial nephritis, renal dysfunction, hypercreatininemia, increased urea content.

Others: dysbiosis, superinfection, hypoglycemia (in patients with diabetes mellitus), vaginitis.