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|Feldene 10 mg|
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Pharmacological action of Feldene
A non-steroidal anti-inflammatory drug from the oxicam group. It has anti-inflammatory, analgesic and antipyretic effects.
The mechanism of action is associated with inhibition of prostaglandin synthesis due to inhibition of cyclooxygenase activity.
Relieves pain. Weakens or relieves inflammation and pain in joints at rest and during movement, reduces morning stiffness and swelling of the joints, helps to increase the range of motion.
The analgesic effect occurs 30 minutes after taking the drug inside. The anti-inflammatory effect appears by the end of the first week of treatment. After a single dose, the action continues for 24 hours.
Pharmacokinetics of the drug Feldene
After oral administration, piroxicam is well absorbed from the gastrointestinal tract. Cmax in plasma is achieved within 3-5 hours.
Plasma protein binding is 98%. Vd - 0.12-0.14 l / kg.
Metabolized in the liver by hydrolysis and conjugation.
It is excreted from the body mainly in the urine (2/3 of the dose taken) and in small quantities in the feces. T1/2 is about 36-45 hours.
Indications of the drug Feldene
joint diseases: rheumatoid arthritis, chronic polyarthritis, ankylosing spondylitis, Reiter's syndrome, psoriatic polyarthritis, arthrosis (coxarthrosis, gonarthrosis, spondyloarthrosis and polyarthrosis);
soft tissue diseases: periarthritis, bursitis, tendinitis;
cervicobrachial syndrome, lumbago, sciatica;
pain after surgical, orthopedic, gynecological, dental interventions;
post-traumatic conditions (pain syndrome during sprains, dislocations, fractures);
dysmenorrhea, adnexitis, cystitis.
How to apply: dosage and course of treatment
Inside, intramuscularly, rectally, externally.
Inside. With rheumatoid arthritis, osteoarthritis and ankylosing spondylitis - 10-30 mg / day in 1 dose, for a long time.
In acute diseases of skeletal muscles - 40 mg / day in one or more doses for 2 days, in the next 7-10 days - 20 mg / day.
In the treatment of acute gout, the initial dose is 40 mg, once, in the first 2 days, then for 4-6 days - 40 mg 1 time or 20 mg 2 times a day.
With dysalgomenorrhea, treatment should be started when the first symptoms appear at an initial dose of 40 mg / day in 1 or more doses for 2 days. In the next 1-3 days - 20 mg in 1 dose.
As an antipyretic drug - 10-20 mg / day; if it is necessary to quickly achieve the effect, 40 mg / day is prescribed for the first 2 days, followed by a dose reduction.
In juvenile rheumatoid arthritis, it is prescribed once a day: children weighing less than 15 kg - 5 mg / day, 16-25 kg - 10 mg / day, 26-45 kg - 15 mg / day, more than 46 kg - 20 mg / days
V / m. For the treatment of acute conditions or relief of an exacerbation of a chronic process - 20-40 mg once a day. After stopping the acute stage of the process, they switch to supportive therapy with tablets or capsules.
Rectally, 10-40 mg 1-2 times a day.
Outwardly, a gel or cream is applied to the affected areas (column 5-10 mm) 3-4 times a day; no occlusive dressing is applied.
Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract (in the acute stage), "aspirin" asthma, hepatic and / or renal failure; bleeding disorders (including hemophilia, prolongation of bleeding time, tendency to bleeding, hemorrhagic diathesis); children's age (up to 14 years old), age over 65 years old, pregnancy, lactation period;
for rectal administration - proctitis, anorectal bleeding.
Patients with impaired gastrointestinal function, after extensive surgical interventions, in old age, patients with bronchial asthma and chronic bronchospastic diseases in history, it is necessary to monitor the cellular composition of the blood, kidney and liver function.
In women, a decrease in the contraceptive effect of the IUD is possible due to the effect of piroxicam on the tone of the myometrium.
Recommendations for use in children are currently not developed.
During treatment, you should exclude the use of ethanol.
Should not be applied to damaged skin. Avoid contact with eyes or mucous membranes.
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Displaces drugs from the connection with blood proteins, reduces the effectiveness of antihypertensive drugs (due to the retention of Na +, K + and water in the body), increases the concentration of phenytoin and Li + drugs.
Increases the risk of hyperkalemia when combined with potassium-sparing diuretics and K + donors, the risk of ulceration of the gastrointestinal mucosa - with GCS.
ASA reduces the concentration of piroxicam in serum. In combination with anticoagulants, it reduces the ability of platelets to aggregate (risk of bleeding).
Myelotoxic drugs increase the manifestations of the drug's hematotoxicity.
From the nervous system: dizziness, headache, drowsiness, insomnia, depression, irritability, hallucinations, paresthesias, lethargy, mood changes.
From the urinary system: impaired renal function, interstitial nephritis, papillary necrosis, nephrotic syndrome.
From the digestive system: nausea, decreased appetite, abdominal pain, flatulence, constipation or diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract; liver dysfunction, increased activity of "hepatic" transaminases; dry mouth, stomatitis.
From the side of the hematopoietic system and the hemostasis system: anemia, aplastic anemia, hemolytic anemia, leukopenia, eosinophilia, thrombocytopenia, decreased hematocrit; atrombocytopenic purpura (Shenlein-Henoch disease).
From the CVS: increased blood pressure, decreased blood pressure, rarely - palpitations, shortness of breath.
Others: swelling of the legs and feet, increased sweating, increased concentration of urea; hypoglycemia.
Allergic reactions: skin rash, itching, swelling of the face, larynx, bronchospasm, malignant exudative erythema (Stevens-Johnson syndrome), shock, photosensitivity; vasculitis, serum sickness.
Local reactions: when using suppositories - irritation of the rectal mucosa, burning, tenesmus. With i / m introduction - the formation of aseptic necrosis, necrosis of adipose tissue.