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Estrace used to treat conditions of menopause (eg, hot flashes; vaginal itching, burning, or dryness), treating the vulva or vaginal atrophy, and preventing osteoporosis (brittle bones).

Brand: Estradiol

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
Package Price Per pill Save Order
Estrace 2 mg
280 pills - 2 mg
+ 12 free Viagra 100 mg, 7% discount for future orders
$309.33 $1.10 $219.97 Add to cart
140 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$161.96 $1.16 $102.69 Add to cart
112 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$143.41 $1.28 $68.31 Add to cart
84 pills - 2 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$117.37 $1.40 $41.42 Add to cart
56 pills - 2 mg $85.25 $1.52 $20.61 Add to cart
28 pills - 2 mg $52.93 $1.89 No Add to cart
Estrace 1 mg
280 pills - 1 mg
+ 8 free Viagra 100 mg, 5% discount for future orders
$203.61 $0.73 $155.89 Add to cart
140 pills - 1 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$106.79 $0.76 $72.96 Add to cart
112 pills - 1 mg $95.95 $0.86 $47.85 Add to cart
84 pills - 1 mg $77.81 $0.93 $30.04 Add to cart
56 pills - 1 mg $55.23 $0.99 $16.67 Add to cart
28 pills - 1 mg $35.95 $1.28 No Add to cart

Product description

Pharmacokinetics of Estrace 

Buy Estrace in Canada

After oral administration, it is rapidly and completely absorbed. During the first passage through the liver, it is metabolized to less active products: estrone and estriol. Binds to blood plasma proteins, mainly globulin, which binds sex hormones. It is excreted in the bile into the lumen of the small intestine and is reabsorbed. The final loss of activity occurs as a result of oxidation in the liver. Metabolic products are excreted mainly by the kidneys in the form of sulfates and glucuronides.


Estrace drug label

Causes moderate endometrial proliferation and improves the trophism of the genitourinary system. Estradiol plays an important role in bone metabolism and thus prevents the development of osteoporosis. By acting on the hypothalamic-pituitary system, it eliminates vegetative-vascular and psycho-emotional disorders.

Therapeutic indications of Estrace 

Estrace for menopause treatment

Physiological or postoperative menopause (hot flashes, sleep disorders, urogenital atrophy, mental instability, mood disorders); postmenopausal osteoporosis (prevention).


Breast cancer and other estrogen-dependent tumors (diagnosed or suspected), endometriosis, vaginal bleeding of unknown etiology; severe diseases of the kidneys, liver, cardiovascular system; thromboembolism and thrombophlebitis (including in history), pregnancy, childhood.


Symptoms: nausea, vomiting, in some cases - metrorrhagia.

Treatment: drug withdrawal, symptomatic therapy aimed at maintaining vital functions. There is no specific antidote.


Barbiturates, tranquilizers, narcotic analgesics, anesthetic and some antiepileptic drugs (carbamazepine, phenytoin), inducers of liver microsomal enzymes accelerate the metabolism of estradiol, reduce the effect of the drug.

Plasma concentration decreases with the simultaneous use of phenylbutazone and some antibiotics (ampicillin, rifampicin), which is associated with a change in microflora.

Folic acid and thyroid medications enhance the effects of estradiol.

Estradiol increases the effectiveness of lipid-lowering drugs.

Weakens the effects of male sex hormone drugs, hypoglycemic, diuretic, antihypertensive drugs and anticoagulants.

Reduces glucose tolerance, therefore, dose adjustment of hypoglycemic agents may be required.

Estrace side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Estrace: hives; Labored breathing; Swelling of the face, lips, tongue, or throat.

Call your doctor right away if you have:

  • Heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • Signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

  • Signs of a blood clot in your lungs - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

  • Signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs;

  • Swelling or tenderness in the stomach;

  • Jaundice (yellowing of the skin or eyes);

  • Unusual vaginal bleeding;

  • A lump in the chest;

  • Fluid retention (swelling, rapid weight gain); or

  • high blood calcium levels - nausea, vomiting, stomach pain, loss of appetite, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or anxious.

Common Estrace side effects may include:

  • chest pain;

  • Headache;

  • Vaginal itching or discharge, changes in menstrual periods, easy vaginal bleeding or spotting;

  • Thinning of scalp hair; or

  • Nausea, vomiting, bloating, stomach cramps.