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Differin® can be used to treat acne both in monotherapy and in combination with other local or systemic drugs (antibiotics, oral antiandrogens)

Brand: Adapalene

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Package Price Per pill Save Order
Differin 15 g
20 tubes - 15 g
+ 12 free Viagra 100 mg, 7% discount for future orders
$309.97 $15.50 $236.36 Add to cart
15 tubes - 15 g
+ 8 free Viagra 100 mg, 5% discount for future orders
$251.99 $16.80 $157.76 Add to cart
10 tubes - 15 g
+ 4 free Viagra 100 mg, 3% discount for future orders
$189.93 $18.99 $83.24 Add to cart
5 tubes - 15 g
+ 4 free Viagra 100 mg, 3% discount for future orders
$123.99 $24.80 $12.59 Add to cart
3 tubes - 15 g $81.95 $27.32 No Add to cart

Product description

Pharmacological action of Differin

Buy Differin gel in Canada

Means for external use. Adapalene is a retinoid metabolite, has a comedolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation.

The mechanism of action of adapalene is based on interaction with specific γ-receptors of epidermal skin cells. As a result of the action of adapalene, in particular, there is a decrease in the "cohesion" of epithelial cells at the mouth of the sebaceous hair follicle and a decrease in the prerequisites for the formation of microcomedones.

Adapalene has an anti-inflammatory effect in vitro and in vivo, acting on inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.


Absorption of adapalene through the skin is very low (about 4% of the applied dose). Elimination of adapalene from the body occurs mainly with bile.

Indications of active substances of the drug Differin®

Treating acne with Differin gel

  • Acne.

Dosage regimen of Differin

Differin gel appearance

Apply externally. Apply evenly to the affected surface 1 time / day before bedtime, avoiding contact with the mucous membranes of the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment.

Contraindications to use

Pregnancy; lactation period (breastfeeding); hypersensitivity to adapalene.

Application during pregnancy and lactation

It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

Special instructions

Caution should be used for dermatitis, eczema.

Avoid direct sunlight as skin irritation may occur. Treatment can be continued if sun exposure is minimized.

The simultaneous use of cosmetics with drying and irritating effect on the skin (for example, perfume or ethanol-containing products) is not recommended.

Adapalene applied to the skin in the evening can be combined with acne medications applied in the morning.

Drug Interactions

Since adapalene does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as clindamycin phosphate or benzoyl peroxide.

Side effect

Dermatological reactions: skin irritation (treatment must be suspended until skin irritation disappears or the frequency of use must be reduced).