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|Diclofenac Gel 30 g|
12 tubes - 30 g
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|9 tubes - 30 g||$82.99||$9.22||$33.56||Add to cart|
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The composition of the Diclofenac gel
Gel contains 10 mg of diclofenac diethylamine as an active ingredient (in terms of diclofenac sodium).
Excipients: ethyl alcohol 96%, propylene glycol, macrogol 400, glycerin, dimethyl sulfoxide, carbomer, diethanolamine, purified water.
Non-steroidal anti-inflammatory drugs for external use
Indications for use Diclofenac gel
For local symptomatic treatment of pain and inflammation in:
Traumatic injury to tendons, ligaments, muscles and joints (for example, as a result of dislocation, sprains or bruises).
Localized forms of rheumatic diseases with soft tissue damage.
Dosage and administration
Adults and children over 14 years of age: a small amount of gel 2- (strip of gel 1-) is applied 2-3 times a day with a thin layer on the skin over the inflammation and lightly rubbed until completely absorbed. After applying the gel, wash your hands thoroughly, except for cases when the drug must be applied directly to your hands. The interval between application of the drug should be at least 4 hours.
If symptoms persist for 7 days or if the condition worsens, a doctor should be consulted.
Do not use for more than 7 days unless otherwise advised by your doctor.
Elderly: The usual dose may be used.
Children and adolescents: there is insufficient data on efficacy and safety for children and adolescents under 14 years of age (see section Contraindications). When using the drug in children 14 years of age and older for more than 7 days, as well as if the condition worsens, parents should consult a doctor.
Due to the low systemic absorption, the development of an overdose with topical application is unlikely. However, the development of undesirable effects similar to the effects of an overdose of oral forms of diclofenac in case of accidental or deliberate swallowing of the gel is possible.
In case of ingestion, it is possible to develop pronounced systemic side effects that require conventional therapeutic measures in the treatment of NSAID poisoning, including gastric lavage and the intake of adsorbents (activated carbon) as soon as possible after ingestion.
In case of overdose, pathogenetic and symptomatic therapy is used. The typical clinical picture with an overdose of diclofenac is absent. Specific therapy (for example, forced diuresis, dialysis, hemoperfusion) is ineffective due to the high binding of NSAIDs to proteins and their intensive metabolism.
Patients with asthma attacks, urticaria or acute rhinitis arising from the use of acetylsalicylic acid (aspirin) or other non-steroidal anti-inflammatory drugs (NSAIDs).
Hypersensitivity to diclofenac, acetylsalicylic acid, NSAIDs or any of the excipients.
Third trimester of pregnancy.
Simultaneous oral administration with other NSAIDs.
Diclofenac, gel is contraindicated when used simultaneously with other drugs containing diclofenac.
Application in children and adolescents under the age of 14 years.
The drug should be applied only to intact skin areas, avoiding contact with open wounds.
Avoid contact of the gel with eyes and mucous membranes.
When the drug is applied to large areas of the skin and / or with its prolonged use, the possibility of manifestation of systemic side effects of diclofenac cannot be completely excluded.
During therapy with this drug, it is possible to increase the activity of liver enzymes.
If you experience any side effects, you must stop using the gel and consult a doctor.
You should consult your doctor before using the gel when taking other nonsteroidal anti-inflammatory drugs.
In isolated cases, gastrointestinal bleeding was reported in patients with an active phase or a history of gastric or duodenal ulcers.
Diclofenac, like other NSAIDs that inhibit the activity of prostaglandin synthetase, can provoke the development of bronchospasm in patients with asthma or a history of allergic diseases.
It is necessary to stop using the drug if a skin rash occurs. Diclofenac Gel contains propylene glycol, which may cause localized skin irritation in some people.
Diclofenac gel cannot be used under an occlusive dressing.
Interaction with other medicinal products
Interaction with other medicinal products is unlikely due to the low systemic absorption of diclofenac when applied topically. The interaction of Diclofenac gel with other drugs has not been registered, but when prescribing drugs at the same time, it is necessary to take into account the information contained in the instructions for medical use for the oral form of diclofenac.
Concurrent use of Diclofenac, gel with aspirin or other NSAIDs may increase the risk of adverse reactions.
Use during pregnancy and lactation
Use during pregnancy
Plasma concentration of diclofenac after topical application is lower than after oral administration. Given the information obtained with the systemic use of NSAIDs, the following is recommended:
Inhibition of prostaglandin synthesis can adversely affect the course of pregnancy and / or the embryo / fetus. Epidemiological data show an increased risk of miscarriage and the formation of heart disease and gastroschisis when using inhibitors of prostaglandin synthesis in early pregnancy. The risk of developing heart disease increases from less than 1% to about 1.5%. The increased risk is thought to occur with increasing dose and duration of treatment. In animal experiments, the administration of an inhibitor of prostaglandin synthesis leads to an increase in the risk of pre- and post-implantation miscarriage and fetal mortality. In addition, there is an increase in the incidence of various malformations, including the cardiovascular system, in animals treated with inhibitors of prostaglandin synthesis during organogenesis.
Prescribing diclofenac is not recommended in the first and second trimester of pregnancy, except in cases where the benefits of using the drug outweigh the risk of using it. If diclofenac is used during pregnancy planning, first or second trimesters of pregnancy, the drug is prescribed in the lowest dose for the shortest period of time.
- The use of inhibitors of prostaglandin synthesis in the third trimester of pregnancy can lead to the development of: heart defects (premature closure of the ductus arteriosus with the development of pulmonary hypertension);
- impaired renal function, up to the development of renal failure with oligohydroamnion;
When using the drug at the end of pregnancy in the mother and / or newborn, the following effects may appear:
prolongation of bleeding time, antiplatelet effect, which can develop even when very low doses are taken.
decreased contractility of the uterus, which can cause delayed or prolonged labor.
Therefore, diclofenac is contraindicated during the third trimester of pregnancy.
Application during breastfeeding
Like other NSAIDs, diclofenac passes into breast milk in small amounts. However, no effect on a breastfed baby is expected when using Diclofenac, gel in therapeutic doses. Due to the lack of controlled studies in women during breastfeeding, the drug should be used only under medical supervision. Diclofenac, the gel should not be applied to the chest area, as well as to large areas of the skin and / or for a long period of time.
Influence on the ability to drive and work with mechanisms
When Diclofenac is applied topically, the gel does not affect the ability to drive and work with mechanisms.
Frequency of side effects: very common (≥1 / 10); often (≥1 / 100 to <1/10); infrequently (≥1 / 1000 to <1/100); rarely (≥1 / 10000 to <1/1000); very rare (<1/10000); not known: frequency of occurrence cannot be estimated from the available data.
From the immune system: very rarely - hypersensitivity reactions (including urticaria), angioedema.
Infections and invasions: very rarely - pustular rash.
From the respiratory system and chest organs: very rarely - asthma.
On the part of the skin and subcutaneous fat: often - rash, eczema, erythrema, dermatitis (including contact dermatitis), itching; rarely, bullous dermatitis; very rarely - photosensitivity.
The concentration of diclofenac in plasma after the use of Diclofenac gel is lower than when taking oral forms of diclofenac, and, accordingly, the likelihood of systemic side effects when applied topically is significantly lower compared to the frequency of side effects against the background of oral administration of the drug. However, when Diclofenac gel is applied to a relatively large surface of the skin for a long period of time, the likelihood of systemic side effects cannot be completely excluded. If it is necessary to use the drug on a large surface area of the body for a long time, it is necessary to take into account the possibility of the development of side effects indicated in the instructions for medical use of oral dosage forms of diclofenac.