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Desyrel Trazodone relieves mental (affective tension, fear, insomnia) and somatic (palpitations, headache, myalgia, increased urination, increased sweating) manifestations of anxiety. Trazodone increases the depth and duration of sleep in depressed patients, restores the physiological structure of sleep.

Brand: Trazodone

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Desyrel 100 mg
360 pills - 100 mg
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90 pills - 100 mg $84.97 $0.94 $35.00 Add to cart
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30 pills - 100 mg $39.99 $1.33 No Add to cart
Desyrel 50 mg
360 pills - 50 mg
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60 pills - 50 mg $59.59 $0.99 $14.51 Add to cart
30 pills - 50 mg $37.05 $1.24 No Add to cart
Desyrel 25 mg
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Product description

Pharmacology of Desyrel

Buy Desirel in Canada

Pharmacological action - antidepressant.

The mechanism of action is not fully understood. Preclinical studies have shown that trazodone selectively inhibits the reuptake of serotonin by synaptosomes in the brain and acts as an antagonist of 5-HT2A / 2C serotonin receptors. Does not inhibit MAO, does not stimulate the central nervous system. It is an antagonist of the alpha1adrenoceptor.

It relieves mental (affective tension, fear, insomnia) and somatic (palpitations, headache, myalgia, frequent urination, increased sweating) manifestations of anxiety. Increases the depth and duration of sleep in depressed patients, restores the physiological structure of sleep.

It is well absorbed from the digestive tract. Taking trazodone during or immediately after a meal slows down the rate of absorption, decreases the Cmax of trazodone in the blood and increases the Tmax (Tmax is 0.5–2 hours). Plasma protein binding 89–95%. Passes through histohematogenous barriers, including the BBB. It is metabolized in the liver, mainly with the participation of the isoenzyme CYP3A4 of cytochrome P450, the active metabolite is m-chlorophenylpiperazine. T1/2 is- twophase: the duration of the early phase is 3–6 hours, the late 5–9 hours; in some patients, cumulation is possible. It is excreted in the bile (20%) and in the urine (75%, including 70% in the form of inactive metabolites) within 98 hours after administration.

There is evidence of the effectiveness of trazodone in bulimia, kleptomania, pain syndrome in diabetic neuropathy and other types of chronic pain, phobias, incl. agoraphobia, panic attacks, acute withdrawal symptoms in alcoholism and for the prevention of migraine.

Application of the substance Trazodone

Using Desyrel during depression

Depressive states of various etiologies (endogenous, psychotic, neurotic, somatogenic, etc.) with severe anxiety, tension.

Dosing of the drug Desyrel

Inside. The initial dose for adults is 150 mg / day in 2 divided doses: 2/3 of the total daily dose is taken before bedtime (to avoid drowsiness, dizziness), and the rest - in the morning or during the day, in divided doses.

If necessary, the daily dose is increased by 50 mg / day, at intervals of 3-4 days, until the optimal effect is achieved.

The maximum daily dose for outpatients is 450 mg, for inpatients - 600 mg.

The initial daily dose for elderly and debilitated patients is 75 mg, if necessary, it can be gradually increased at intervals of 3-4 days, but not more than up to 300 mg.

In mild forms of depression, the average maintenance dose is 150 mg / day, in moderate and severe forms - 300 mg / day.

The initial dose for children 6-18 years old is 1.5-2 mg / kg / day in divided doses, if necessary, the dose is gradually increased to 6 mg / kg / day. In case of violation of libido, the daily dose is 50 mg; in the treatment of impotence in the case of monotherapy - 200 mg / day, in the complex therapy - 50 mg. In the treatment of benzodiazepine drug dependence, the recommended regimen is based on a gradual reduction in the benzodiazepine dose. Each time the dose is reduced by 1/4 or 1/2 of the tablet, 50 mg of trazodone is added at the same time. This ratio remains unchanged for 3 weeks, then continue to reduce the dose of benzodiazepine until it is completely canceled. After that, they move on to reducing the daily dose by 50 mg every 3 weeks.

Children 6-18 years old: an initial dose of 1.5-2 mg / kg / day, divided into several doses. If necessary (taking into account tolerance), the dose is gradually increased to 6 mg / kg / day with an interval of 3-4 days.


Hypersensitivity, alcohol intoxication and intoxication with hypnotic drugs, age up to 6 years.

Restrictions on the use of

myocardial infarction (early recovery period), AV blockade, arterial hypertension (correction of doses of antihypertensive drugs may be required), ventricular arrhythmia, a history of priapism, hepatic and / or renal failure, age up to 18 years.

Application during pregnancy and lactation

Do not use in pregnant women. In animal experiments, it was shown that trazodone at doses 30-50 times higher than the MRDC, causes congenital malformations and increases the frequency of fetal resorption.

FDA category of action on the fetus is C.

Breastfeeding should be discontinued during treatment. Trazodone and its metabolites are found in the milk of lactating rats. It is not known whether trazodone is secreted into human breast milk.


Unlike typical antidepressants, it does not reduce the depressing effects of reserpine, weakens the central effect of amphetamine and the peripheral effect of norepinephrine. It potentiates the effect of drugs that depress the central nervous system (including barbiturates, tricyclic antidepressants, antihistamines, clonidine, alcohol), anticholinergics and muscle relaxants. When taken simultaneously with antihypertensive drugs, the risk of orthostatic hypotension increases. Weakens the effect of psychostimulants. Increases the plasma concentration of digoxin and phenytoin. Do not use concomitantly with MAO inhibitors.


Symptoms: nausea, vomiting, drowsiness, dizziness, low blood pressure, impaired coordination, priapism, epileptiform seizures, ECG changes, respiratory arrest, aggravation of adverse reactions.

Treatment: gastric lavage, forced diuresis, intake of activated charcoal, maintenance of vital functions, symptomatic therapy. There is no specific antidote.

Precautions of the substance Trazodone

During treatment, a complete blood count should be performed regularly (for the timely detection of leuko- and neutropenia), ECG monitoring in patients with cardiovascular diseases is desirable. Careful monitoring of patients with suicidal tendencies is required, especially in the first weeks of treatment. Treatment is stopped immediately with the development of priapism, severe neutro- and leukopenia; in other cases, drug withdrawal should be carried out gradually. Alcohol intake should be avoided during treatment.

Use with caution during work for drivers of vehicles and people whose activities are associated with increased concentration of attention.

Side effects of the substance Trazodone

From the nervous system and sensory organs: fatigue, weakness, headache, dizziness, insomnia, drowsiness, agitation, psychosis, hypomania, hallucinations, tremors, muscle twitching, large seizures (grand mal), aphasia, ataxia, akathisia, dyskinesia, paresthesia, confusion, syncope, blurred vision, diplopia.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): arterial hypotension, incl. orthostatic; atrial fibrillation, arrhythmias (including tachy- and bradycardia, ectopic ventricular rhythms), congestive heart failure, leukocytosis or leukopenia, neutropenia (usually minor), hemolytic anemia, methemoglobinemia.

From the digestive tract: increased appetite, dryness and an unpleasant taste in the mouth, hypersalivation, caries, diseases of the periodontal tissues, oral candidiasis, nausea, vomiting, flatulence, diarrhea, constipation, cholestasis, increased levels of bilirubin and amylase in the blood plasma, jaundice.

From the genitourinary system: urinary retention, increased urination, hematuria, premature menstruation, hirsutism, increased libido, priapism, impotence, retrograde ejaculation.

Allergic reactions: skin rash, urticaria.

Others: myalgia, chest pain, alopecia, psoriasis, edema.