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Colchicine

Colchicine
Colchicine drug is able to significantly inhibit cell division, stops miosis, stops degranulation processes in neutrophils. Colchicine stops the development of amyloidosis, reduces the rate of formation of amyloid fibrils. Colchicine tablets are highly effective in relieving and preventing acute gout attacks. The therapeutic effect develops during the first day of use.

Brand: Colchicine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: September 2023
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Colchicine 0.5 mg
360 pills - 0.5 mg
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$185.91 $0.52 $107.79 Add to cart
270 pills - 0.5 mg
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$145.99 $0.54 $74.29 Add to cart
180 pills - 0.5 mg
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$103.93 $0.58 $42.92 Add to cart
120 pills - 0.5 mg $75.99 $0.63 $21.91 Add to cart
90 pills - 0.5 mg $63.99 $0.71 $9.44 Add to cart
60 pills - 0.5 mg $48.95 $0.82 No Add to cart

Product description

Description of the drug Colchicine

Buy Colchicine in Canada

The drug Colchicine (Colchicine Opocalcium) belongs to the group of anti-gout agents. The active substance has a vegetable base, but it is an alkaloid, therefore, when taking it, it is important to strictly observe the dosage. Colchicine is produced in Germany, Italy, Portugal and India. The price of the drug depends on the manufacturer.

Composition

The active ingredient of the drug Colchicine is Colchicine of the same name. It is an alkaloid that is obtained from the tubers of the splendid colchicum (the plant is also called meadow saffron). It is a fine-crystalline powder of white or white with a yellowish sheen.

 

Excipients:

  • castor oil;

  • lactose monohydrate;

  • starch;

  • aerosil.

The acid-resistant coating of the tablets dissolves in the intestine and prevents absorption of the main active ingredient in the stomach.

Release form

Colchicine packaging

The drug is available in the form of small white tablets, each containing 0.5 or 1 mg of the active ingredient.

The tablets are packed in sealed blisters and packed in a cardboard box.

The number of tablets in a package is 60 pieces.

Pharmacological action of Colchicine

The drug has the following effects: 

  • inhibition of the production of uric acid and slowing down its crystallization;

  • slowing down the movement of leukocytes to the focus of the inflammatory process;

  • reduction of the number of enzymes that take part in chemical reactions in the area of ​​inflammation;

  • suppression of cell division in the focus of inflammation.

The drug also has an analgesic effect.

The tablets stop an acute gouty attack and improve the patient's well-being in the chronic course of the disease.

Pharmacodynamics

Colchicine - an alkaloid of plant origin - provides a therapeutic effect as follows:

  • prevents the movement of neutrophils (a type of leukocytes) to the focus of the inflammatory process;

  • violates the ability of white blood cells to stick together with the vascular endothelium;

  • inhibits the release of interleukins, reduces the production of immunoglobulins, inhibits cellular immune responses.

The effects are dose-dependent. The overall anti-inflammatory effect of taking colchicine is lower than that of non-steroidal anti-inflammatory drugs.

Indications for use Colchicine

Indications for the use of Colchicine

Colchicine is used to treat gout and gouty arthritis. Its effectiveness has also been proven in the treatment of:

  • phlebitis;

  • pseudogout, or chondrocalcinosis;

  • Behcet's disease;

  • scleroderma;

  • inflammatory processes in ENT and dental practice.

In some cases, colchicine tablets are prescribed to patients with amyloidosis, primary biliary cirrhosis, progressive systemic sclerosis.

Interaction

Enhances the effect of deprimating and sympathomimetic drugs. Violates the absorption of vitamin B12. NSAIDs and other drugs that cause myelodepression increase the risk of leukopenia and thrombocytopenia. Anti-gouty activity is reduced by cytostatics (they increase the concentration of uric acid).

Overdose

Symptoms: nausea, vomiting, severe diarrhea, pain in the abdomen and in the mouth, hemorrhagic gastroenteritis, burning skin, severe dehydration with hypotension and hypovolemic shock, decreased myocardial contractility and ST segment elevation on ECG, hematuria, oliguria, convulsions, ascending paralysis , respiratory depression. Possible development of hepatocellular damage, acute renal failure, pulmonary infiltrates. 5 days after an overdose, severe bone marrow suppression with leukopenia, thrombocytopenia, coagulopathy may occur.

Treatment: carried out in a toxicological center. There is no specific antidote. Hemodialysis is ineffective. It is necessary to control the patency of the airways, auxiliary ventilation, monitoring and maintenance of vital functions, normalization of the blood gas composition, electrolyte balance, and anti-shock measures.

Routes of administration

Inside.

Precautions for the substance Colchicine

In case of severe side effects from the gastrointestinal tract, the dose should be reduced or the drug should be discontinued. When the level of leukocytes is below 3 · 109/ l and platelets below 100 · 109/ l, the intake is stopped until the blood picture is restored. Treatment must be carried out under close clinical and hematological control, periodically examine feces for occult blood.

Special instructions

False positive reactions of urine to hemoglobin and erythrocytes are possible.

Side effects of the substance Colchicine

Dyspeptic phenomena (nausea, vomiting, anorexia, diarrhea, etc.) arising from ingestion of high doses, myelosuppression (leukopenia, agranulocytosis, aplastic anemia, thrombocytopenia - usually with long-term treatment), temporary alopecia, liver failure , an increase in the level of alkaline phosphatase and gamma-glutamyl transpeptidase, impaired renal function, depression, myopathy, peripheral neuritis, reversible aspermia, malabsorption syndrome, manifested, in particular, by vitamin Bdeficiency12, skin allergic reactions, local irritation with intravenous administration and extravasation - sharp pain, necrosis.