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Clarinex

Clarinex
Clarinex is indicated for the treatment of allergic asthma, inflammation, allergic rhinitis and other conditions.

Brand: Desloratadine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: November 2023
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Clarinex 5 mg
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Product description

Pharmacological action of Clarinex

Buy Clarinex in Canada

Blocker of histamine H1-receptors (long-acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antipruritic and antiexudative effect. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. It practically does not have a sedative effect and, when taken in a dose of 7.5 mg, does not affect the speed of psychomotor reactions. In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine).

Pharmacokinetics

Clarinex drug appearance

After oral administration, it begins to be determined in plasma after 30 minutes. Food has no effect on distribution. Bioavailability is dose proportional, ranging from 5 mg to 20 mg. Plasma protein binding is 83-87%. After a single dose of 5 mg or 7.5 mg, Cmax is achieved after 2-6 hours (on average, after 3 hours). Does not penetrate the BBB. It is extensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide, only a small part of the dose taken orally is excreted by the kidneys (<2%) and with feces (<7%). T1/2 - 20-30 hours (on average - 27 hours). When using desloratadine at a dose of 5 mg to 20 mg 1 time / day for 14 days, there were no signs of clinically significant cumulation.

Indications of the active substances of the drug Desloratadine

Allergy treatment with Clarinex

Seasonal allergic rhinitis, chronic idiopathic urticaria.

Dosage regimen of Clarinex

Adults and adolescents aged 12 years and older are prescribed orally, regardless of food intake, at a dose of 5 mg / day.

Children aged 1 to 5 years - 1.25 mg 1 time / day, aged 6 to 11 years - 2.5 mg 1 time / day.

Contraindications to the use

Phenylketonuria, pregnancy, lactation, children under 1 year of age, hypersensitivity to desloratadine.

Use during pregnancy and lactation

Desloratadine is contraindicated in pregnancy and lactation (breastfeeding).

Application for impaired renal function

Desloratadine is prescribed with caution in severe renal failure.

Use in children

Contraindicated in children under 2 years of age.

Special instructions

Desloratadine is prescribed with caution in severe renal failure.

Effects on the ability to drive vehicles and use mechanisms

No adverse effects on driving or complex technical devices were observed.

Drug interaction

Study of interaction with ketoconazole and erythromycin revealed no clinically significant changes.

Does not affect the effects of ethanol.

Side effects

In children 12–17 years old, according to the results of clinical studies, the most common side effect is headache (5.9%), the frequency of which was no higher than with placebo (6.9%).

Information on side effects is presented based on the results of clinical studies and post-marketing observations.

According to the WHO, side effects are classified according to their frequency of development as follows: very common (≥1 / 10); often (≥1 / 100 to <1/10); infrequently (from ≥1 / 1000 to <1/100); rarely (from ≥1 / 10000 to <1/1000); very rare (<1/10000); the frequency is unknown (according to the available data, it was not possible to establish the frequency of occurrence).

From the side of the psyche: very rarely - hallucinations.

From the nervous system: often - headache, insomnia (children under 2 years of age); very rarely - dizziness, drowsiness, insomnia, psychomotor hyperactivity, convulsions.

From the liver and biliary tract: very rarely - increased activity of liver enzymes, increased concentration of bilirubin, hepatitis; frequency unknown - jaundice.

From the digestive system: often - dry mouth, diarrhea (children under 2 years of age); very rarely - abdominal pain, nausea, vomiting, dyspepsia, diarrhea.

From the CCC: very rarely - tachycardia, palpitations; frequency unknown - prolongation of the QT interval.

On the part of the musculoskeletal system: very rarely - myalgia.

On the part of the skin and subcutaneous tissues: frequency unknown - photosensitization.

General disorders: often - increased fatigue, fever (children under 2 years of age); very rarely - anaphylaxis, angioedema, shortness of breath, itching, rash, incl. hives; frequency unknown - asthenia.

Post-registration period. Children: frequency unknown - prolongation of the QT interval, arrhythmia, bradycardia.

If any of the side effects indicated in the description are aggravated, or the patient has noticed any other side effects not listed in the description, you should inform your doctor.

Film-coated tablets

The most common side effects (≥1 / 100 to <1/10), the frequency of which was slightly higher than with placebo ("dummies"): increased fatigue (1.2%), dry mouth (0.8%) and headache (0.6%).

Syrup

In children from 6 to 23 months, the following side effects were observed, the frequency of which was slightly higher than with placebo: diarrhea (3.7%), fever (2.3%), insomnia (2.3%).

In children from 2 to 11 years old, when using Erius® syrup, the incidence of side effects was the same as when using placebo.

According to the results of clinical studies, in children from 6 to 11 years old, when taking the drug in the recommended doses (2.5 mg / day), no side effects were revealed.

In adults and adolescents (12 years of age and older), according to the results of clinical studies, side effects were recorded in 3% of patients compared with the group of patients who used placebo, of which the following were most often observed: increased fatigue (1.2%), dryness during mouth (0.8%), headache (0.6%).

In children 12–17 years old, according to the results of clinical studies, the most common side effect is headache (5.9%), the frequency of which was no higher than when taking placebo (6.9%).