What is Ceftin?

Ceftin (cefuroxime) is a cephalosporin (SEF - low spor in) antibiotic. It works by fighting bacteria in your body.

Ceftin is used to treat many types of bacterial infections, including severe or life-threatening forms.

Ceftin may also be used for purposes not listed in this medication guide.

Pharmacokinetics

Cmax after i / m administration - after 30–45 minutes. T1/2 - 70 min. After 24 hours, it is completely excreted in the urine unchanged (most of it - in the first 6 hours): 50% is secreted in the renal tubules, about 50% is filtered in the glomeruli. With inflammation of the meninges, it penetrates the BBB. In bone tissue, synovial fluid and chamber moisture, concentrations are created that exceed the MIC for most microorganisms.

Method of administration and doses

V / m, / in.

Adults - 750 mg 3 times a day i / m or i / v, for severe infections - 1.5 g 3 times a day i / v (if necessary, you can enter every 6 hours, maximum - up to 3-6 g / day) ... For some infections, the appointment of Zinacef at a dose of 750 mg or 1.5 g 2 times a day (i / m or i / v) is effective, followed by oral administration.

Children - 30-100 mg / kg / day in 3-4 doses (for most infections, the optimal dose is 60 mg / kg / day). For newborns - 30-100 mg / kg / day in 2-3 doses.

Gonorrhea: 1.5 g once / m (2 injections of 750 mg in both buttocks).

Meningitis: For the treatment of bacterial meningitis caused by susceptible microorganisms, Zinacef can be used as monotherapy. Adults - 3 g IV every 8 hours; children - 150-250 mg / kg / day IV in 3-4 doses; newborns - 100 mg / kg / day IV.

Prevention of postoperative complications: during operations on the abdominal cavity, pelvis and orthopedic organs, Zinacef in a dose of 1.5 g is injected intravenously during induction of anesthesia. In 8 and 16 hours after the operation, 750 mg intramuscularly can be additionally administered. During operations on the heart, lungs, blood vessels, esophagus during induction of anesthesia, intravenous injection is administered at a dose of 1.5 g, then 750 mg intramuscularly 3 times a day for 24-48 hours. With a complete joint replacement, 1.5 g of cefuroxime powder can be mixed with the polymer bag with methyl methacrylate cement before adding the liquid polymer.

Step therapy

Pneumonia: 1.5 g Zinacef 2–3 times a day (IV or IM) for 48–72 hours, followed by the appointment of Zinnat at a dose of 500 mg 2 times a day for 7–10 days.

Exacerbation of chronic bronchitis: 750 mg of Zinacef 2–3 times a day (IV or IM) for 48–72 hours, followed by the appointment of Zinnat 500 mg 2 times a day for 5–10 days.

The duration of each period (parenteral therapy and oral administration) is determined by the severity of the infection and the general condition of the patient.

Renal failure: cefuroxime is excreted by the kidneys, with renal failure, a decrease in the dose of Zinacef is recommended (see table). However, there is no need to reduce the standard dose of the drug (750 mg - 1.5 g 3 times a day) if the value of Cl creatinine is> 20 ml / min.

Overdose

Symptoms: increased excitability of the brain with the development of seizures.

Treatment: symptomatic. Serum cefuroxime concentrations are decreased with hemodialysis and peritoneal dialysis.

Precautions

Before taking this drug, tell your doctor about any medications you are using, food supplements (such as vitamins, natural supplements, etc.), allergic reactions, existing medical conditions, and current health conditions (such as pregnancy, impending surgery, etc.). The side effects of the drug may be more pronounced depending on the condition of your body. Take this medicine as directed by your doctor or follow the directions for use that came with the medicine. The dosage of the drug depends on your condition. Tell your doctor if your condition has not changed or worsened. Important points to discuss with your healthcare provider are listed below.

• Alcohol consumption
• While taking birth control pills

If you take other drugs or supplements at the same time as this drug, the effectiveness of Ceftin Tablet may change. Tell your healthcare provider about all drugs, vitamins, and supplements you use. Your doctor will be able to make the right dosing plan to avoid negative interactions. Ceftin Tablet may interact with the following drugs and products:

• Aluminum hydroxide
• Calcium carbonate
• Cimetidine
• Famotidine
• Lansoprazole
• Magnesium hydroxide
• Omeprazole
• Oral contraceptives
• Pantoprazole
• Ranitidine

Hypersensitivity to Ceftin Tablet is a contraindication. In addition, Ceftin Tablet should not be used if you have the following conditions:

• Breastfeeding
• Planning a pregnancy
• Pregnancy

Ceftin side effects

Get emergency medical help if you have signs of an allergic reaction to Ceftin: hives; labored breathing; Swelling of the face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody;

• Jaundice (yellowing of the skin or eyes);

• Skin rash, bruising, severe tingling, or numbness;

• Seizure (blackout or seizures);

• Kidney problems - little or no urination, painful or difficult urination, swelling in the legs or ankles, feeling tired or short of breath; or a

• severe skin reaction - fever, sore throat, swelling in your face or tongue, burning eyes, skin pain accompanied by a red or purple skin rash that spreads (especially on the face or upper body) and causes blistering and peeling.

Common Ceftin side effects may include:

• diarrhea;

• Nausea, vomiting;

• Unusual or unpleasant taste in your mouth; or A

• diaper rash in an infant taking Ceftin Liquid.

This is not a complete list of side effects and others may arise. Ask your doctor about side effects.